专利号:US-11225655-B2 优先权日:2010-04-16 标题:Bi-functional complexes and methods for making and using such complexes 发明人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK 权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS 摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
专利号:US-8207337-B2 优先权日:2007-01-29 标 题:Reagent for organic synthesis reaction containing organic triol borate salt 发明人:MIYAURA NORIO; YAMAMOTO YASUNORI 权利人:MIYAURA NORIO; YAMAMOTO YASUNORI; WAKO PURE CHEM IND LTD 摘要:[Problem] n To provide an organoboron compound-containing reagent for organic synthesis reactions which undergoes no trimerization with dehydration, does not necessitate activation with a base, and is stable and highly active. n [Means for Solving Problems] n The reagent for organic synthesis reactions contains an organic triol borate salt represented by any of the general formulae (I) to (III) and general formula (XVI): (wherein R 1 represents alkyl, alkenyl, etc.; R 2 represents optionally substituted alkyl, alkenyl, alkynyl, etc. or represents hydrogen; m + represents an alkaline metal ion, phosphonium ion, or given ammonium ion; M 2+ represents an alkaline earth metal; X represents halogen or alkoxide; Y represents an alkali metal ion, etc.; A represents optionally substituted methylene; and n represents an integer).
专利号:WO-2025006693-A1 优先权日:2023-06-30 标 题 :Cannabidiol-like compounds and methods for the selective preparation of the same 发明人:CHITTIBOYINA AMAR G; CHATTERJEE SHAMBA; PANDEY PANKAJ; KHAN IKHLAS A 权利人:UNIV MISSISSIPPI 摘要:In one aspect, the disclosure relates to new cannabidiol (CBD) analogs produced from allylic monoterpene alcohols and substituted resorcinols in the presence of aryl boronic acids, efficient and mild synthetic methods of making the new CBD analogs, and improved methods of making known CBD analogs. In one aspect, the methods produce low amounts of tetrahydrocannabinol (THC)-like compounds, low amounts of abnormal cannabidiol (abn-CBD) analogs, and higher amounts of CBD analogs, greatly simplifying purification. The methods can be tailored further to produce low amounts of CBD analogs and higher amounts abn-CBD analogs. In the disclosed methods, synthesis parameters can be varied in order to selectively produce a desired normal or abnormal regioisomer.
专利号:EP-2107067-A1 优先权日:2008-04-03 标 题 :Boron catalysed peptide synthesis 发明人:QUAEDFLIEG PETER JAN LEONARD MARIO; NUIJENS TIMO; VRIES DE JOHANNES GERARDUS; KALKEREN VAN HENRI ANTONIUS 权利人:DSM IP ASSETS BV 摘要:The invention relates to a method of synthesising a dipeptide, an oligopeptide or polypeptide comprising coupling a first amino acid or peptide to a second amino acid or peptide in the presence of a boron compound comprising a boron oxygen bond, which boron compound catalyses the formation of a peptidic bond, wherein one of the stereoisomers is formed in excess of the other stereoisomer or stereoisomers.
专利号:KR-20120082477-A 优先权日:2003-12-16 标题:Synthesis Method for Reduction Alkylation of Indole at C-3 Position
摘要:Weibel, J.-M.; Blanc, A.; Pale, P., Science of Synthesis Knowledge Updates, (2018) 1, 61. 摘要:Hall, D. G.; Zheng, H., Science of Synthesis Knowledge Updates, (2011) 4, 90. 摘要:Hay, M. B.; Hicks, J. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 129. 摘要:Lloyd, C. M.; Dowell, K. F.; Brittain, W. D. G., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2.