CAS: 1585-07-5; 1-Bromo-4-Ethylbenzene

相似化合物

2725-82-8 588-93-2 59785-43-2

上下游产品

ethyl bromide bromobenzene diethyl sulfate (4-bromophenyl)magnesium bromide (4-ethylphenyl)trimethylsilane 3-ethylphenol 4-Bromobenzoic acid 1-bromo-4-(1,2-dibromoethyl)benzene

乙基苯 反应生成对溴乙基苯
参考文献:自由基反应中的极性影响.第七部分 原子溴从核取代的二苯甲烷,脱氧苯偶姻和烯丙基苯中提取氢
标题:自由基反应中的极性影响.第七部分 原子溴从核取代的二苯甲烷,脱氧苯偶姻和烯丙基苯中提取氢
摘要:核取代的二苯基甲烷的相对反应性,Deoxybenzoins(x.c 6 H ^ 4 .ch 2 Bz)°已经通过竞争反应的手段通过使用烯丙基苯的确定,并在80朝原子溴allylbenzenes,二苯基甲基醚,和p-溴乙基苯分别作为参考标准.结果表明,通过哈米特方程,三个系统的ρ值分别为-0.93,-0.92和-0.68,前两个系统的σ-常数相关性更好,而在第三个系统中σ +-常数与先前的报告具有更好的相关性.与σ相关的可能原因-常量将被讨论.这些系统的ρ值与先前观测到的反应性值具有一致的反比关系.
Doi:10.1039/j29700000535

专利信息

专利号:US-6355826-B1
优先权日:1997-09-17
标题:Synthesis of stable nitrile oxide compounds
发明人：PARKER DANE KENTON
权利人:GOODYEAR TIRE & RUBBER
摘要:This invention discloses a process for the synthesis of stable aryl nitrile oxides which comprises the sequential steps of (1) halomethylating a halomethyl group onto a substituted aromatic compounds wherein said halomethyl group is halomethylated onto a position that is ortho to at least one of the substituent groups on the substituted aromatic compound; (2) converting the ortho halomethylated-substituted aromatic compound into an ortho-substituted aromatic aldehyde by reacting the ortho halomethylated-substituted aromatic compound with a salt selected from the group consisting of sodium 2-nitropropane and potassium 2-nitropropane in a lower alcohol solvent; (3) converting the ortho-substituted aromatic aldehyde into an ortho-substituted aromatic; and (4) converting the ortho-substituted aromatic oxime into the ortho-substituted aryl nitrile oxide by reacting the ortho-substituted aromatic oxime with an aqueous sodium hypochlorite solution.

专利号:WO-2017082924-A1
优先权日:2015-11-13
标题 :Peptide and peptide mimetic binding antagonists of polo-like kinase 1 polo box domain and methods of use
发明人：BURKE TERRENCE R JR; HYMEL DAVID
权利人:THE US SECRETARY DEPT OF HEALTH & HUMAN SERVICES
摘要:The description provides novel compounds that may serve as anticancer therapeutics. The compounds of the description bind to polo-like kinases through the polo-box domain. The peptide derivatives of the description have achieved improved efficacy in biochemical assays against Plk1. The description also provides methods of use, methods of preparation, compositions, and kits thereof. Further, the description provides a novel method of design and/or synthesis of phosphoryl-derived peptide derivatives useful as therapeutic agents.

专利号:US-6608196-B2
优先权日:2001-05-03
标题 :Process for solid supported synthesis of pyruvate-derived compounds
发明人：WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L
权利人:GALILEO PHARMACEUTICALS INC
摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

专利号:US-7737287-B2
优先权日:2002-03-28
标 题 :Anomeric derivatives of monosaccharides
发明人：MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI
权利人:ALCHEMIA LTD
摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.

专利号:US-9328061-B2
优先权日:2012-03-01
标题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols
发明人：HOVEYDA AMIR H; SILVERIO DANIEL L; PILYUGINA TATIANA; TORKER SEBASTIAN; ROBBINS DANIEL
权利人:TRUSTEES BOSTON COLLEGE
摘要:The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.

专利号:US-2009156828-A1
优先权日:2005-12-21
标题:Novel Compounds and Methods for Forming Taxanes and Using the Same
发明人：HENRI JOHN T; MCCHESNEY JAMES D; VENKATARAMAN SYLESH; SUMNER CHRISTIAN; YIANNIKOUROS GEORGE PETROS; STEMPHOSKI AARON MICHAEL; WALKER DONALD G
权利人:TAPESTRY PHARMACEUTICALS INC
摘要:The present invention is broadly directed to novel compounds useful for the synthesis of biologically active compounds. More particularly, the present embodiments disclosed herein relate to novel side chains, that when coupled to a taxane, are useful for the synthesis of pharmaceutically useful taxanes. Methods of forming the novel side chains and coupling them to hindered alcohols, namely taxanes resulting in useful esters are also disclosed. Various taxanes compounds are known to exhibit anti-tumor activity.