专利号:WO-2011011342-A9 优先权日:2009-07-20 标题:Synthesis of desmopressin 发明人:SRIVASTAVA KRIPA S 权利人:MALLINCKRODT INC; SRIVASTAVA KRIPA S 摘要:The present invention provides a process for the production of desmopressin. In particular, the process provides a process for solid phase synthesis of desmopressin using cyclization of the peptide on the resin.
专利号:WO-2024177606-A1 优先权日:2023-02-24 标 题:Quinazolinone derivative compounds showing anti-cancer activity and the synthesis methods of these compounds 发明人:EVREN ASAF EVRIM; YURTTAS LEYLA; AKALIN CIFTCI GULSEN; SAGLIK BEGUM NURPELIN 权利人:BILECIK SEYH EDEBALI UNIV; ANADOLU UNIV 摘要:The invention relates to quinazolinone-derived compounds that show anticancer activity on the adenocarcinoma human alveolar basal epithelial cell line (A549) by inducing apoptosis in lung cancer cells through inhibition of the epidermal growth factor receptor (EGFR), and at the same time do not have any cytotoxic effects on healthy cells, and to the synthesis methods of these compounds The general structure of the compounds of the invention is shown by Formula (X).
专利号:US-3980631-A 优先权日:1973-11-09 标题:Novel analogs of deamino-vasopressin with a modified disulfide bridge and manufacturing process thereof 发明人:PROCHAZKA ZDENKO; BARTH TOMISLAV; CORT JOSEPH HENRY; JOST KAREL; SORM FRANTISEK 权利人:CESKOSLOVENSKA AKADEMIE VED 摘要:Stepwise synthesis in solution and cyclization by means of active esters or another method suitable for peptide bond formation were used to prepare analogues of deamino-vasopressin with the disulphide bridge altered to the thioether group. In sequence position 8 of the peptide chain the analogs differed by the nature of basic amino acid. Typical vasopressin-like activities, mainly antidiuretic, were very high in these analogs; of particular importance will be their haemodynamic activity.
专利号:CN-115515937-A 优先权日:2020-05-08 标 题:Dimers for the synthesis of peptidomimetics
专利号:WO-2011011342-A1 优先权日:2009-07-20 标题:Synthesis of desmopressin
专利号:CN-114853822-A 优先权日:2022-06-15 标 题 :A kind of oligonucleotide-disulfide and its synthesis method
1: Malve H, Goswami P, Asalkar A, More D. Role of Desmopressin in Bleeding Disorders: What Indian Physicians Need to Know? J Assoc Physicians India. 2025 Jan;73(1):58-60. doi: 10.59556/japi.73.0796. 31(1):8-16. doi: 10.18787/jr.2024.00007. Epub 2024 Mar 31. 3: Everaert K, Holm-Larsen T, Bou Kheir G, Rottey S, Weiss JP, Vande Walle J, Kabarriti AE, Dossche L, Hervé F, Spinoit AF, Nørgaard JP, Juul KV. Potential clinical applications of current and future oral forms of desmopressin (Review). Exp Ther Med. 2024 May 29;28(2):303. doi: 10.3892/etm.2024.12592. 4: Shahzad F, Ahmed U, Muhammad A, Shahzad F, Naufil SI, Sukkari MW, Kamran AB, Murtaza S, Khalid MB, Shabbir H, Saeed S. Safety and efficacy of desmopressin (DDAVP) in preventing hematoma expansion in intracranial hemorrhage associated with antiplatelet drugs use: A systematic review and metaanalysis. Brain Behav. 2024 May;14(5):e3540. doi: 10.1002/brb3.3540.
合成参考文献
摘要:S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (2021) DOI:10.1021/acsenvironau.1c00008. List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355