CAS: 17356-19-3; 1-Ethynylcyclopentanol

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118804-12-9 1462-03-9 155879-96-2

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CAS号120-92-3 环戊酮 | CAS号74-86-2 乙炔 | CAS号71321-24-9 1-[2-(Trimethyl... | CAS号4301-14-8 乙炔基溴化镁 | CAS号1066-26-8 乙炔化钠,二甲苯溶液 | CAS号4301-15-9 acetylene-bis-m... | CAS号62785-89-1 (1-ethynylcyclo... | CAS号70277-75-7 lithium acetyli... | CAS号60-29-7 乙醚 | CAS号104728-36-1 spiro[6,6a-dihy... | CAS号1903-27-1 2-环戊基乙酸 | CAS号1064-10-4 六苯基二锡 | CAS号28638-58-6 1-ethenylcyclop... | CAS号130146-28-0 3-Butyn-2-one,4... | CAS号1528-30-9 亚甲基环戊烷 | CAS号1462-96-0 1-乙基环戊醇 | CAS号16841-19-3 1-羟基-环戊甲酸 | CAS号17160-89-3 1-(1-羟基环戊基)-乙酮

合成工艺路线路线简述

    1-Ethynyl-1-Trimethylsiloxycyclopentane置于乙基溴化镁体系中,用 四氢呋喃 用作溶剂,化学反应 16.0H,反应生成1-乙炔基环戊醇
    参考文献:
    标题:
    摘要:Effects Of Structural Factors In Silyl Ethers Derived From Terminal Acetylenic Alcohols On 1,4-O-->C-Sp Migration Of The Silyl Group In The Iotsitch Reagent Were Studied. The Effect Of Steric Factor At The Carbon Atom Neighboring To The Reaction Center Was Found To Be Stronger Than That At The Silicon Atom In The Migrating Group.
    Doi:10.1023/a:1025529428307

    海关参考信息

    专利信息


    专利号:US-5446203-A
    优先权日:1992-08-25
    标题:Synthesis of haloenones and aryl or alkyl substituted enones or alkenes
    发明人:MCNELIS EDWARD
    权利人:UNIV NEW YORK
    摘要:Alternative methods for synthesizing haloenones and haloakenes and their use as starting materials for synthesis of substituted or unsubstituted alkyl and aryl substituted enones and alkenes, including tamoxifen and tamoxifen analogs, using such haloenones and haloalkenes.

    专利号:US-7109377-B2
    优先权日:1996-10-16
    标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
    发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
    权利人:HARVARD COLLEGE
    摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

    专利号:US-5637757-A
    优先权日:1995-04-11
    标 题 :One-pot synthesis of ring-brominated benzoate compounds
    发明人:HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH
    权利人:GREAT LAKES CHEMICAL CORP
    摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.

    专利号:US-2004053999-A1
    优先权日:1997-09-17
    标题 :Novel compounds and methods for synthesis and therapy
    发明人:BISCHOFBERGER NORBERT W; DAHL TERRENCE C; HITCHCOCK MICHAEL J M; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; MILLS ROGER G; WILLIAMS MATTHEW A
    摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.

    专利号:US-2003082830-A1
    优先权日:1996-10-16
    标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

    专利号:US-6225341-B1
    优先权日:1995-02-27
    标 题:Compounds and methods for synthesis and therapy
    发明人:BISCHOFBERGER NORBERT W; KIM CHOUNG U; LEW WILLARD; LIU HONGTAO; WILLIAMS MATTHEW A
    权利人:GILEAD SCIENCES INC
    摘要:Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibitors of the invention are also described. Methods of inhibiting neuraminidase in samples suspected of containing neuraminidase are also described. Antigenic materials, polymers, antibodies, conjugates of the compounds of the invention with labels, and assay methods for detecting neuraminidase activity are also described.
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    合成参考文献


    摘要:Witt, D., Science of Synthesis Knowledge Updates, (2019) 2, 322.
    摘要:Patil, N. T.; Tathe, A. G.; Bhoyare, V. W., Science of Synthesis, (2019) , 127.
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