CAS: 20776-55-0; 2-Amino-3-Iodobenzoic Acid

该化合物是一种卤化芳香化合物,其特点是氨基氨基磺酸功能组和一个箱式酸功能组,使其成为有机合成的多用途中间体.碘替代体在Suzuki或Ullmann联结等交叉反应中增强了其回动性,而氨基和卡本基组则允许进一步衍生.该化合物对于建造复杂的异性循环周期或作为药用化学的建筑块的制药和农用化学研究特别有用.在标准条件下,它的高纯度和稳定性确保了要求合成应用的可靠性能.由于对光和湿度的潜在敏感性,建议适当处理.

结构式图片

欧盟法规

C&L通报

上下游产品

7-iodoisatin meta-aminobenzoic acid 3-Iodobenzoic acid 2'-hydroxyimino-2-iodoacetanilide 2-(o-methyl phenoxymethyl)-8-iodo anthranil 2-(3,5-Dimethylphenoxymethyl)-8-iodoanthranil 8-Iodo-2-phenyl-benzo[d][1,3]oxazin-4-one 8-Iodo-2-phenoxymethyl-benzo[d][1,3]oxazin-4-one

合成工艺路线路线简述

    7-碘吲哚满二酮置于sodium Hydroxide,双氧水体系中,化学反应生成2-氨基-3-碘苯甲酸
    参考文献:Holt; Sadler,Proceedings Of The Royal Society Of London. Series B,Biological Sciences,1958,Vol. 148,P. 481,488
    标题:Holt; Sadler,Proceedings Of The Royal Society Of London. Series B,Biological Sciences,1958,Vol. 148,P. 481,488

    海关参考信息

    专利信息


    专利号:US-7825244-B2
    优先权日:2005-06-10
    标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
    发明人:BAINDUR NAND; GAUL MICHAEL DAVID; KREUTTER KEVIN DOUGLAS; XU GUOZHANG
    权利人:JANSSEN PHARMACEUTICA NV
    摘要:The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula C: n nwherein R 1 , R 2 , R 99 , and X are as defined herein, the use of such compounds in the synthesis of protein tyrosine kinase inhibitors, particularly inhibitors of FLT3 and/or c-kit and/or TrkB.

    专利号:US-2007021436-A1
    优先权日:2005-06-10
    标 题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis

    专利号:WO-2006135646-A1
    优先权日:2005-06-10
    标题:Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

    专利号:EP-1891040-A1
    优先权日:2005-06-10
    标题 :Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators and related methods of synthesis

    专利号:US-2004138495-A1
    优先权日:1997-10-09
    标题:Combinatorial preparation of phosphorus-containing active compounds and intermediates by solid phase synthesis
    发明人:HAAF KLAUS; PATEK MARCEL
    权利人:HAAF KLAUS; PATEK MARCEL
    摘要:The invention relates to solid phase processes for the systematic preparation of chemical compounds from the group of the phosphonous or phosphinic acids and/or derivatives thereof and the corresponding substance libraries which can be employed for test purposes, in particular tests for biological activity. The compounds n YR 1 P(â•?O)(OR 3 )R 2   (I) n in which Y, R 1 , R 2 , R 3 are as defined in claim 1 are prepared by reacting a resin-linker adduct (II) n [resin polymer]-[linker-Z-E 1 -S 1 ] n n in the presence of a suitable Pd catalyst with a phosphinate (III) n A 1 -O—(PHO)A â–¡   (III) n with substitution of the group S 1 to give the compound (IV) n [resin polymer]-[linker-Z-E 1 -P(H)(â•?O)—OA 1   (IV) n and cleaving the compound (I) after derivatization reactions on the resin from the resin-linker adduct. n The invention also provides the intermediate steps and resin-linked intermediate compounds and also the substance libraries obtained.

    专利号:US-2003108944-A1
    优先权日:1997-10-09
    标 题 :Combinatorial preparations of phosphorus-containing active compounds and intermediates by solid phase synthesis
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