CAS: 3013-27-2; 3-Fluoro-2-Nitrotoluene

上下游产品

CAS号601-87-6 3-甲基-2-硝基苯胺 | CAS号352-70-5 3-氟甲苯 | CAS号443-89-0 2-氨基-3-氟甲苯 | CAS号1227210-35-6 1-溴-4-氟-2-甲基-3-硝基苯

3-甲基-2-硝基苯胺置于tetrafluoroboric Acid,Sodium Nitrite,Silica Gel体系中,化学反应生成3-氟-2-硝基甲苯
参考文献:Selective Small Molecules Blocking Hiv-1 Tat And Coactivator Pcaf Association
标题:Selective Small Molecules Blocking Hiv-1 Tat And Coactivator Pcaf Association
摘要:Development Of Drug Resistance From Mutations In The Targeted Viral Proteins Leads To Continuation Of Viral Production By Chronically Infected Cells,Contributing To Hiv-Mediated Immune Dysfunction. Targeting A Host Cell Protein Essential For Viral Reproduction,Rather Than A Viral Protein,May Minimize The Viral Drug Resistance Problem As Observed With Hiv Protease Inhibitors. We Report Here The Development Of A Novel Class Of N1-Aryl-Propane-1,3-Diamine Compounds Using A Structure-Based Approach That Selectively Inhibit The Activity Of The Bromodomain Of The Human Transcriptional Co-Activator Pcaf,Of Which Association With The Hiv Trans-Activator Tat Is Essential For Transcription And Replication Of The Integrated Hiv Provirus.
Doi:10.1021/ja044885G

专利信息

专利号:US-4721790-A
优先权日:1983-02-25
标 题:Nucleophilic substitution process for fluoronitroaralkyloxazoline
发明人：LILJE KENNETH C
权利人:ETHYL CORP
摘要:Fluoronitroaralkyloxazolines are prepared by reacting a fluoronitroaromatic compound with an alpha-substituted 2-alkyloxazoline in an inert solvent and in the presence of a base. Fluoronitroaralkyloxazolines are useful intermediates for the synthesis of pharmaceuticals, such as flurbiprofen.

专利号:US-4540795-A
优先权日:1983-02-25
标 题:Fluoronitroaralkyloxazolines, derivatives thereof, and nucleophilic substitution processes for preparing them
发明人：LILJE KENNETH C
权利人:ETHYL CORP
摘要:Fluoronitroaralkyloxazolines are prepared by reacting a fluoronitroaromatic compound with an alpha-substituted 2-alkyloxazoline in an inert solvent and in the presence of a base. Fluoronitroaralkyloxazolines are useful intermediates for the synthesis of pharmaceuticals, such as flurbiprofen.