CAS: 41459-42-1; 3-Bromo-2-(Bromomethyl)Propanoic Acid

相似化合物

22262-60-8 58539-11-0 75509-27-2

上下游产品

diethyl bis(hydroxymethyl)malonate diethyl bis(hydroxymethyl)malonate 3-Bromo-2-bromomethyl-propionic acid ethyl ester methyl 3-bromo-2-(bromomethyl)propionate 2-(bromomethyl)acrylic acid α-p-cresoxymethylacrylic acid

二(羟甲基)丙二酸二乙酯置于氢溴酸体系中,化学反应 6.0H,以47%的收率获得产物3-溴-2-溴甲基丙酸
参考文献:Efficient Synthesis Of Methanesulphonate-Derived Lipid Chains For Attachment Of Proteins To Lipid Membranes
标题:Efficient Synthesis Of Methanesulphonate-Derived Lipid Chains For Attachment Of Proteins To Lipid Membranes
摘要:We Have Developed An Easy And Flexible Synthetic Methodology To Obtain Lipid Chains Containing Methanothiosulfonate Terminal Groups With The Aim To Attach Them To Natural Proteins As Functional Groups. There Are Many Proteins Found In Nature That Are Modified By Lipids,And This Is A Key Part Of Their Function. For Example,The Prion Protein Is Attached To The Plasma Membrane Via A Glycosylphosphatidylinositol (Gpi) Anchor,And This Protein Is Thought To Be The Causative Agent In Diseases Such As Bovine Spongiform Encephalopathy (Bse; Mad Cow Disease) And The Human Equivalent Creutzfeldt-Jakob Disease. However,Production Of Large Amounts Of Protein In Bacteria Results In Proteins That Lack These Lipid Modifications. The Lipid Chains Containing Methanothiosulfonate Terminal Groups That We Have Synthesized Here Can Be Attached To These Proteins Through The Thiol Contained In The Side Chain Of The Cysteine Residue,Which Can Be Incorporated Into The Protein Sequence At The Desired Position.
DOI:10.1080/00397910802213794

专利信息

专利号:US-9573934-B2
优先权日:2011-01-26
标题 :Methods and compositions for the synthesis of multimerizing agents
发明人：LI FENG; WANG YIHAN
权利人:ARIAD PHARMA INC
摘要:The invention features methods and compositions for the synthesis of multimerizing agents.

专利号:US-12134630-B2
优先权日:2022-06-21
标 题 :Compositions and methods for liquid phase oligonucleotide synthesis
发明人：YANG GAOMAI; SONG JINGSHE; WANG SHENGDONG; YAO YUN-CHIAO; YANG HONGRONG; YU DAVID; LAU ALDRICH N K
权利人:HONGENE BIOTECH CORP
摘要:Embodiments of the present application relate to polymers used as polymeric polyvalent hubs for liquid phase oligonucleotide synthesis. Methods for making an oligonucleotide by liquid phase oligonucleotide synthesis using the polymers are also provided.

专利号:US-9024028-B2
优先权日:2011-01-26
标题:Methods and compositions for the synthesis of multimerizing agents

专利号:US-2014171649-A1
优先权日:2011-01-26
标 题 :Methods and Compositions for the Synthesis of Multimerizing Agents

专利号:US-2015148543-A1
优先权日:2011-01-26
标题 :Methods and Compositions for the Synthesis of Multimerizing Agents

专利号:WO-2012103279-A2
优先权日:2011-01-26
标题 :Methods and compositions for the synthesis of multimerizing agents