CAS: 4509-90-4; 5-Bromovalerylchloride

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5-溴戊酸置于草酰氯体系中,用 苯 作为反应溶剂,化学反应生成 5-溴戊酰氯
参考文献:游离哌酸作为非核糖体肽的前体
标题:游离哌酸作为非核糖体肽的前体
摘要:哌嗪酸 (Piz) 是一种非蛋白氨基酸,具有稀有的氮-氮键.然而,关于 Piz 如何整合到非核糖体肽中,包括是否存在 Piz 特有的腺苷酸化结构域,我们知之甚少.在这项研究中,我们表明游离哌嗪酸直接腺苷酸化,然后通过同位素掺入研究掺入 Incarnatapeptin 非核糖体肽中.我们也在体外使用重组以证明游离哌嗪酸与来自 Incarnatapeptin 基因簇的三域非核糖体肽合成酶的腺苷酸化.我们还使用生物信息学和定点诱变来概述哌酸腺苷酸化的共有序列,这些序列现在可用于预测与含有哌嗪酸的肽相关的基因簇.最后,我们发现了哌酸合酶和腺苷酸化结构域的融合蛋白,突出了哌酸形成及其腺苷酸化的密切生物合成关系.总而言之,我们的工作证明了通过腺苷酸化激活游离哌酸的生物合成系统的演变,我们认为该途径可能用于大多数含哌嗪酸肽的途径.
DOI:10.1021/jacs.2C03660

专利信息

专利号:US-6159673-A
优先权日:1996-07-17
标 题:Oxonol compound, light-sensitive material and process for the synthesis of oxonol compound
发明人：NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which Z is an atomic group that forms a cyclic amide ring; each of W1 and W2 independently is an atomic group that forms an acidic nucleus ring; and M is a cation. Other oxonol compounds, a light-sensitive material containing an oxonol compound and a process for the synthesis of an oxonol compound are also disclosed.

专利号:EP-1473330-B1
优先权日:1996-07-17
标题:Process for the synthesis of oxonol compound
发明人：NISHIGAKI JUNJI; DEGUCHI YASUAKI
权利人:FUJI PHOTO FILM CO LTD
摘要:An oxonol compound is represented by the following formula (I): in which each of Z, W<1> and W<2> independently is an atomic group that forms a heterocyclic ring; and M is a cation. A process for the synthesis of an oxonol compound is disclosed.

专利号:US-2009264648-A1
优先权日:2008-01-14
标题:Synthesis of pyrazoles
发明人：CHEW WARREN; WANG ZHENG; CHEAL GLORIA; BERTRAND MARTIAL; POTOSKI JOHN; MIRMEHRABI MAHMOUD; NENCINI ARIANNA; ZANALETTI RICCARDO
权利人:WYETH CORP; SIENA BIOTECH SPA
摘要:The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.

专利号:WO-9925385-A1
优先权日:1997-11-17
标 题:A method of increasing nucleic acid synthesis with ultrasound
发明人：UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID
权利人:IMARX PHARMACEUTICAL CORP
摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.

专利号:WO-2009091832-A1
优先权日:2008-01-14
标题 :Synthesis of pyrazoles

专利号:EP-1473330-A1
优先权日:1996-07-17
标题:Process for the synthesis of oxonol compound