专利号:US-2004266699-A1 优先权日:2001-10-04 标 题 :Flavonoid compounds capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells, relative synthesis and their use 发明人:PORTA AMALIA 摘要:The invention relates to flavonoids compounds of formula (I) and (II) capable of modifying the dynamic and/or physical state of biological membranes and to stimulate the endogenous synthesis of stress proteins in eukaryotic cells. Such compounds are molecules of plant origin or synthetic. The invention also describes a method to identify, purify and chemically synthesize such flavonoid compounds and test their efficacy through their capacity to stimulate the transcription of stress genes and as a consequence, to interact with biological membranes with alteration of their relative physical state. Such compounds and corresponding pharmaceutically acceptable derivatives and/or salts have applications in the areas of pharmaceuticals, more specifically in cosmetics and dermatology, for all those afections related to an alteration of the expression of stress genes.
专利号:US-5942494-A 优先权日:1995-10-06 标 题:Stimulation of gene expression and synthesis of heat shock protein 72/73 (HSP 70) 发明人:GINSBERG HENRY N; WU XUJUN; ZHOU MINGYUE 权利人:UNIV COLUMBIA 摘要:This invention provides a method for increasing the level of heat shock protein in a cell which comprises contacting the cell with an effective amount of N-acetyl-leucyl-leucyl-norleucinal, so as to thereby increase the level of heat shock protein in the cell. This invention further provides a protein characterized by increased levels of the protein in a cell in response to contacting the cell with an effective amount of N-acetyl-leucyl-leucyl-norleucinal. This invention also provides a method for increasing the binding of apoprotein B100 to a heat shock protein in a cell. This invention provides a method of preserving an organ ex vivo, which comprises contacting the organ with an effective amount of N-acetyl-leucyl-leucyl-norleucinal. This invention also provides a method of preserving an organ in vivo, which comprises contacting the organ with an effective amount of N-acetyl-leucyl-leucyl-norleucinal.
专利号:US-2002111314-A1 优先权日:1995-10-06 标题 :Novel stimulation of gene expression and protein synthesis of heat shock protein 72/73 (Hsp 70) 发明人:GINSBERG HENRY N; WU XUJUN; ZHOU MINGYUE 权利人:UNIV COLUMBIA 摘要:This invention provides a method for increasing the level of heat shock protein in a cell which comprises contacting the cell with an effective amount of N-acetyl-leucyl-leucyl-norleucinal, so as to thereby increase the level of heat shock protein in the cell. This invention further provides a protein characterized by increased levels of the protein in a cell in response to contacting the cell with an effective amount of N-acetyl-leucyl-leucyl-norleucinal. This invention also provides a method for increasing the binding of apoprotein B100 to a heat shock protein in a cell. This invention provides a method of preserving an organ ex vivo, which comprises contacting the organ with an effective amount of N-acetyl-leucyl-leucyl-norleucinal. This invention also provides a method of preserving an organ in vivo, which comprises contacting the organ with an effective amount of N-acetyl-leucyl-leucyl-norleucinal.
专利号:US-2018351104-A1 优先权日:2012-11-02 标 题:3-substituted tellurophenes and related compounds 发明人:SEFEROS DWIGHT; JAHNKE ASHLEE 权利人:GOVERNING COUNCIL UNIV TORONTO 摘要:Monomeric 3-substituted tellurophene compounds, as well as their use in the synthesis of oligomeric and/or polymeric compounds consisting of two or more tellurophene-2,5-diyl groups which are covalently linked to each other are disclosed, as is the use of said oligomers and polymers in devices such as diodes and solar cells, electrodes and semiconductors.
专利号:US-10059736-B2 优先权日:2005-03-15 标 题 :Ionic liquid supported synthesis 发明人:CHAN TAK-HANG; DAMHA MASAD J; MIAO WEISHI; DONGA ROBERT ALEXANDER; HE XUN 权利人:CHAN TAK HANG; DAMHA MASAD J; MIAO WEISHI; DONGA ROBERT ALEXANDER; HE XUN; UNIV MCGILL 摘要:The present invention relates to ionic liquids for use in chemical applications and capable of serving the dual function of solvent and liquid support. The ionic liquid lends itself to a method of synthesizing oligomers selected from the group consisting of oligopeptides, oligosaccharides and oligonucleotides, comprising contacting a first monomer unit with an ionic liquid at reaction conditions to provide an ionic liquid bound monomer unit; and contacting the ionic liquid bound monomer unit with at least one further monomer unit at reaction conditions to provide an ionic liquid bound oligomer comprising from 2 to 30 monomer units. The method lends itself to large scale manufacture of oligopeptides, oligosaccharides and oligonucleotides.
专利号:WO-2024045401-A1 优先权日:2022-08-30 标题 :Crystal compound, preparation method, and use of same in x-ray direct detection and imaging 发明人:LI BAOYI; ZHENG FAKUN; XIE MEIJUAN; WANG WENFEI; GAO JUAN; GUO GUOCONG 权利人:Mindu Innovation Laboratory; FUJIAN INST RES STR MATTER CAS 摘要:Provided in the present invention are a crystal compound, a preparation method, and the use of same in X-ray direct detection and imaging, relating to the technical field of crystal synthesis. Specifically, the molecular formula of the crystal compound is [M(QS)] n , the structural general formula of the QS being (1) and M representing a metal ion. The compound belongs to tetragonal crystal system and has the space group of P4 2 bc, cell parameters being: a = 17.5559 Ã…, b = 17.5559 Ã…, c = 7.3135 Ã…, α = 90Ëš, β = 105.354Ëš and γ = 90Ëš, Z = 8, and the unit-cell volume being 2254.09(14)Ã… 3 . The crystal compound of the present invention has a simple preparation method. Being used as a material for X-ray detectors, the compound has the characteristics of a large mass attenuation coefficient for X-ray energy, a large carrier mobility-lifetime product, and high X-ray detection sensitivity, and can therefore be used to the fields of semiconductor materials, room-temperature X-ray radiation direct detection materials, radiation detection dosimeters, X-ray semiconductor medical imaging, etc.
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