CAS: 59-58-5; N-((4-Amino-2-Methylpyrimidin-5-yl)Methyl)-N-(5-Hydroxy-3-(Propyldisulfaneyl)Pent-2-En-2-yl)Formamide
该化合物是三胺(维生素B1)的一种合成衍生物,主要用于饮食补充剂和药品,其特点是能够提高三胺的生物利用率,使其在身体中更加有效.Prosultiami是水溶性,具有良好的稳定性,可以用于各种配方,而不会出现显著降解.该化合物以其在碳水化合物代谢中所起的作用而著称,是...
- 英文名称N-((4-Amino-2-Methylpyrimidin-5-yl)Methyl)-N-(5-Hydroxy-3-(Propyldisulfaneyl)Pent-2-En-2-yl)Formamide
- 中文名称丙舒硫胺
- IUPAC名称(E)-N-((4-amino-2-methylpyrimidin-5-yl)methyl)-N-(5-hydroxy-3-(propyldisulfaneyl)pent-2-en-2-yl)formamide
- 其它别名(Propyldithio)-1-Butenyl)-; Alinamin; Prosulthiamine; Thiaminpropyldisulfide; Tiotiamina; Tiovit-B(Sub1); Tipidi; Vitaminb(Sub1)Propyldisulfide
- CAS编号59-58-5
- MFCD编号:MFCD00023265
- EINECS号:200-436-3
- FDA UNII编号:UI32MM3XE3
- 分子式:C15H24N4O2S2
- 分子量:356.52
- 产品CID: 1572588
- 产品分类原料药
物理性质
MSDS等安全信息
上下游产品
CAS号1948-52-3 1-Propanesulfin... | CAS号67-03-8 盐酸硫胺 | CAS号1113-16-2 ethanethiosulfo...合成工艺路线路线简述
维生素b1,Sodium Propylthiosulfate置于sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 1.5H,以65.4 G的收率获得产物丙舒硫胺
参考文献:一种丙硫硫胺的制备方法
标题:一种丙硫硫胺的制备方法
摘要:本发明提供了一种丙硫硫胺的制备方法,其主要采用高速剪切乳化反应装置代替相转移催化剂实现固液两相原料的充分反应,从而实现降低成本,提高生产效率等优点,且使得丙硫硫胺的制备更简单可行,提升企业的竞争能力.
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905121000-正丙醇
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专利信息
专利号:US-2005182036-A1
优先权日:2002-08-02
标题:Medicinal composition containing an HMG-CoA reductase inhibitor
发明人：KONDO TATSUHITO; TAKAGI IKUO; NAKAYAMA MASATO; TORIZUMI YASUHIRO
权利人:SANKYO CO
摘要:A pharmaceutical composition for promoting the synthesis of vascular endothelial nitrogen oxide and/or maintaining or elevating the concentration of vascular endothelial nitrogen oxide in the blood, or a pharmaceutical composition for improving blood lipids. The pharmaceutical composition contains an HMG-CoA reductase inhibitor; and gamma-oryzanol, and/or thiamines. For treatment, the components of the composition can be administered together, as a composition, or separately.
专利号:CN-204447467-U
优先权日:2015-01-14
标 题:A kind of multi-functional filtering device for the synthesis of prothiamin
专利号:JP-2000508544-A
优先权日:1996-04-12
标 题 :Synthesis of human procollagen and collagen in a recombinant DNA system
专利号:WO-2004012740-A1
优先权日:2002-08-02
标题 :MEDICINAL COMPOSITION CONTAINING HMG-CoA REDUCTASE INHIBITOR
发明人：KONDO TATSUHITO; TAKAGI IKUO; NAKAYAMA MASATO; TORIZUMI YASUHIRO
权利人:SANKYO CO; KONDO TATSUHITO; TAKAGI IKUO; NAKAYAMA MASATO; TORIZUMI YASUHIRO
摘要:[Problem] To provide a medicinal composition for promoting the synthesis of vascular endothelial nitrogen oxide and/or maintaining or elevating the concentration of vascular endothelial nitrogen oxide in the blood, or a medicinal composition for improving blood lipids. [Means for Resolution] A medicinal composition which contains an HMG-CoA reductase inhibitor, Ïœ-oryzanol and/or thiamines.
专利号:CN-204589039-U
优先权日:2015-01-14
标题:A high-shear emulsification reaction device for the synthesis of prothiamin
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主要参考文献
1: Matsuo T, Miyata Y, Nakamura T, Satoh K, Sakai H. Prosultiamine for treatment of lower urinary tract dysfunction accompanied by human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis. Int J Urol. 2018 Jan;25(1):54-60. doi: 10.1111/iju.13468. Epub 2017 Oct 1. Japanese. doi: 10.1186/1741-7015-11-183.
4: Nakamura T, Matsuo T, Fukuda T, Yamato S, Yamaguchi K, Kinoshita I, Matsuzaki T, Nishiura Y, Nagasato K, Narita-Masuda T, Nakamura H, Satoh K, Sasaki H, Sakai H, Kawakami A. Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial. BMC Med. 2013 Aug 15;11:182. doi: 10.1186/1741-7015-11-182.
5: Oka H, Tsuzuki K, Takebayashi H, Kojima Y, Daimon T, Sakagami M. Olfactory changes after endoscopic sinus surgery in patients with chronic rhinosinusitis. Auris Nasus Larynx. 2013 Oct;40(5):452-7. doi: 10.1016/j.anl.2012.12.001. Epub 2013 Jan 11. doi: 10.1007/s10548-011-0179-9. Epub 2011 Mar 29. Japanese. Epub 2007 Jul 5.
合成参考文献
摘要:Drugs in Japan, 6(724), 1982
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