CAS: 74137-36-3; 1,3-Dibromo-5-Methoxybenzene

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CAS号67-56-1 甲醇 | CAS号6311-60-0 1,3-二溴-5-硝基苯 | CAS号626-41-5 3,5-二溴苯酚 | CAS号74-88-4 碘甲烷 | CAS号95970-05-1 2,6-二溴-4-甲氧基苯胺 | CAS号1435-51-4 1,3-二溴-5-氟苯 | CAS号124-41-4 甲醇钠 | CAS号626-39-1 1,3,5-三溴苯 | CAS号77-78-1 硫酸二甲酯 | CAS号608-71-9 五溴苯酚 | CAS号56709-70-7 3-溴-5-甲氧基苯甲酸甲酯 | CAS号29578-83-4 1-溴-3-甲氧基-5-甲苯 | CAS号849062-12-0 3-溴-5-甲氧基苯硼酸 | CAS号1050424-08-2 3-borono-5-meth... | CAS号626-41-5 3,5-二溴苯酚 | CAS号100-96-9 5-methoxybenzen... | CAS号262450-65-7 3-溴-5-甲氧基苯甲醛 | CAS号1214369-81-9 5-Methoxy-3-phe... | CAS号1073642-71-3 1-(3-溴-5-甲氧基苯基)乙酮 | CAS号73931-44-9 1,2,5-tribromo-...

2,6-二溴-4-硝基苯胺置于氢氧化钾,硫酸,四丁基溴化铵,1,1,3,3-四甲基脲,Sodium Nitrite体系中,用 乙醇,水 作为反应溶剂,化学反应 27.5H,反应生成 3,5-二溴苯甲醚
参考文献:Anti-Cancer Agents And Uses Thereof
标题:Anti-Cancer Agents And Uses Thereof
摘要:本发明涉及新化合物及其盐,它们的合成以及它们作为抗癌剂的用途.这些化合物包括式i的化合物: 和其溶剂化物,水合物和药用可接受盐,其中a 1 为n或cr 1 ;a 3 为n或cr 3 ;a 5 为n或cr 5 ;r 1,R 3-R 6 和l在规范中定义;n为0或1;x为在环部分具有6-10个碳的可选择取代芳基,在环部分具有1-3个氮原子的可选择取代的6元杂芳基,在环部分具有0-4个氮原子且可选择在环部分有1个硫原子或1个氧原子的可选择取代的5元杂芳基,或者在其中6元环与5元环或6元环融合的可选择取代的杂芳基,其中在每种情况下1,2,3或4个环原子是从氮,氧和硫中独立选择的杂原子.它们对广泛范围的癌症,特别是白血病,前列腺癌,非小细胞肺癌和结肠癌有效.它们还可用于治疗增殖性视网膜病变,如糖尿病神经病变和黄斑变性.

专利信息

专利号:US-2006069260-A1
优先权日:2004-09-28
标 题:Preparation of N-aryl pyridones
发明人：ZHANG HUIPING; CHEN BANG-CHI; ZHAO RULIN
权利人:ZHANG HUIPING; CHEN BANG-CHI; ZHAO RULIN
摘要:A novel process and intermediates thereof for making N-aryl pyridones of the type shown below from appropriate pyridinolates is described. n nThese compounds are useful as intermediates for the synthesis of clinical candidates.

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-8853228-B2
优先权日:2007-06-04
标 题:Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase
发明人：ANDERSON AMY C; WRIGHT DENNIS L; FREY KATHLEEN MARY; PAULSEN JANET LEIGH; SCOCCHERA ERIC WILLIAM; VISWANATHAN KISHORE
权利人:ANDERSON AMY C; WRIGHT DENNIS L; FREY KATHLEEN MARY; PAULSEN JANET LEIGH; SCOCCHERA ERIC WILLIAM; VISWANATHAN KISHORE; UNIV CONNECTICUT
摘要:The compositions and methods described herein disclose the design, synthesis and testing of compounds that act as inhibitors of DHFR. The basic scaffold of these inhibitors includes a 2,4-diaminopyrimidine ring with a propargyl linker to another substituted aryl, bicyclo or heteroaryl ring. These DHFR inhibitors are potent and selective for many different pathogenic organisms, including the DHFR enzyme from bacteria such as Bacillus anthracis and methicillin-resistant Staphylococcus aureus , fungi such as Candida glabrata, Candida albicans and Cryptococcus neoformans and protozoa such as Cryptosporidium hominis and Toxoplasma gondii . These compounds and other similar compounds are also potent against the mammalian enzyme and may be useful as anti-cancer therapeutics.

专利号:US-8426432-B2
优先权日:2007-06-04
标 题 :Inhibitors of dihydrofolate reductase with antibacterial antiprotozoal, antifungal and anticancer properties
发明人：ANDERSON AMY C; WRIGHT DENNIS L; PELPHREY PHILLIP M; JOSKA TAMMY M; BOLSTAD ERIN S D; BOLSTAD DAVID B; POPOV VELJKO
权利人:ANDERSON AMY C; WRIGHT DENNIS L; PELPHREY PHILLIP M; JOSKA TAMMY M; BOLSTAD ERIN S D; BOLSTAD DAVID B; POPOV VELJKO; UNIV CONNECTICUT
摘要:The compositions and methods described herein discloses the design, synthesis and testing of compounds that act as inhibitors of DHFR. The basic scaffold of these inhibitors includes a 2,4-diaminopyrimidine ring with a propargyl linker to another substituted aryl, bicyclo or heteroaryl ring. These DHFR inhibitors are potent and selective for many different pathogenic organisms, including the DHFR enzyme from bacteria such as Bacillus anthracis and methicillin-resistant Staphylococcus aureus , fungi such as Candida glabrata, Candida albicans and Cryptococcus neoformans and protozoa such as Cryptosporidium hominis and Toxoplasma gondii . These compounds and other similar compounds are also potent against the mammalian enzyme and may be useful as anti-cancer therapeutics.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:US-7166619-B2
优先权日:2002-08-14
标题 :Prenylation inhibitors and methods of their synthesis and use
发明人：LI FRANCINE FEIRONG; REHDER KENNETH S; CAMPBELL MICHAEL GORDON; VISCARDI CELESTE PATRICE; STRACHAN JON-PAUL; GUO ZHENGMING
权利人:PPD DISCOVERY INC
摘要:The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.