专利号:US-2013035307-A1 优先权日:2010-01-26 标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers 发明人:PRESTWICH GLENN D; KENNEDY THOMAS P 权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P 摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.
专利号:US-4129648-A 优先权日:1977-11-21 标 题 :Method for reducing endogenous prostaglandin synthesis 发明人:COLLIER HARRY O J; SAEED SHEIKH A; SCHNEIDER CYRIL; MANNUZZA FRANK 权利人:COLLIER HARRY O J; SAEED SHEIKH A; SCHNEIDER CYRIL; MANNUZZA FRANK 摘要:A high molecular weight extract of mammalian blood plasma and serum proteins of the group Cohn fraction IV, Cohn subfraction IV1, IV4 and haptoglobin, have been found to contain activity which inhibits endogenous prostaglandin synthetase. This extract is therefore of utility in treating or alleviating pathological conditions associated with excessive or unbalanced snythesis of endogenous prostaglandins, for example, in reducing bronchoconstriction or treating arthritis. For this purpose, the extract may be administered by injection, by inhalation, or topically.
专利号:KR-20160017105-A 优先权日:2008-01-15 标题:Synthesis of resorcylic acid lactones useful as therapeutic agents
专利号:KR-20110003468-A 优先权日:2008-01-15 标题:Synthesis of resorcylic acid lactones useful as therapeutic agents
专利号:WO-2009091921-A1 优先权日:2008-01-15 标题:Synthesis of resorcylic acid lactones useful as therapeutic agents
专利号:JP-6159350-B2 优先权日:2008-01-15 标 题:Synthesis of resorcinic acid lactones useful as therapeutic agents
1: Nalamachu S, Wortmann R. Role of indomethacin in acute pain and inflammation management: a review of the literature. Postgrad Med. 2014 Jul;126(4):92-7. doi: 10.3810/pgm.2014.07.2787. Review. doi: 10.2147/CPAA.S59376. eCollection 2014. Review. 3: Sethi S, Sethi N, Wadhwa V, Garud S, Brown A. A meta-analysis on the role of rectal diclofenac and indomethacin in the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis. Pancreas. 2014 Mar;43(2):190-7. doi: 10.1097/MPA.0000000000000090. Review. doi: 10.1007/s40272-013-0031-7. Review. doi: 10.1007/s11916-013-0327-x. Review. doi: 10.1111/ped.12037. Review. Indomethacin prevents post-ERCP pancreatitis in selected high-risk patients. Intern Emerg Med. 2012 Dec;7(6):557-8. doi: 10.1007/s11739-012-0872-z. Epub 2012 Nov 2. Review. Review. doi: 10.1159/000335332. Epub 2012 Mar 8. Review. doi: 10.1016/j.clp.2011.12.002. Epub 2012 Jan 13. Review. 11: Anabrees JA, Aifaleh KM. Fluid restriction and prophylactic indomethacin in extremely low birth weight infants. J Clin Neonatol. 2012 Jan;1(1):1-5. doi: 10.4103/2249-4847.92228. Review.