CAS: 113-80-4; (S)-N-((S)-1-((2-Amino-2-Oxoethyl)Amino)-5-((Diaminomethylene)Amino)-1-Oxopentan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-Amino-2-Oxoethyl)-10-(3-Amino-3-Oxopropyl)-13-((S)-Sec-Butyl)-16-(4-Hydroxybenzyl)-6,9,12,15,18-Pentaoxo-1,2-Dithia-5,8,11,14,17-Pentaazacycloicosane-4-Carbonyl)Pyrrolidine-2-Carboxamide
该化合物是一种作为血管消毒器并主要用于研究环境的合成浸泡物,以其模仿某些内生浸泡物的能力而著称,它影响血管顺利肌肉放松,并有可能影响血液流动动态;该物质的特点为特定氨基酸序列,有助于其生物活动;Argiprestovicin经常研究其对心血管功能的影响及其在与血管健康有关的条件下的潜在治疗应用;作为浸泡物,它通常可溶于水溶液中,可能需要小心处理才能保持其稳定性;其药理学特征包括与特定受体的相互作用,导致各种生理反应;然而,有关其安全性,功效和临床应用的详细信息有限,因为它主要用于实验环境而不是广泛的临床用途.
- 英文名称(S)-N-((S)-1-((2-Amino-2-Oxoethyl)Amino)-5-((Diaminomethylene)Amino)-1-Oxopentan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-Amino-2-Oxoethyl)-10-(3-Amino-3-Oxopropyl)-13-((S)-Sec-Butyl)-16-(4-Hydroxybenzyl)-6,9,12,15,18-Pentaoxo-1,2-Dithia-5,8,11,14,17-Pentaazacycloicosane-4-Carbonyl)Pyrrolidine-2-Carboxamide
- 中文名称精氨缩宫素
- IUPAC名称(S)-N-((S)-1-((2-amino-2-oxoethyl)amino)-5-((diaminomethylene)amino)-1-oxopentan-2-yl)-1-((4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-((S)-sec-butyl)-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)pyrrolidine-2-carboxamide
- 其它别名(Arg(Sup 8))Oxytocin; 8-L-Arginineoxytocin; Unii-W6S6Ury8Of; Argiprestocina [inn-Spanish]; Argiprestocine [inn-French]; Arginine Vasotocin; 3,4-Dihydro-2H-Phenantren-1-One; 9-Glycinamide-1-9-Hydrin 2 (Peptide)
- CAS编号113-80-4
- MFCD编号:MFCD00076755
- EINECS号:812-989-3
- FDA UNII编号:W6S6URY8OF
- 分子式:C43H67N15O12S2
- 分子量:1050.24
- 产品CID: 169894
- 产品分类生物化工 → 多肽
物理性质
MSDS等安全信息
欧盟法规
C&L通报合成工艺路线路线简述
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主要参考文献
1: Yousef M, Moudilou EN, Kadji H, Exbrayat JM. Study of the hydromineral regulation of Typhlonectes compressicauda according to the seasonal variation. Folia Histochem Cytobiol. 2018 Aug 2. doi: 10.5603/FHC.a2018.0016. [Epub ahead of print] doi: 10.1016/j.yhbeh.2018.06.006. Epub 2018 Jun 22. doi: 10.3389/fendo.2018.00157. eCollection 2018.
10: Kang SW, Jayanthi S, Nagarajan G, Suresh Kumar TK, Kuenzel WJ. Identification of avian vasotocin receptor subtype-specific antagonists involved in the stress response of the chicken, Gallus gallus. J Biomol Struct Dyn. 2018 May
17:1-15. doi: 10.1080/07391102.2018.1464957. [Epub ahead of print] doi: 10.1016/j.ijoa.2018.03.004. Epub 2018 Mar 15. doi: 10.3389/fendo.2018.00063. eCollection 2018. Erratum in: Front Endocrinol (Lausanne). 2018 Apr 06;9:157.
合成参考文献
参考文献:10.1016/0742-8413(96)00018-7
摘要:Silveira PF, Mimura OM. l-Cystine-di-beta-naphthylamidase activity in plasma of the snake Bothrops jararaca after chronic challenges of water balance. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. 1996 Jul;114(3):185–92. doi: 10.1016/0742-8413(96)00018-7.
参考文献:10.1007/s002329900130
摘要:Nakahari T, Marunaka Y. ADH Action on Whole-Cell Currents by Cytosolic Ca 2+ -dependent Pathways in Aldosterone-treated A6 Cells. Journal of Membrane Biology. 1996 Nov 01;154(1):35–44. doi: 10.1007/s002329900130.
参考文献:10.1007/bf00301128
摘要:Simon E, Schmid HA. Effects of angiotensin II and its blockers Sar1-lle8-angiotensin II and DuP 753 on drinking in ducks in relation to properties of subfornical organ neurons. Journal of Comparative Physiology B. 1996 Mar;165(8):607–14. doi: 10.1007/bf00301128.
参考文献:10.1007/bf00301129
摘要:Schmid HA, Simon E. Vasotocin acts as a dipsogen in ducks at concentrations stimulating subfornical organ neurons in vitro. Journal of Comparative Physiology B. 1996 Mar;165(8):615–21. doi: 10.1007/bf00301129.
参考文献:10.1002/(sici)1097-4695(199610)31:2<129::aid-neu1>3.0.co;2-d|10.1002/(sici)1097-4695(199610)31:2<129::aid-neu1>3.3.co;2-2
摘要:Balthazart J, Absil P, Foidart A, Houbart M, Harada N, Ball GF. Distribution of aromatase-immunoreactive cells in the forebrain of zebra finches (Taeniopygia guttata): implications for the neural action of steroids and nuclear definition in the avian hypothalamus. J Neurobiol. 1996 Oct;31(2):129–48. doi: 10.1002/(sici)1097-4695(199610)31:2<129::aid-neu1>3.0.co;2-d.
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