CAS: 136888-79-4; 2-Fluoro-5-Methoxypyridine

相似化合物

163234-74-0 55758-32-2 1443679-87-5

上下游产品

6-fluoropyridin-3-ol methyl iodide (6-fluoropyridin-3-yl)boronic acid2-fluoro-5-methoxynicotinic acid 2-(4-bromophenoxy)-5-methoxynicotinic acid

2-氟-5-吡啶硼酸置于potassium Carbonate,Sodium Hydroxide体系中,用 四氢呋喃,N,N-二甲基甲酰胺 用作溶剂,化学反应 6.0H,反应生成2-氟-5-甲氧基吡啶
参考文献: Spiro-Amino-Imidazo-Fused Heterocyclic Compounds As Beta-Secretase Modulators And Methods Of Use[fr] Composés Hétérocycliques Spiro-Amino-Imidazo-Condensés En Tant Que Modulateurs De La Bêta-Secrétase Et Méthodes D'Utilisation
标题: Spiro-Amino-Imidazo-Fused Heterocyclic Compounds As Beta-Secretase Modulators And Methods Of Use[fr] Composés Hétérocycliques Spiro-Amino-Imidazo-Condensés En Tant Que Modulateurs De La Bêta-Secrétase Et Méthodes D'Utilisation
摘要:本发明提供了一类新的化合物,用于调节β-分泌酶(bace)活性.这些化合物具有一般的化学式i,其中化学式i中的变量a1,A3,A4,A5,A6,A8,R2,R7,X,Y和z在此处被定义.本发明还提供了包括这些化合物的药物组合物,以及这些化合物和组合物用于治疗与斑块形成和沉积相关的疾病和/或症状的对应用途,这些疾病和症状是由bace的活性引起的.这种由bace介导的疾病包括阿尔茨海默病,认知缺陷和损伤,精神分裂症和其他中枢神经系统疾病.本发明还提供了化学式ii和iii的化合物,以及化学式i,Ii和iii的亚式化合物,中间体和有用于制备化学式i-Iii的化合物的过程和方法.

专利信息

专利号:WO-2024159287-A1
优先权日:2023-01-30
标 题:Nav1.7- and/or nav1.8-inhibiting hydroxamates, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The invention relates to Nav1.7- and/or Nav1.8-inhibiting hydroxamates. More specifically, the present invention relates to hydroxamates that comprise formula (I): (I), in which the substituents R1 to R10, as well as the derivatives thereof, R11 to R20, are selected independently of the groups defined in the description, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.

专利号:WO-2024159285-A1
优先权日:2023-01-30
标题 :Nav1.7- and/or nav1.8-inhibiting aryl pyridine compounds, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting aryl pyridine compounds. More specifically, the present invention relates to aryl pyridines comprising formula (I): (I), in which the substituents R1 to R10 are selected independently of the groups defined in the description, as well as to processes for preparing same, compositions comprising at least one of these compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related diseases.