CAS: 35590-37-5; 5-Bromonicotinonitrile

相似化合物

113118-81-3 20826-04-4 28733-43-9

上下游产品

5-bromonicotinamide 5-bromo-3-pyridinecarboxylic acid sodium hydrogencarbonate 3-bromopyridine N-oxide ethyl-(5-cyano-3-pyridyl)carboxylate 5-phenylnicotinonitrile 5-(5-cyanopyridin-3-yl)-furan-2-carbaldehyde 5-(3-{[(2-cyclopentyl-6,7-dimethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]methyl}phenyl)nicotinonitrile

3,5-二溴吡啶置于异丙基氯化镁,Lithium Chloride,N,N-二甲基甲酰胺,氨,碘体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 4.25H,以68%的收率获得产物5-溴烟腈
参考文献:实用的一锅法将芳基溴化物和β-溴苯乙烯转化为芳族腈和肉桂腈
标题:实用的一锅法将芳基溴化物和β-溴苯乙烯转化为芳族腈和肉桂腈
摘要:通过用mg车削和随后的dmf处理,然后用分子碘和nh 3水溶液处理,各种芳基溴化物以非常好的产率有效地转化为相应的芳族腈.相同的处理芳基溴化物,其是弱反应到mg屑,与我prmgcl.licl并随后dmf,接着用分子碘治疗和水溶液nh 3也得到相应的芳香腈以非常好的收率.另一方面,当使用n-甲酰基哌啶代替dmf时,对位取代的β-溴苯乙烯被转化为相应的对位取代的肉桂腈,即α,β-不饱和腈,通过相同的方法具有非常好至中等的收率.该反应通过简单的实验程序进行,不需要任何有毒的金属氰化物或昂贵的稀有金属.因此,本反应是实用的,对环境有益的一锅法,可通过形成格氏试剂及其dmf或dmf分别由芳基溴化物,β-溴苯乙烯和烷基溴化物制备芳族腈,肉桂腈和脂族腈.n-甲酰基哌啶加合物.
DOI:10.1016/j.Tet.2012.12.022

专利信息

专利号:US-9549917-B2
优先权日:2011-09-08
标 题 :Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; LAI ZHONG; DANG QUN; ZORN NICOLAS
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; LAI ZHONG; DANG QUN; ZORN NICOLAS; MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9744252-B2
优先权日:2011-08-17
标 题:Compounds for binding to the platelet specific glycoprotein IIb/IIIa and their use for imaging of thrombi
发明人：BERGER MARKUS; KRUGER MARTIN; LOHRKE JESSICA; REINHARDT MICHAEL; SIEBENEICHER HOLGER
权利人:PIRAMAL IMAGING SA
摘要:The present invention relates to novel fluorine containing compounds, methods for their preparation, the intermediates of the synthesis, their use as diagnostic agents, especially for imaging of thrombi. The invention relates to positron emission tomography (PET) agents and associated precursor reagents, and methods for producing such radiolaveled agents for imaging of thrombi in a mammalian body. More particularly, the invention relates to small nonpeptide, high-affinity, specific-binding glycoprotein IIb/IIIa antagonists for imaging of thrombi.

专利号:US-2011152295-A1
优先权日:2008-09-08
标 题:Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
权利人:LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:US-2025011313-A1
优先权日:2021-10-28
标 题:Ccr6 receptor modulators
发明人：ALLEMANN OLIVER; HUBLER FRANCIS; MEYER EMMANUEL
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.

专利号:US-2025042881-A1
优先权日:2021-10-26
标 题 :Ccr6 receptor modulators
发明人：ALLEMANN OLIVER; CAROFF EVA; HUBLER FRANCIS; MEYER EMMANUEL
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR6 receptor modulators for the prevention or treatment of e.g. inflammatory/autoimmune diseases/disorders and cancer.