CAS: 52-01-7; Spironolactone

上下游产品

thioacetic acid canrenone tiolacetic acid levonorgestrel canrenone Chloronone 3-oxo-17α-pregna-4-ene-7α-[4-(t-butyldimethylsilyloxy)-benzylthia]-21,17-carbolactone 7-Thiomethylspirolactone

3-乙氧基-雄甾-3,5-二烯-17-酮置于三氟甲磺酸酐,C30H31Cl3N3(1+)*bf4(1-),四氯苯醌,三乙胺,Lithium Bromide体系中,用 四氢呋喃,甲醇,水,1,2-二氯乙烷 作为反应溶剂,化学反应 7.0H,反应生成 螺内酯
参考文献:一种制备螺内酯的方法
标题:一种制备螺内酯的方法
摘要:本发明公开了一种制备螺内酯的方法,包括下列步骤:步骤1,将式(II)化合物与丙烯醛在催化剂,碱及路易斯酸作用下反应,得到式(Iii)化合物;步骤2,将式(Iii)化合物与氯醌反应,制得(Iv)化合物;步骤3,将式(Iv)化合物与硫代乙酸发生加成即制得螺内酯.本发明提供的螺内酯的制备方法具有合成路线短,所用的试剂价廉,易得,操作简单,总收率高,适于工业化生产的优点;为制备螺内酯提供了一条新的途径.

专利信息

专利号:US-12383499-B2
优先权日:2018-01-01
标题:Scale up synthesis of silicasome nanocarriers
发明人：NEL ANDRE E; MENG HUAN; LIU XIANGSHENG
权利人:UNIV CALIFORNIA
摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).

专利号:EP-0269236-B1
优先权日:1986-10-24
标题:Process for synthesis of a chiral azetidinone
摘要:A process is described for the stereo-controlled synthesis of 3-(R)-3-[1'-(R)-hydroxyethyl]-4-(R)-benzoyl-2-oxo-1-aze tidines and their derivatives which are useful intermediates in the synthesis of carbapenem antibiotics.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-6127489-A
优先权日:1996-05-20
标题:Silyl linker for solid phase organic synthesis of aryl-containing molecules
发明人：NEWLANDER KENNETH A; MOORE MICHAEL L
权利人:SMITHKLINE BEECHAM CORP
摘要:This invention relates to improved silyl linkers, methods for their preparation and their use in the solid phase synthesis of aromatic carbocycles, especially electron deficient aromatic carbocycles.

专利号:US-10973847-B2
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
发明人：JOHNSON JEREMIAH A; GOLDER MATTHEW R
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.