CAS: 619-55-6; 4-Methylbenzamide

上下游产品

4-methyl-benzoic acid methyl ester 4-methyl-benzoyl chloride para-methylbenzonitrile potassium thioacyanatebenzonitrile benzoic acid N-(4-methylbenzoyl)benzamide para-methylbenzonitrile

对甲基苯甲酸乙酯置于indium(Iii) Chloride,Calcium Nitride体系中,用 乙醇 作为反应溶剂,化学反应 1.5H,以76%的收率获得产物对甲苯酰胺
参考文献:伯酰胺的机械化学合成
标题:伯酰胺的机械化学合成
摘要:将芳香族,杂芳香族,乙烯基和脂肪族酯与乙醇和氮化钙球磨,在与各种官能团相容的转化中提供相应的伯酰胺,并保持立体中心α到羰基的完整性.该方法适用于 α-氨基酯和n-Boc 二肽酯,也适用于抗癫痫药物卢非酰胺的合成.
DOI:10.1021/acs.Joc.1C02350

专利信息

专利号:US-5919969-A
优先权日:1996-06-05
标 题 :Synthesis of yellow couplers
发明人：CRAWLEY MICHAEL W
权利人:EASTMAN KODAK CO
摘要:The invention provides a method of synthesis of a image-dye forming coupler of formula (I) wherein X is a substituent linked to the coupler by an atom of oxygen, sulfur or nitrogen R1 is an alkyl or aryl group, R2 is a hydrogen atom or an alkyl group; R3 to R7 are the same or different and selected from a hydrogen atom and substituent groups; which method comprises the reaction of a compound of formula (II) wherein R and R1 are the same or different and are as defined above for R1 and X is as defined above with a compound of formula (III) wherein R2 to R7 are as defined above, in the presence of an inert organic solvent.

专利号:US-7368568-B2
优先权日:2001-08-03
标 题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for production and the use
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:BAYER SCHERING PHARMA AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroarnides for the synthesis of edothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-6933385-B2
优先权日:2001-08-03
标题 :Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
发明人：WESTERMANN JURGEN; PLATZEK JOHANNES; PETROV ORLIN
权利人:SCHERING AG
摘要:The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.

专利号:US-7781488-B2
优先权日:2002-06-10
标 题:Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation
发明人：BOTTI PAOLO; VILLAIN MATTEO; MANGANIELLO SONIA; GAERTNER HUBERT
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The present invention provides a method and compositions for synthesizing an oligopeptide or polypeptide by convergent assembly of a plurality of pairs of oligopeptides in chemical ligation reactions. An important aspect of the present invention is an oligopeptide having a C-terminal disulfide-protected carboxythioester group that can be deprotected to spontaneously generate a free C-terminal thioester moiety. This allows a single precursor to participate in a succession of chemical ligation reactions, thereby making the convergent synthesis approach possible. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins, and improves the efficiency of native chemical ligation reactions, particularly where four or more peptide fragments are used to assemble an oligopeptide, polypeptide or protein product.

专利号:US-9908846-B2
优先权日:2014-02-21
标题:Composition, synthesis, and use of new arylsulfonyl isonitriles
发明人：FLEMING FRASER FERGUSSON; LUJAN MONTELONGO JESUS ARMANDO
权利人:DUQUESNE UNIV OF THE HOLY GHOST; UNIV HOLY GHOST DUQUESNE
摘要:This invention relates to novel isonitriles, including arylsulfonyl isonitriles, and methods for their synthesis. The isonitriles include a conjugated ring system. The structure is designed with the flexibility to have multiple substitution patterns. The isonitriles may be used in applications including, but not limited to, pharmaceutical compositions.

专利号:US-2020190135-A1
优先权日:2016-11-16
标题 :Lasso structures and their synthesis
发明人：BODE JEFFREY; SAITO FUMITO
权利人:CHROMACON AG
摘要:A method for the synthesis of a molecular lasso structure in which a linear moiety is covalently attached to a cyclic moiety and with its free end is partially threaded through the orifice formed by the cyclic moiety, including the following steps: 1) provision of a cyclic and a first linear structural element and establishing conditions in which the first linear structural element is threaded through the orifice of the cyclic moiety; 2) covalently attaching a stopper element to one terminal end of the linear structural element; 3) separating unthreaded from threaded molecular assemblies by chemical or physical separation; and 4) reacting the threaded molecular assemblies with a second linear structural element so that it is covalently attached to the first linear structural element at its end opposite to the end where the stopper is attached, and so that the second linear structural element is covalently attached to the cyclic moiety.