CAS: 6850-39-1; 3-Aminocyclohexanol

相似化合物

1849594-88-2 1263378-29-5 2007915-63-9

上下游产品

CAS号764-59-0 5-HEXENAL | CAS号621-42-1 3'-羟基乙酰苯胺 | CAS号13941-94-1 N-(3-羟基环己基)苯甲酰胺 | CAS号721884-81-7 (1S,3S)-3-氨基环己醇 | CAS号721884-82-8 (1R,3R)-3-Amino... | CAS号764-59-0 5-HEXENAL | CAS号955406-36-7 苄基(3-羟基环己基)氨基甲酸酯

5-己烯醛置于sodium Hydroxide,三氟甲磺酸三甲基硅酯体系中,用 四氯化碳,乙醚 作为反应溶剂,化学反应 32.0H,反应生成 3-氨基环己醇
参考文献:Reactions Of 1-Acylamino-1-(Trimethylsiloxy)Alkanes: Versatile Precursors To Acylimines
标题:Reactions Of 1-Acylamino-1-(Trimethylsiloxy)Alkanes: Versatile Precursors To Acylimines
摘要:1-酰氨基-1-(三甲基硅氧基)烷烃与碳和杂原子亲核试剂反应,反应生成相应的1-取代-1-酰氨基烷烃.1-酰氨基-1-(三甲基硅氧基)烷烃还可以反应生成烯酰胺,通过这种途径,可以制备出温和的抗生素肽霉素及其异构体(Z)-肽霉素.它们反应的另一个例子是酸催化的分子内环化反应,发生在碳-碳双键上.这些转化表明,1-酰氨基-1-(三甲基硅氧基)烷烃是合成有用酰亚胺的多功能前体.
DOI:10.1039/p19960000895

专利信息

专利号:EP-3325432-B1
优先权日:2015-07-24
标题:Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein

专利号:WO-2017019487-A1
优先权日:2015-07-24
标 题:Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:US-9370515-B2
优先权日:2013-03-07
标题 :Mixed lineage kinase inhibitors and method of treatments
发明人：GOODFELLOW VAL S; NGUYEN THONG X; RAVULA SATHEESH B; GELBARD HARRIS A
权利人:CALIFIA BIO INC; UNIV ROCHESTER
摘要:Provided herein are imidazopyridine compounds having an inhibitory effect on mixed lineage kinases (MLKs), methods of their synthesis, and methods of their therapeutic. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and pharmaceutical compositions.

专利号:EP-3795553-A1
优先权日:2015-07-24
标 题 :Methods of synthesis of (1r,2r,5r)-5-amino-2-methylcyclohexanol hydrochloride and intermediates useful therein

专利号:CN-116102543-A
优先权日:2022-10-21
标题 :A kind of GLP-1R agonist, synthesis method and use thereof