CAS: 77-60-1; (2As,4S,5'R,6As,6Bs,8As,8Br,9S,10R,11As,12As,12Br)-5',6A,8A,9-Tetramethyldocosahydrospiro[naphtho[2',1':4,5]Indeno[2,1-B]Furan-10,2'-Pyran]-4-Ol

上下游产品

CAS号512-04-9 薯蓣皂苷元 | CAS号915-35-5 乙酸龙舌兰皂苷酯 | CAS号690275-05-9 (E)-1-(tert-but... | CAS号110124-76-0 (25R)-5α-spiros... | CAS号35959-24-1 (25R)-5α-spiros... | CAS号17916-30-2 Pregn-5-en-20-o... | CAS号571-20-0 5α-雄烷二醇 | CAS号1169-20-6 (3S,5S,8R,9S,10... | CAS号1239-31-2 醋酸去氢表雄酮

薯蓣皂素置于palladium On Activated Charcoal 氢气,溶剂黄146体系中,用 乙醇,二氯甲烷 作为反应溶剂,20.0 °C,101.32 Kpa 条件下,反应 12.0H,以93%的收率获得产物剑麻皂素
参考文献:Synthesis Of The Cytotoxic Gitogenin 3β-O-[2-O-(α-L-Rhamnopyranosyl)-β-D-Galactopyranoside] And Its Congeners
标题:Synthesis Of The Cytotoxic Gitogenin 3β-O-[2-O-(α-L-Rhamnopyranosyl)-β-D-Galactopyranoside] And Its Congeners
摘要:(25R)-5A-螺甾-2A,3B-二醇 (Gitogenin) 3β-O-[2-O-(α-L-鼠李吡喃糖基)-β-D-半乳吡喃糖苷] (1),一种从长茎黄精(百合科)地下部分分离得到的细胞毒性螺甾皂苷,被简明地合成出来.在此过程中,其类似物2-4也被制备出来.所有四个化合物在抑制癌细胞生长方面与薯蓣皂苷具有相当的效力.
DOI:10.1055/s-2006-926316

专利信息

专利号:US-5807834-A
优先权日:1994-09-20
标 题 :Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor
发明人：MOREHOUSE LEE A
权利人:PFIZER
摘要:PCT No. PCT/IB95/00447 Sec. 371 Date Mar. 18, 1997 Sec. 102(e) Date Mar. 18, 1997 PCT Filed Jun. 7, 1995 PCT Pub. No. WO96/09827 PCT Pub. Date Apr. 4, 1996Pharmaceutical combination compositions including certain cholesterol absorption inhibitors and cholesterol synthesis inhibitors. The compositions are useful for the treatment of hypercholesterolemia and atherosclerosis.

专利号:EP-3002290-B1
优先权日:2007-06-19
标 题:Synthesis of deoxycholic acid (dca)
发明人：MORIARTY ROBERT M; DAVID NATHANIEL E; MAHMOOD NADIR AHMEDUDDIN; PRASAD ACHAMPETA RATHAN; SWARINGEN ROY A JR; REID JOHN GREGORY; SAHOO AKHILA KUMAR
权利人:ALLERGAN SALES LLC

专利号:US-5606041-A
优先权日:1992-06-26
标题:Process for steroidal peracyl glycosides
发明人：BUSCH FRANK R; GOGGIN KATHLEEN D; LAMBERT JOHN F; SHINE RUSSELL J; WALINSKY STANLEY W
权利人:PFIZER
摘要:Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypo-cholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting α-cellobiosyl bromide heptaalkanoate and β-tigogenin in the presence of zinc fluoride or zinc cyanide under conditions capable of forming said tigogenyl β-O-cellobioside heptaalkanoate. The analogous preparations of hecogenin β-O-cellobioside heptaalkanoate 11-ketotigogenin β-O-cellobioside heptaalkanoate, and diosgenin β-O-cellobioside heptaalkanoate are also disclosed. The process provides both high β-anomeric selectivity and high yields.

专利号:EP-3002290-A2
优先权日:2007-06-19
标 题 :Synthesis of deoxycholic acid (dca)

专利号:CN-1401658-A
优先权日:2002-09-13
标题 :Process for synthesis of 2,4-O-di-alpha-L-pyranorhamnosyl-beta-D-pyranoglucosyldioscin

专利号:US-5530107-A
优先权日:1992-10-15
标 题:Method for making steroidal peracyl glycosides
发明人：ALLAN DOUGLAS J M; BUSCH FRANK R; LAMBERT JOHN F; SHINE RUSSELL J; WALINSKY STANLEY W
权利人:PFIZER
摘要:Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypocholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting α-cellobiosyl bromide heptaalkanoate and β-tigogenin in the presence of zinc fluoride or zinc cyanide under conditions capable of forming said tigogenyl β-O-cellobioside heptaalkanoate. The analogous preparations of hecogenin β-O-cellobioside heptaalkanoate, 11-ketotigogenin β-O-cellobioside heptaalkanoate, and diosgenin β-O-cellobioside heptaalkanoate are also disclosed. The process provides both high β-anomeric selectivity and high yields.