CAS: 811-51-8; Sodium Ethanethiolate

该化合物是一种乙二醇钠盐,通常用作核素或有机合成的基质.其很强的核素性能使其对硫化反应很有价值,特别是在准备含硫化合物时.该化合物具有高度反应性,在制药和农用化学应用中能够高效地进行通灵和替代过程.它通常作为白色供应到非白色粉末或溶液中,在惰性条件下保持稳定.乙酰胺有利于其将乙醇组引入分子框架的能力,有利于硫醚和其他有机硫衍生物的合成.在水下进行适当处理,由于对水分和空气的敏感性,是不可或缺的.

结构式图片

欧盟法规

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合成工艺路线路线简述

    2-(Ethylthio)Benzonitrile置于盐酸,水,氯,Sodium Hydrogen Sulfide,四丁基溴化铵体系中,用 氯苯,水 作为反应溶剂,化学反应 10.0H,以74 G的收率获得产物乙硫醇钠
    参考文献:Ep2687520
    标题:Ep2687520

    海关参考信息

    专利信息


    专利号:US-5247099-A
    优先权日:1989-08-17
    标题:Process for synthesis of 7-hydroxy coumarins having substitutions in the 4-position
    发明人:CELEBUSKI JOSEPH E
    权利人:ABBOTT LAB
    摘要:A process for synthesis of a compound of the formula: said process comprising the steps of (a) reacting 4-bromomethyl-7-methoxy coumarin with a malonic ester under conditions sufficient to achieve condensation of the ester to give the monoalkylated (2-bis(carbalkoxy)-2-R1-1-ethyl) derivative; (b) removing one of the carbalkoxy groups from the product of step (a); (c) demethylation of the product of step (b) to give the 7-hydroxycoumarin compound; and (d) chemically modifying the remaining ester to yield a desired R2.

    专利号:US-6492136-B1
    优先权日:1995-12-07
    标题 :Solid phase organic synthesis
    发明人:FLITSCH SABINE LAHJA; TURNER NICHOLAS JOHN
    权利人:GENZYME LTD
    摘要:A method of synthesis of a material corresponding to the general formula:characterized in that it comprises a material corresponding to the following general formula:being cleaved as indicated enzymatically or non-enzymatically using acid catalysis in the presence of a nucleophile, wherein: R1 represents a group providing the site for exo-enzyme or acid hydrolysis; R2 represents an intermediate linked to a solid support; R3 represents a carbohydrate, (oligo-)saccharide, (glyco-)peptide, (glyco-)lipid or an organic molecule which is at least one of heterocyclic and aromatic in structure; X represents O, N(H), N(R''), C(O)O, S, C(O)N(H) or C(O)N(R''), R'' being a non-interfering group; and Support represents a solid support.

    专利号:US-10640482-B2
    优先权日:2017-07-21
    标题:Synthesis of cannabinoids
    发明人:LEAHY JAMES WILLIAM; SHULTZ ZACHARY PAUL; LAWRENCE GRANT ALEXANDER
    权利人:UNIV SOUTH FLORIDA
    摘要:Provided are synthesis processes and intermediates for preparing cannabinoids and analogs.

    专利号:US-10975096-B2
    优先权日:2014-06-20
    标题 :Synthesis of polycyclic-carbamoylpyridone compounds
    发明人:CHIU ANNA; ENQUIST JR JOHN; GRIGGS NOLAN; HALE CHRISTOPHER; IKEMOTO NORIHIRO; KEATON KATIE ANN; KRAFT MATT; LAZERWITH SCOTT E; LEEMAN MICHEL; PENG ZHIHUI; SCHRIER KATE; TRINIDAD JONATHAN; VAN HERPT JOCHEM; WALTMAN ANDREW W
    权利人:GILEAD SCIENCES INC
    摘要:Methods of making compounds of Formula I are disclosed:

    专利号:US-2004225153-A1
    优先权日:2003-02-13
    标题 :Synthesis of polyphosphazenes with sulfonimide side groups
    发明人:ALLCOCK HARRY R; HOFMANN MICHAEL A; AMBLER CATHERINE M; MAHER ANDREW E; WOOD RICHARD M; WELNA DANIEL T
    权利人:PENN STATE RES FOUND
    摘要:The invention relates to sulfonimide bearing phenolic compounds and the use of those compounds to produce polyphosphazenes functionalized by one or more of those compounds alone, or in combination with cosubstituents. The invention also relates to blends of sulfonimide functionalized phosphazene polymers with other polymers, membranes formed of the functionalized polymers, and the use of those membranes in devices such as fuel cells.

    专利号:US-5187103-A
    优先权日:1991-01-31
    标题:Colorimetric method and reagent for the assay of lithium in a test sample
    发明人:CZECH BRONISLAW P; CHAPOTEAU EDDY; KUMAR ANAND
    权利人:MILES INC
    摘要:A chromogenic cryptand found to be especially selective in the determination of lithium in blood of the general formula (I): ##STR1## where: n=1 or 2, n R 1 and R 2 , same or different, are hydrogen, lower alkyl, lower alkenyl, or lower alkylidene; and n Q is a chromogenic moiety capable of providing a detectable response upon complexation of said compound with lithium ion and has the structure: ##STR2## wherein: X is CH, C--OH or N; and Z is p-nitrophenylazo, 2,4-dinitrophenylazo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino, bis-(4-dimethylaminophenyl) hydroxymethyl, 3-phenylisothiazolyl-5-azo, thiazolyl-5-azo; or isothiazolyl-5-azo. n A reagent composition and synthesis of a preferred chromogenic cryptand are also disclosed.
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    主要参考文献

    [参考文献]: A Kors, Et Al. Simultaneous Analysis Of Amino Acids And Amines As Their O-Phthalaldehyde-Ethanethiol-9-Fluorenylmethyl Chloroformate Derivatives In Cheese By High-Performance Liquid Chromatography. J Chromatogr A. 2008 Sep 5;1203(2):146-52.
    [参考文献]: Deepak Sail, Et Al. Benzoylated Ethyl 1-Thioglycosides: Direct Preparation From Per-O-Benzoylated Sugars. Carbohydr Res. 2012 Aug 1:357:47-52.
    [参考文献]: Esther Vega, Et Al. Integration Of Advanced Oxidation Processes At Mild Conditions In Wet Scrubbers For Odourous Sulphur Compounds Treatment. Chemosphere. 2014 Aug:109:113-9.
    [参考文献]: J Hernández, Et Al. Startup And Long-Term Performance Of Biotrickling Filters Packed With Polyurethane Foam And Poplar Wood Chips Treating A Mixture Of Ethylmercaptan, H2S, And Nh3. J Air Waste Manag Assoc. 2013 Apr;63(4):462-71.
    [参考文献]: Kinta M Serve, Et Al. Validation Of An Isocratic Hplc Method To Detect 2-Fluoro-Beta-Alanine For The Analysis Of Dihydropyrimidine Dehydrogenase Activity. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Jul 1;878(21):1889-92.

    合成参考文献


    摘要:Baird, M. S., Science of Synthesis, (2010) 47, 1114.
    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 403.
    摘要:Witt, D., Science of Synthesis Knowledge Updates, (2011) 3, 334.
    摘要:Witt, D., Science of Synthesis Knowledge Updates, (2011) 3, 332.
    摘要:Witt, D., Science of Synthesis Knowledge Updates, (2011) 3, 331.
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