专利号:US-5247099-A 优先权日:1989-08-17 标题:Process for synthesis of 7-hydroxy coumarins having substitutions in the 4-position 发明人:CELEBUSKI JOSEPH E 权利人:ABBOTT LAB 摘要:A process for synthesis of a compound of the formula: said process comprising the steps of (a) reacting 4-bromomethyl-7-methoxy coumarin with a malonic ester under conditions sufficient to achieve condensation of the ester to give the monoalkylated (2-bis(carbalkoxy)-2-R1-1-ethyl) derivative; (b) removing one of the carbalkoxy groups from the product of step (a); (c) demethylation of the product of step (b) to give the 7-hydroxycoumarin compound; and (d) chemically modifying the remaining ester to yield a desired R2.
专利号:US-6492136-B1 优先权日:1995-12-07 标题 :Solid phase organic synthesis 发明人:FLITSCH SABINE LAHJA; TURNER NICHOLAS JOHN 权利人:GENZYME LTD 摘要:A method of synthesis of a material corresponding to the general formula:characterized in that it comprises a material corresponding to the following general formula:being cleaved as indicated enzymatically or non-enzymatically using acid catalysis in the presence of a nucleophile, wherein: R1 represents a group providing the site for exo-enzyme or acid hydrolysis; R2 represents an intermediate linked to a solid support; R3 represents a carbohydrate, (oligo-)saccharide, (glyco-)peptide, (glyco-)lipid or an organic molecule which is at least one of heterocyclic and aromatic in structure; X represents O, N(H), N(R''), C(O)O, S, C(O)N(H) or C(O)N(R''), R'' being a non-interfering group; and Support represents a solid support.
专利号:US-10640482-B2 优先权日:2017-07-21 标题:Synthesis of cannabinoids 发明人:LEAHY JAMES WILLIAM; SHULTZ ZACHARY PAUL; LAWRENCE GRANT ALEXANDER 权利人:UNIV SOUTH FLORIDA 摘要:Provided are synthesis processes and intermediates for preparing cannabinoids and analogs.
专利号:US-10975096-B2 优先权日:2014-06-20 标题 :Synthesis of polycyclic-carbamoylpyridone compounds 发明人:CHIU ANNA; ENQUIST JR JOHN; GRIGGS NOLAN; HALE CHRISTOPHER; IKEMOTO NORIHIRO; KEATON KATIE ANN; KRAFT MATT; LAZERWITH SCOTT E; LEEMAN MICHEL; PENG ZHIHUI; SCHRIER KATE; TRINIDAD JONATHAN; VAN HERPT JOCHEM; WALTMAN ANDREW W 权利人:GILEAD SCIENCES INC 摘要:Methods of making compounds of Formula I are disclosed:
专利号:US-2004225153-A1 优先权日:2003-02-13 标题 :Synthesis of polyphosphazenes with sulfonimide side groups 发明人:ALLCOCK HARRY R; HOFMANN MICHAEL A; AMBLER CATHERINE M; MAHER ANDREW E; WOOD RICHARD M; WELNA DANIEL T 权利人:PENN STATE RES FOUND 摘要:The invention relates to sulfonimide bearing phenolic compounds and the use of those compounds to produce polyphosphazenes functionalized by one or more of those compounds alone, or in combination with cosubstituents. The invention also relates to blends of sulfonimide functionalized phosphazene polymers with other polymers, membranes formed of the functionalized polymers, and the use of those membranes in devices such as fuel cells.
专利号:US-5187103-A 优先权日:1991-01-31 标题:Colorimetric method and reagent for the assay of lithium in a test sample 发明人:CZECH BRONISLAW P; CHAPOTEAU EDDY; KUMAR ANAND 权利人:MILES INC 摘要:A chromogenic cryptand found to be especially selective in the determination of lithium in blood of the general formula (I): ##STR1## where: n=1 or 2, n R 1 and R 2 , same or different, are hydrogen, lower alkyl, lower alkenyl, or lower alkylidene; and n Q is a chromogenic moiety capable of providing a detectable response upon complexation of said compound with lithium ion and has the structure: ##STR2## wherein: X is CH, C--OH or N; and Z is p-nitrophenylazo, 2,4-dinitrophenylazo, 2,4,6-trinitrophenylazo, p-nitrostyryl, p-benzoquinonemonoimino, bis-(4-dimethylaminophenyl) hydroxymethyl, 3-phenylisothiazolyl-5-azo, thiazolyl-5-azo; or isothiazolyl-5-azo. n A reagent composition and synthesis of a preferred chromogenic cryptand are also disclosed.
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合成参考文献
摘要:Baird, M. S., Science of Synthesis, (2010) 47, 1114. 摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 403. 摘要:Witt, D., Science of Synthesis Knowledge Updates, (2011) 3, 334. 摘要:Witt, D., Science of Synthesis Knowledge Updates, (2011) 3, 332. 摘要:Witt, D., Science of Synthesis Knowledge Updates, (2011) 3, 331.