CAS: 82572-04-1; (R)-1-(Naphthalen-1-yl)Ethanamine Hydrochloride

• 英文名称(R)-1-(Naphthalen-1-yl)Ethanamine Hydrochloride
• 中文名称(R)-(+)-1-(1-萘基)乙胺盐酸盐
• IUPAC名称(R)-1-(naphthalen-1-yl)ethan-1-amine hydrochloride
• 其它别名1-Naphthalenemethanamine,a-methyl-, hydr°Chloride, (R)-; 1-Naphthalenemethanamine, a-methyl-, hydr°Chloride, (aR)- (9CI); (R)-1-(1-Naphthyl)ethylamine hydr°Chloride
• CAS编号82572-04-1
• MFCD编号:MFCD07369798
• EINECS号:617-358-4
• 分子式:C12H14ClN
• 分子量:207.7
• 产品CID: 1816278
• 产品分类有机原料 → 氨基化合物 → 无环单胺、多胺及其衍生物和盐

• 相似结构搜索
• InChIKey: ZTNKTVBJMXQOBQ-SBSPUUFOSA-N
• InChI=1/C12H13N.ClH/c1-9(13)11-8-4-6-10-5-2-3-7-12(10)11;/h2-9H,13H2,1H3;1H/t9-;/s3…
• 计算化学: 氢键受体数1.0氢键供体数2.0可旋转键数1.0

物理性质

• 熔点253-257 °C(文献)
• 沸点253-257°C(文献)
• 闪点155.7 °C
• PSA:26.02
• LogP:4.3618
• 蒸汽压9.54E-05 mmHg at 25 °C
• 外观形态固体
• 储存条件密封, 常温干燥保存

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别急性毒性 类别4(经口)
  特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  水生急性毒性 类别1
• 警示词Warning(警告)
• 危险描述H302 |吞咽有害.
  H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H400 |对水生生物毒性极大.
• 防范说明P261-P273-P305+P351+P338
• UN编号UN 3077 9 / PGIII
• 危险品标志Xn,N
• 安全声明26-60-61
• 危险类别码22-36/37/38-50
• WGK Germany2

欧盟法规

上下游产品

合成工艺路线路线简述

• 3886-70-2 + 611-71-2 = 82572-04-1
  反应条件:1.1 Reagents: Ammonia Solvents: Toluene,Water; Rt1.2 Reagents: Hydrochloric Acid Solvents: Isopropanol,Ethyl Acetate; Ph 3 - 4,Rt; Rt -> 10 °C; 40 - 50 Min,10 - 15 °C
  标题:Efficient Synthesis And Practical Resolution Of 1-(Naphthalen-1-Yl)Ethanamine,A Key Intermediate For Cinacalcet
  作者:Mathad,Vijayavitthal T.; Et Al
  参考文献:Synthetic Communications 日期:2011 卷标:41(3) 页码:341-346]
  
  = 82572-04-1
  反应条件:1.1 Reagents: Magnesium Solvents: Methanol; Rt1.2 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; 0 °C; 10 Min,Rt1.3 Reagents: Sodium Carbonate Solvents: Water; Rt
  标题:Enantioconvergent Cu-Catalyzed Radical C-N Coupling Of Racemic Secondary Alkyl Halides To Access α-Chiral Primary Amines
  作者:Zhang,Yu-Feng; Et Al
  参考文献:Journal Of The American Chemical Society 日期:2021 卷标:143(37) 页码:15413-15419]
  
  1956-40-7 + 1079-66-9 = 82572-04-1
  反应条件:1.1 Catalysts: Triethylamine2.1 Reagents: Lithium Aluminum Hydride Catalysts: Quinine3.1 Reagents: Hydrochloric Acid
  标题:A Study Of The Synthesis Of Optically Active Amines From Prochiral N-Phosphinylimines
  作者:Krzyzanowska,B.; Et Al
  参考文献:Synthesis 日期:1982 卷标:(4) 页码:270-3]
  
  941-98-0 = 82572-04-1
  反应条件:1.1 Reagents: Sodium Hydroxide,Hydroxyamine Hydrochloride Solvents: Methanol,Water; Ph 6.0 - 6.5,25 - 35 °C; 2 - 3 H,Rt1.2 Reagents: Water; 3 - 4 H,25 - 35 °C2.1 Reagents: Hydrogen,Ammonia Catalysts: Nickel Solvents: Methanol,Water; 3 - 4 H,3.5 - 4.0 Kg/cm2,58 - 62 °C2.2 Reagents: Hydrochloric Acid Solvents: Dichloromethane,Water; 15 - 20 Min,Ph 1 - 2,Rt2.3 Reagents: Ammonia Solvents: Water; Ph 10 - 112.4 Solvents: Ethanol; 10 Min; 45 Min,60 - 65 °C; 65 °C -> 25 °C; 2 - 3 H,25 - 35 °C3.1 Reagents: Ammonia Solvents: Toluene,Water; Rt3.2 Reagents: Hydrochloric Acid Solvents: Isopropanol,Ethyl Acetate; Ph 3 - 4,Rt; Rt -> 10 °C; 40 - 50 Min,10 - 15 °C
  标题:Efficient Synthesis And Practical Resolution Of 1-(Naphthalen-1-Yl)Ethanamine,A Key Intermediate For Cinacalcet
  作者:Mathad,Vijayavitthal T.; Et Al
  参考文献:Synthetic Communications 日期:2011 卷标:41(3) 页码:341-346]
  
  344248-49-3 = 82572-04-1
  反应条件:1.1 Reagents: Hydrochloric Acid
  标题:A Study Of The Synthesis Of Optically Active Amines From Prochiral N-Phosphinylimines
  作者:Krzyzanowska,B.; Et Al
  参考文献:Synthesis 日期:1982 卷标:(4) 页码:270-3]
  
  611-71-2 + 1956-40-7 = 82572-04-1
  反应条件:1.1 Reagents: Hydrogen,Ammonia Catalysts: Nickel Solvents: Methanol,Water; 3 - 4 H,3.5 - 4.0 Kg/cm2,58 - 62 °C1.2 Reagents: Hydrochloric Acid Solvents: Dichloromethane,Water; 15 - 20 Min,Ph 1 - 2,Rt1.3 Reagents: Ammonia Solvents: Water; Ph 10 - 111.4 Solvents: Ethanol; 10 Min; 45 Min,60 - 65 °C; 65 °C -> 25 °C; 2 - 3 H,25 - 35 °C2.1 Reagents: Ammonia Solvents: Toluene,Water; Rt2.2 Reagents: Hydrochloric Acid Solvents: Isopropanol,Ethyl Acetate; Ph 3 - 4,Rt; Rt -> 10 °C; 40 - 50 Min,10 - 15 °C
  标题:Efficient Synthesis And Practical Resolution Of 1-(Naphthalen-1-Yl)Ethanamine,A Key Intermediate For Cinacalcet
  作者:Mathad,Vijayavitthal T.; Et Al
  参考文献:Synthetic Communications 日期:2011 卷标:41(3) 页码:341-346]
  
  73765-07-8 + 22731-83-5 = 82572-04-1
  反应条件:1.1 Reagents: Cesium Carbonate Catalysts: (2-Thiophenecarboxylato-Ko2,Ks1)Copper,2-[bis[3,3′′,5,5′′-Tetrakis(1,1-Dimethylethyl)[1,1′:3′,1′′-Terphenyl]-5′-Yl]Phos... Solvents: Diethyl Ether; 72 H,Rt2.1 Reagents: Magnesium Solvents: Methanol; Rt2.2 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; 0 °C; 10 Min,Rt2.3 Reagents: Sodium Carbonate Solvents: Water; Rt
  标题:Enantioconvergent Cu-Catalyzed Radical C-N Coupling Of Racemic Secondary Alkyl Halides To Access α-Chiral Primary Amines
  作者:Zhang,Yu-Feng; Et Al
  参考文献:Journal Of The American Chemical Society 日期:2021 卷标:143(37) 页码:15413-15419]
  
  82572-09-6 = 82572-04-1
  反应条件:1.1 Reagents: Lithium Aluminum Hydride Catalysts: Quinine2.1 Reagents: Hydrochloric Acid
  标题:A Study Of The Synthesis Of Optically Active Amines From Prochiral N-Phosphinylimines
  作者:Krzyzanowska,B.; Et Al
  参考文献:Synthesis 日期:1982 卷标:(4) 页码:270-3]
  
  945-51-7 = 82572-04-1
  反应条件:1.1 Reagents: Ammonium Carbamate,Iodobenzene Diacetate Solvents: Methanol; 0 °C -> Rt; Overnight,Rt2.1 Reagents: Cesium Carbonate Catalysts: (2-Thiophenecarboxylato-Ko2,Ks1)Copper,2-[bis[3,3′′,5,5′′-Tetrakis(1,1-Dimethylethyl)[1,1′:3′,1′′-Terphenyl]-5′-Yl]Phos... Solvents: Diethyl Ether; 72 H,Rt3.1 Reagents: Magnesium Solvents: Methanol; Rt3.2 Reagents: Hydrochloric Acid Solvents: 1,4-Dioxane; 0 °C; 10 Min,Rt3.3 Reagents: Sodium Carbonate Solvents: Water; Rt
  标题:Enantioconvergent Cu-Catalyzed Radical C-N Coupling Of Racemic Secondary Alkyl Halides To Access α-Chiral Primary Amines
  作者:Zhang,Yu-Feng; Et Al
  参考文献:Journal Of The American Chemical Society 日期:2021 卷标:143(37) 页码:15413-15419]
  
  40280-57-7 = 82572-04-1 + 51600-24-9
  反应条件:1.1 Reagents: N-Butyl-N-[(4S,14S)-4,14-Dimethyl-3,6,9,12,15-Pentaoxa-21-Azabicyclo[15.3.1]Hene... (Reaction Product With Silica Gel)
  标题:Preparation Of Pyridino-Crown Ether-Based New Chiral Stationary Phases And Preliminary Studies On Their Enantiomer Separating Ability For Chiral Protonated Primary Aralkylamines
  作者:Kupai,Jozsef; Et Al
  参考文献:Tetrahedron: Asymmetry 日期:2012 卷标:23(6-7) 页码:415-427

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  2902902000-精萘
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