CAS: 933-52-8; Tetramethylcyclobutane-1,3-Dione

• 英文名称Tetramethylcyclobutane-1,3-Dione
• 中文名称四甲基-1,3-二酮
• IUPAC名称2,2,4,4-tetramethylcyclobutane-1,3-dione
• 其它别名四甲基环丁烷-1,3-二酮; Tetramethylcyclobuta-1,3-Dione
• CAS编号933-52-8
• MFCD编号:MFCD00001331
• EINECS号:213-269-6
• FDA UNII编号:RT4AQ22KS4
• 分子式:C8H12O2
• 分子量:140.18
• 产品CID: 1971674
• 产品分类有机原料→分子砌块→脂肪环类化合物→环丁烷类化合物

• 相似结构搜索
• 产品信息参考;;
• InChIKey: RGCDVHNITQEYPO-UHFFFAOYSA-N
• InChI=1S/C8H12O2/c1-7(2)5(9)8(3,4)6(7)10/h1-4H3…
• 计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数0.0

相似化合物

物理性质

• 熔点114-116 °C
• 沸点95-159 °C at 750 mmHg
• 闪点74.3±17.4 °C
• 密度1.0±0.1 g/cm3
• PSA:34.14
• LogP:1.1906
• 折射率1.443
• 蒸汽压0.2±0.4 mmHg at 25°C
• 溶解性It Is Soluble In Chloroform.
• 敏感性常温常压下稳定，避免氧化物接触
• 外观形态白色至几乎白色粉末至晶体
• 储存条件密封, 常温干燥保存
• 产品应用该化合物用于制造其他化学品以及化学和有机中间体.

MSDS等安全信息

• GHS符号GHS07
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2A
• 警示词Warning
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P264-P270-P280-P302+P352-P330-P362+P364-P501
• UN编号NONH for all modes of transport
• 安全声明24/25
• 危险类别码A tumorigen; [RTECS] May cause irritation; [MSDSonline]
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 3010-96-6 = 933-52-8
  反应条件:1.1 Reagents: Dimethyl Sulfoxide,Cobalt Chloride (Cocl2)
  标题:Oxidation Of Alcohols To Carbonyl Compounds Via Alkoxysulfonium Ylides: The Moffat,Swern,And Related Oxidations
  作者:Tidwell,Thomas T.
  参考文献:Organic Reactions (Hoboken 日期:1990 卷标:39]
  
  79-30-1 = 933-52-8
  反应条件:1.1 Reagents: Triethylamine Solvents: Tert-Butyl Methyl Ether
  标题:Preparation Of 2,2,4,4-Tetrasubstituted 1,3,5-Cyclohexanetriones From Cyclobutan-1,3-Diones.
  参考文献:World Intellectual Property Organization]
  
  10181-59-6 = 933-52-8
  反应条件:1.1 Reagents: (Trifluoromethyl)Trimethylsilane Solvents: Tetrahydrofuran; 2 H,Rt1.2 Reagents: Tetrabutylammonium Fluoride Solvents: Tetrahydrofuran; 3 H,0 - 5 °C
  标题:Studies On Reactions Of Thioketones With Trimethyl(Trifluoromethyl)Silane Catalyzed By Fluoride Ions
  作者:Mloston,Grzegorz; Prakash,G. K. Surya; Olah,George A.; Heimgartner,Heinz
  参考文献:Helvetica Chimica Acta 日期:2002 卷标:85(6) 页码:1644-1658]
  
  15848-07-4 + 10181-59-6 = 933-52-8 + 170963-67-4
  反应条件:1.1 Solvents: Chloroform; Rt
  标题:2,2,4,4-Tetramethylcyclobutane-1-One-3-Thione
  作者:Heimgartner,Heinz; Mloston,Grzegorz
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2004 卷标:1 页码:1-6]
  
  598-26-5 = 933-52-8
  反应条件:1.1 2 - 24 H,75 °C
  标题:Method And Device For Preparation Of Compounds Using Isobutyric Acid And Acetic Anhydride
  参考文献:China]
  
  598-26-5 = 933-52-8
  反应条件:1.1 25 °C
  标题:Preparation Of Tetramethyl Cyclobutanedione
  参考文献:China]
  
  97-72-3 = 933-52-8
  反应条件:1.1 Catalysts: Alumina,Lanthanum,Silica; 400 °C
  标题:Preparation Method Of 2,2,4,4-Tetramethyl-1,3-Cyclobutanediol
  参考文献:Korea]
  
  97-72-3 = 933-52-8
  反应条件:1.1 30 Kpa,480 °C1.2 Solvents: Dimethyl Adipate,1,3-Dimethyl 1,3-Cyclohexanedicarboxylate; 80 Min,120 °C
  标题:Method For Synthesizing 2,2,4,4-Tetramethyl-1,3-Cyclobutanedione
  参考文献:China]
  
  598-26-5 = 933-52-8 [标题:Reaction Conditions
  标题:Ketene Cycloadditions
  作者:Hyatt,John A.; Raynolds,Peter W.
  参考文献:Organic Reactions (Hoboken 日期:1994 卷标:45]
  
  23604-61-7 = 933-52-8
  反应条件:1.1 Catalysts: Trifluoroacetic Acid Solvents: Tetrahydrofuran,Water
  标题:1,3-Dipolar Cycloadditions. Part 122; Cycloadditions Of "Thiocarbonyl Ylides" With Tetracyanoethylene (=ethenetetracarbonitrile): Interception Of Intermediates
  作者:Huisgen,Rolf; Mloston,Grzegorz; Langhals,Elke
  参考文献:Helvetica Chimica Acta 日期:2001 卷标:84(6) 页码:1805-1820]
  
  79-30-1 = 933-52-8
  反应条件:1.1 Reagents: Triethylamine,Zinc Solvents: Ethyl Acetate; 30 Min,40 °C; 20 H,40 °C -> 68 °C
  标题:Method For Producing 2,2,4,4-Tetramethyl-1,3-Cyclobutanediol Using Triethylamine And Metal Powder
  参考文献:China]
  
  598-26-5 = 933-52-8
  反应条件:1.1 6 H,120 °C
  标题:Preparation And Application Of Ketene Compounds
  参考文献:China]
  
  598-26-5 = 933-52-8
  反应条件:1.1 Reagents: Dodecane Solvents: Ethanol; 60 Min,0.5 Mpa,120 °C
  标题:Preparation Method Of 2,2,4,4-Tetramethylcyclobutane-1,3-Dione And 2,2,4,4-Tetramethylcyclobutane-1,3-Diol From Dimethylketene By Using Low-Boiling Point Solvent
  参考文献:China]
  
  598-26-5 = 933-52-8
  反应条件:1.1 Solvents: Isobutyl Isobutyrate; 48 H,25 °C
  标题:Synthetic Preparation Of 2,2,4,4-Tetramethyl-1,3-Cyclobutanedione
  参考文献:China]
  
  79-31-2 = 933-52-8
  反应条件:1.1 400 - 600 °C
  标题:Preparation Method Of 2,2,4,4-Tetramethyl-1,3-Cyclobutanediol
  参考文献:Korea]
  
  10181-56-3 = 933-52-8
  反应条件:1.1 Reagents: Oxygen Solvents: Isopropanol
  标题:2,2,4,4-Tetramethylcyclobutane-1,3-Dithione
  作者:Heimgartner,Heinz; Mloston,Grzegorz
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2004 卷标:1 页码:1-5]
  
  598-26-5 = 933-52-8
  反应条件:1.1 Solvents: Ethyl Acetate; Rt -> 70 °C; 2 H,0.02 Mpa,70 °C
  标题:Process For Preparation Of 2-Amino-2-Methyl-1-Propionate
  参考文献:China]
  
  79-30-1 = 933-52-8
  反应条件:1.1 Reagents: Triethylamine Solvents: Propyl Ether; 15 H,Reflux
  标题:Method For Preparation Of 2,2,4,4-Tetramethyl-1,3-Cyclobutanediol
  参考文献:China

海关参考信息

• 2912110000-甲醛
  2912120000-乙醛
  2914110000-丙酮
  2914120000-丁酮
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