CAS: 943-14-6; 2-Bromo-5-Nitrobenzoic Acid

该化合物是一种溴化和硝酸芳烃式的碳oxylic酸,主要用作有机合成和制药研究的中间体,其主要结构特征--一个碳箱酸组,溴替代组和硝基组,分别位于2和5个位置--使其成为构建复杂分子的多功能建筑块.溴组通过交叉反应促进进一步发挥作用,而硝基化合物组则可以减少到一种矿,以获得其他衍生物.该化合物对于发展农业化学,染料和活性药物成分(API)特别有价值,因为精确的替代模式至关重要.其高纯度和稳定性确保了合成应用的可靠性能.

结构式图片

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ECHA物质C&L通报REACH预注册

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CAS号108100-28-3 7-METHYL-2-NITR... | CAS号586-78-7 对溴硝基苯 | CAS号100-01-6 对硝基苯胺 | CAS号616-79-5 2-氨基-5-硝基苯甲酸 | CAS号4036-83-3 2-吗啉-5-硝基苯甲酸 | CAS号20246-81-5 4,4'-二硝基-1,1'-联... | CAS号23305-76-2 4,4'-二硝基- [1,1'... | CAS号84459-32-5 2-溴-5-硝基苯甲醛 | CAS号96-97-9 5-硝基水杨酸 | CAS号6942-36-5 2-溴-5-硝基苯甲酸甲酯

合成工艺路线路线简述

  • 合成目标产物 2-Bromo-5-Nitrobenzoic Acid 主要起始原料 2-Bromobenzoic Acid
  • 88-65-3 = 943-14-6
    反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; Cooled; 1 H,< 5 °C
    标题:Donor-Acceptor Biaryl Lactones: Ph Induced Molecular Switches With Intramolecular Charge Transfer Modulation
    作者:Carlson,Erik J.; Riel,Asia Marie S.; Dahl,Bart J.
    参考文献:Tetrahedron Letters 日期:2012 卷标:53(46) 页码:6245-6249]

    88-65-3 = 943-14-6
    反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; < 5 °C; 1 H,< 5 °C1.2 Reagents: Water; Cooled
    标题:Preparation Of Pyrrolidinylchromenones As Inhibitors Of Cyclin-Dependent Kinases
    参考文献:United States]

    = 943-14-6 [标题:Reaction Conditions
    标题:Benzamide Derivatives With Pharmacological Properties
    参考文献:Spain]

    88-65-3 = 943-14-6
    反应条件:1.1 Reagents: Sulfuric Acid,Nitric Acid Solvents: Water; < 5 °C; 1 H,< 5 °C
    标题:Preparation Of Pyrrolidinylchromenones As Inhibitors Of Cyclin-Dependent Kinases.
    参考文献:World Intellectual Property Organization]

    = 943-14-6
    反应条件:1.1 Reagents: Sulfuric Acid,Permanganic Acid (Hmno4),Potassium Salt (1:1)
    标题:Synthesis Of Lysergic Acid. I. Derivatives Of Indole
    作者:Barltrop,J. A.; Taylor,D. A. H.
    参考文献:Journal Of The Chemical Society 日期:1954 卷标:3399 页码:3399-3403]

    121-92-6 = 943-14-6
    反应条件:1.1 Reagents: Bromine,Potassium Bromide
    标题:Syntheses Of Naphthoic Mercury Compounds And Their Reaction With Nucleophilic Reagents
    作者:Takahashi,Teruo
    参考文献:Yakugaku Zasshi 日期:1978 卷标:98(3) 页码:358-65]

    84459-32-5 = 943-14-6
    反应条件:1.1 Reagents: Sodium Bicarbonate,Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Water; Overnight,Rt
    标题:Tandem Copper Catalyzed Regioselective N-Arylation-Amidation: Synthesis Of Angularly Fused Dihydroimidazoquinazolinones And The Anticancer Agent Tic10/onc201
    作者:Honnanayakanavar,Jyoti M.; Nanubolu,Jagadeesh Babu; Suresh,Surisetti
    参考文献:Organic & Biomolecular Chemistry 日期:2021 卷标:19(39) 页码:8497-8501]

    = 943-14-6 [标题:Reaction Conditions
    标题:The Discovery Of Novel Small Molecule Allosteric Activators Of Aldehyde Dehydrogenase 2
    作者:Tian,Wei; Guo,Jiapeng; Zhang,Qingsen; Fang,Shaoyu; Zhou,Ruolan; Et Al
    参考文献:European Journal Of Medicinal Chemistry 日期:2021 卷标:212]

    = 943-14-6 [标题:Reaction Conditions
    标题:Method For Preparing 5-Amino-2-Bromobenzoic Acid
    参考文献:China
2-溴苯甲酸 反应生成 2-溴-5-硝基苯甲酸
参考文献:Rhalis,Justus Liebigs Annalen Der Chemie,1879,Vol. 198,P. 103
标题:Rhalis,Justus Liebigs Annalen Der Chemie,1879,Vol. 198,P. 103

海关参考信息

专利信息


专利号:US-7943723-B2
优先权日:2006-12-21
标 题:Process for the synthesis of ethers of aromatic acids
发明人:RITTER JOACHIM C
权利人:DU PONT
摘要:The inventions disclosed herein include processes for the preparation of an ether of an aromatic acid, processes for the preparation of products into which such an ether can be converted, the use of such processes, and the products obtained and obtainable by such processes. A key feature of the processes described is the use of a solvent comprising an alcohol ROH and an alcoholate RO − M + .

专利号:US-8207374-B2
优先权日:2006-12-21
标 题:Process for the synthesis of ethers of aromatic acids
发明人:RITTER JOACHIM C
权利人:RITTER JOACHIM C; DU PONT
摘要:Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diketone ligand that coordinates to copper.

专利号:US-2011060118-A1
优先权日:2009-09-02
标 题:Process for the synthesis of fluorinated ethers of aromatic acids
发明人:RITTER JOACHIM C; MOLOY KENNETH GENE; POLLINO JOEL M; MAHAJAN DU SURBHI
权利人:DU PONT
摘要:Fluorinated ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a Schiff base ligand that coordinates to copper. The fluorinated ethers of aromatic acids made using the process described herein can be applied to, e.g., fibers, yarns, carpets, garments, films, molded parts, paper and cardboard, stone, and tile to impart soil, water and oil resistance. By incorporating the fluorinated ethers of aromatic acids, or diesters thereof, into polymer backbones, more lasting soil, water and oil resistance, as well as improved flame retardance, can be achieved.

专利号:US-7985825-B2
优先权日:2006-12-21
标 题 :Process for the synthesis of ethers of aromatic acids
发明人:RITTER JOACHIM C
权利人:DU PONT
摘要:Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a halogenated aromatic acid such as is described by the structure of Formula II n nwherein each X is independently Cl, Br or I; the reaction mixture further comprising;n (i) a polar protic solvent, a polar aprotic solvent or an alcoholic solvent containing the alcoholate RO-M+ (wherein M is Na or K), wherein the polar protic solvent, polar aprotic solvent or alcoholic solvent is either ROH or is a solvent that is less acidic than ROH; (ii) a copper (I) or copper (II) source; and (iii) an amino acid ligand that coordinates to copper, wherein the ligand comprises an amino acid in which the amine nitrogen and the carboxyl carbon are separated by no more than two carbon atoms.

专利号:US-2011060117-A1
优先权日:2009-09-02
标题:Process for the synthesis of fluorinated ethers of aromatic acids
发明人:RITTER JOACHIM C; MOLOY KENNETH GENE; POLLINO JOEL M; MAHAJAN DU SURBHI
权利人:DU PONT
摘要:Fluorinated ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diamine ligand that coordinates to copper. The fluorinated ethers of aromatic acids made using the process described herein can be applied to, e.g., fibers, yarns, carpets, garments, films, molded parts, paper and cardboard, stone, and tile to impart soil, water and oil resistance. By incorporating the fluorinated ethers of aromatic acids, or diesters thereof, into polymer backbones, more lasting soil, water and oil resistance, as well as improved flame retardance, can be achieved.

专利号:US-2011060161-A1
优先权日:2009-09-02
标题 :Process for the synthesis of fluorinated ethers of aromatic acids
发明人:RITTER JOACHIM C; MOLOY KENNETH GENE; POLLINO JOEL M; DU SURBHI MAHAJAN
权利人:DU PONT
摘要:Fluorinated ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diketone ligand that coordinates to copper. The fluorinated ethers of aromatic acids made using the process described herein can be applied to, e.g., fibers, yarns, carpets, garments, films, molded parts, paper and cardboard, stone, and tile to impart soil, water and oil resistance. By incorporating the fluorinated ethers of aromatic acids, or diesters thereof, into polymer backbones, more lasting soil, water and oil resistance, as well as improved flame retardance, can be achieved.
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合成参考文献


参考文献:10.1021/ja710862u
摘要:Bee C, Han SB, Hassan A, Iida H, Krische MJ. Diastereo- and enantioselective hydrogenative aldol coupling of vinyl ketones: design of effective monodentate TADDOL-like phosphonite ligands. J Am Chem Soc. 2008 Mar 05;130(9):2746–7.
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