专利号:US-2006009479-A1 优先权日:2004-07-09 标 题 :Process for the synthesis of hydromorphone 发明人:BAILEY TIMOTHY S; GEE PAUL S; REZAIE ROBERT 权利人:BAILEY TIMOTHY S; GEE PAUL S; REZAIE ROBERT 摘要:There is described a method for converting oripavine to hydromorphone or a physiologically acceptable salt thereof such as hydromorphone hydrochloride involving generation of 8,14-dihydrooripavine utilising diimine.
专利号:US-5081138-A 优先权日:1986-12-17 标题:3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith 发明人:GILLARD JOHN W; MORTON HOWARD E; FORTIN REJEAN; GUINDON YVAN 权利人:MERCK FROSST CANADA INC 摘要:Compounds having the formula: are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
专利号:US-2005240034-A1 优先权日:2002-05-07 标 题 :Artemisinin-based peroxide compounds as broad spectrum anti-infective agents 发明人:AVERY MITCHELL; MURALEEDHARAN KANNOTH M 权利人:AVERY MITCHELL; MURALEEDHARAN KANNOTH M 摘要:Described herein is the synthesis, bioassay results and utility of new C- 9 and C- 10 substituted artemisinin derivatives with easily functionalizable groups attached to the artemisinin skeleton through carbon chain or heteroatoms. Described also is the demonstration of this class of compounds for their broad-spectrum anti-parasitic activity. Certain of these analogs possess noticeable cytotoxicity deliberately focused on treatment of cancerous diseases.
参考标题:The Organocatalytic Synthesis Of Perfluorophenylsulfides Via The Thiolation Of Trimethyl(Perfluorophenyl)Silanes And Thiosulfonates 作者:Jinyun Luo,Muze Lin,Leifang Wu,Zhihua Cai,Lin He,Guangfen Du 摘要:The Organic Superbase T-Bu-P4-Catalyzed Direct Thiolation Of Trimethyl(Perfluorophenyl)Silanes And Thiosulfonates Was Developed. Yields Of Perfluorophenylsulfides Of Up To 97% Under Catalysis Of 5 Mol% T-Bu-P4 Were Achieved. This Method Was Shown To Provide An Efficient Way To Construct The Perfluorophenyl-Sulfur Bond Under Mild Metal-Free Reaction Conditions.
合成参考文献
摘要:Krause, N.; Arisetti, N., Science of Synthesis Knowledge Updates, (2020) 3, 49. 摘要:Nieto, C. T.; Eames, J.; Garrido, N. M., Science of Synthesis Knowledge Updates, (2019) 1, 141. 摘要:Götzinger, A. C.; Müller, T. J. J., Science of Synthesis Knowledge Updates, (2017) 3, 168. 摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 311. 摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2019) 1, 370.