CAS: 15681-89-7; Sodium Borodeuteride (Isotopic)

Carbonyl(η-Cyclohepta-1,4-Diene)(η-Cyclohexa-1,3-Diene)Iron置于一氧化碳体系中,用 Not Given 用作溶剂,化学反应生成硼氘化钠
参考文献:羰基(η-环庚-1,4-二烯)(η-环己-1,3-二烯)铁配合物的制备和异构化
标题:羰基(η-环庚-1,4-二烯)(η-环己-1,3-二烯)铁配合物的制备和异构化
摘要:用水中的na [bh 4 ]还原[fe(c 6 H 8)(c 7 H 9)(co)] +,(i)产生[fe(η-1,3-C6 H 8) (η-1,4-C 7 H ^ 10)-(co)],(II),以非常好的收率连同一些的[fe(η-1,3--C 7 H ^ 10)(co)],(III) .加热时,(II)(以固体或溶液形式)经历异构化为(III)和一些[fe(η-1,3-C6 H 8)(1-σ,3-5-η-C 7 H 10)(co)].在正庚烷中,在40-70oc的温度范围内研究了这一一级反应的动力学,并将结果与相关系统进行了比较.用na [bd 4 ]还原(i)得到单氘代的η-环庚-1,4-二烯配合物.对该络合物的反应和光谱学研究(尤其是1 H和13 C NMR)表明,亲核加成发生在exo-3-位置,并且内氢原子在异构化过程中迁移.也将氰化物离子加到络合物阳离子上的exo-3-位置,产物重排成η-2-取代的-1
Doi:10.1039/dt9760000421

专利信息

专利号:US-12291505-B2
优先权日:2016-07-04
标题 :Methods for the synthesis of deuterated dextromethorphan
发明人：JOHNSON MATT; ZHAO CUNXIANG; MENG WEIHUA; LU ZHIJUN; LI YAN
权利人:AVANIR PHARMACEUTICALS INC
摘要:The application describes methods for making a deuterated dextromethorphan of Formula (I), deuterated dextromethorphan produced by these methods, and pharmaceutically acceptable salts thereof.

专利号:US-2025250234-A1
优先权日:2022-04-12
标 题:Fluoroalcohols as co-solvents for chemical synthesis and methods for producing the same
发明人：COLBY DAVID; ISLAM BAHARUL
权利人:UNIV MISSISSIPPI
摘要:In one aspect, the disclosure relates to a method for the in situ generation of formaldehyde for the hydroxymethylation of difluoroenolates to create 2,2-difluoroethanols having a range of solubilities, acidity, basicity, and other physical properties. The method also allows the production of formaldehyde-d 2 for hydroxy deuteromethylations and constitutes a new synthetic method for 2,2-difluoro-1,1-deuteroethanols. In one aspect, disclosed method is compatible with α,α-difluorobenzyl carbanions generated from the release of trifluoroacetate from electron-deficient aromatic and heteroaromatic rings and can be conducted under mild conditions with high yields. Also disclosed herein are 2,2-difluoroethanols generated by the disclosed method and methods of using the 2,2-difluoroethanols as solvents or co-solvents for organic synthesis, metal catalyzed reactions, asymmetric processes, carbohydrate chemistry, and medicinal chemistry.

专利号:US-2024124402-A1
优先权日:2016-07-04
标 题:Methods for the synthesis of deuterated dextromethorphan

专利号:US-12037420-B2
优先权日:2015-11-05
标题 :Dextran-poly alpha-1,3-glucan graft copolymers and synthesis methods thereof
发明人：BEHABTU NATNAEL; ARTHUR SAMUEL DAVID
权利人:NUTRITION & BIOSCIENCES USA 4 INC; NUTRITION &BIOSCIENCES USA 4 INC
摘要:Compositions are disclosed herein comprising a graft copolymer having (i) a backbone comprising dextran with a molecular weight of at least about 100000 Daltons, and poly alpha-1,3-glucan side chains comprising at least about 95% alpha-1,3-glucosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in absorbent materials.

专利号:US-2024067608-A1
优先权日:2016-07-04
标 题:Methods for the synthesis of deuterated dextromethorphan

专利号:US-2024409557-A1
优先权日:2023-05-09
标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).