CAS: 15761-39-4; (S)-1-(Tert-Butoxycarbonyl)Pyrrolidine-2-Carboxylic Acid

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号147-85-3 脯氨酸 | CAS号69610-40-8 B°C-L-脯氨醇 | CAS号110345-80-7 (S)-1-tert-buty... | CAS号34619-03-9 碳酸二叔丁酯 | CAS号83528-04-5 (S)-N-benzyl-O-... | CAS号59936-29-7 (S)-1-叔-丁基-2-甲基... | CAS号98015-52-2 tert-butyl 1,2,... | CAS号1070-19-5 Carbonazidic ac... | CAS号91237-84-2 (2S)-5-氧代-1,2-吡... | CAS号56502-01-3 B°C-L-beta-高脯氨酸 | CAS号33300-72-0 B°C-乙酰氨基异戊酸 | CAS号3705-27-9 环(甘氨酸-L-脯氨酸)二肽 | CAS号35150-07-3 B°C-L-脯氨酸酰胺 | CAS号70138-72-6 N-B°C-D-脯氨酰胺 | CAS号59936-29-7 (S)-1-叔-丁基-2-甲基... | CAS号91229-91-3 (S)-N-叔丁氧羰基-2-吡... | CAS号51207-66-0 (S)-(+)-1-(2-吡咯... | CAS号37784-17-1 B°C-D-脯氨酸 | CAS号93643-24-4 (S)-1,4-氮杂双环[4....

N-Boc-Proline Tert-Butyl Ester置于碘 水体系中,用 乙腈 用作溶剂,化学反应 5.0H,以92%的收率获得boc-L-脯氨酸
参考文献:使用分子碘作为温和高效的催化剂对叔丁酯在乙腈中的化学选择性水解
标题:使用分子碘作为温和高效的催化剂对叔丁酯在乙腈中的化学选择性水解
摘要:描述了一种使用分子碘作为催化剂水解叔丁酯的简单,温和有效的方法.酸不稳定的保护基团,例如n-B°C,Obn,Oac和双键在反应条件下是相容的.
Doi:10.1016/j.Tetlet.2006.05.011

专利信息

专利号:US-7589170-B1
优先权日:1998-09-25
标题 :Synthesis of cyclic peptides
发明人：SMYTHE MARK LESLIE; MEUTERMANS WIM DENIS FRANS; BOURNE GREGORY THOMAS; MCGEARY ROSS PETER
权利人:UNIV QUEENSLAND
摘要:This invention relates to methods for preparing cyclic peptides and peptidomimetic compounds in solution and bound to solid supports, and to cyclic peptide or peptidomimetic libraries for use in drug screening programs. In particular, the invention relates to a generic strategy for synthesis of cyclic peptides or peptidomimetics that enables the efficient synthesis under mild conditions of a wide variety of desired compounds. Two approaches were evaluated for their improvements in solution and solid phase synthesis of small cyclic peptides: positioning reversible N-amide substituents in the sequence; and applying native ligation chemistry in an intramolecular sense. Systematic investigation of the effects of preorganising peptides prior to cyclisation by using peptide cyclisation auxiliaries, and developing new linkers and peptide cyclisation auxiliaries to aid cyclic peptide synthesis gives surprising improvements in both yields and purity of products compared to the prior art methods. The combination of these technologies provides a powerful generic approach for the solution and solid phase synthesis of small cyclic peptides. The ring contraction and N-amide substitution technology of the invention provide improved methods for the synthesis of cyclic peptides and peptidomimetics. When used in conjunction with linker strategies, this combination provides solid-phase avenues to cyclic peptides and peptidomimetics.

专利号:WO-9312076-A1
优先权日:1991-12-13
标题:Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS ROY
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:US-5367072-A
优先权日:1990-12-14
标 题 :Reagents for automated synthesis of peptide analogs
发明人：WEBB THOMAS R
权利人:CORVAS INT INC
摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

专利号:EP-1246837-B1
优先权日:2000-01-11
标 题:Oligomers of nonpeptide restricted mimetics of dipeptides or tripeptides and the use thereof in the synthesis of synthetic proteins and polypeptides
发明人：AMBLARD MURIEL; MARTINEZ JEAN; BERGE GILBERT
权利人:CENTRE NAT RECH SCIENT
摘要:The invention relates to nonpeptide oligomers of amino acids. The oligomers comprise -(NR'-A-CO)-O- units which represent a nonpeptide, restricted-mimetic inducer of the beta turn in a dipeptide or tripeptide fragment. Said oligomers may be produced by peptide synthesis techniques, whether in solution or in the solid phase, and can be used in the synthesis of synthetic proteins or polypeptides, in which the peptide fragment(s) (is) are identical to those of the corresponding natural protein or polypeptide and whose structural fragment(s) comprise(s) a fragment of an oligomer according to the invention.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2018265547-A1
优先权日:2014-07-18
标 题 :Z-selective olefin metathesis of peptides
发明人：MANGOLD SHANE L; GRUBBS ROBERT H
权利人:CALIFORNIA INST OF TECHN
摘要:The invention relates generally to the synthesis of modified amino acids and modified peptides in the presence of cyclometalated catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.