CAS: 247068-85-5; (S)-2-Amino-4-Methyl-1-((R)-2-Methyloxiran-2-yl)Pentan-1-One 2,2,2-Trifluoroacetate

相似化合物

1528769-14-3 2803375-51-9 2436762-87-5

Boc-D-亮氨酸置于2-溴丙烯,双氧水,Magnesium,溶剂黄146,1,8-二氮杂双环[5.4.0]十一碳-7-烯,N,N'-羰基二咪唑体系中,用 四氢呋喃,二氯甲烷,甲基叔丁基醚,水,乙腈 用作溶剂,化学反应 20.0H,反应生成(S)-2-氨基-4-甲基-1-((R)-2-甲基环氧乙烷-2-基)-1-戊酮三氟乙酸盐
参考文献: Synthesis Of (S)-2-Amino-4-Methyl-1-((R)-2-Methyloxirane-2-yl)-Pentan-1-One And Pharmaceutically Acceptable Salts Thereof[fr] Synthèse De (S)-2-Amino-4-Méthyl-1-((R)-2-Méthyloxirane-2-yl)-Pentan-1-One Et De Ses Sels Pharmaceutiquement Acceptables
标题: Synthesis Of (S)-2-Amino-4-Methyl-1-((R)-2-Methyloxirane-2-yl)-Pentan-1-One And Pharmaceutically Acceptable Salts Thereof[fr] Synthèse De (S)-2-Amino-4-Méthyl-1-((R)-2-Méthyloxirane-2-yl)-Pentan-1-One Et De Ses Sels Pharmaceutiquement Acceptables
摘要:本发明提供了制备化合物(5)及其药学上可接受的盐的新方法,该化合物具有特定结构.化合物(5)或其药学上可接受的盐是合成卡非佐米的重要中间体.本发明还提供了制备一种有用的锰催化剂的方法,该催化剂可用于本发明中的环氧化步骤.

专利信息

专利号:US-11708341-B2
优先权日:2016-08-05
标题:Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof
发明人：Beaver Matthew; CUI SHENG; SHI XIANGQING
权利人:AMGEN INC
摘要:The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure n nCompound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.

专利号:EP-3494108-B1
优先权日:2016-08-05
标 题:Synthesis of (s)-2-amino-4-methyl-1-((r)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof

专利号:JP-7229912-B2
优先权日:2016-08-05
标题:Synthesis of (S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)-pentan-1-one and its pharmaceutically acceptable salts

专利号:EP-3330260-A1
优先权日:2016-12-01
标题:Process for the preparation of an intermediate for the synthesis of i.a. carfilzomib

专利号:JP-2019525945-A
优先权日:2016-08-05
标题:Synthesis of (S) -2-amino-4-methyl-1-((R) -2-methyloxiran-2-yl) -pentan-1-one and pharmaceutically acceptable salts thereof

专利号:US-2021284617-A1
优先权日:2016-08-05
标题:Synthesis of (S)-2-Amino-4-Methyl-((R)-2-Methyloxirane-2-Yl)-Pentan-1-One and Pharmaceutically Acceptable Salts Thereof