CAS: 32909-05-0; N4-Acetyl-2'-Deoxycytidine

相似化合物

110522-75-3 3768-18-1 951-77-9

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CAS号64-19-7 冰醋酸 | CAS号951-77-9 2’-脱氧胞苷 | CAS号70740-24-8 1-(4-nitro-1H-b... | CAS号108-24-7 乙酸酐 | CAS号213845-16-0 S-(1,2-Dichloro... | CAS号951-77-9 2’-脱氧胞苷 | CAS号100898-63-3 N-(1-((2R,4S,5R... | CAS号70465-61-1 N4-ETHYL-2'-DEO...

2'-脱氧胞嘧啶核苷置于吡啶,Sodium Hydroxide体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 0.33H,反应生成 N-乙酰-2'-脱氧-胞苷
参考文献:N-Acyl Protecting Groups For Deoxynucleosides
标题:N-Acyl Protecting Groups For Deoxynucleosides
摘要:
DOI:10.1016/s0040-4020(01)92022-8

专利信息

专利号:US-5726301-A
优先权日:1992-04-24
标题 :CAC H-phosphonate and its use in the synthesis of oligonucleotides
发明人：REDDY M PARAMESWARA; HANNA NAEEM B; FAROOQUI FIRDOUS
权利人:BECKMAN INSTRUMENTS INC
摘要:Disclosed herein are N4 protected deoxycytidines for use in the synthesis of oligonucleotides, the protecting groups being represented by the formula: -CO-(CH2)0-9-CH3. Preferred embodiments are N4 acetyl deoxycytidines and include N4 acetyl deoxycytidine phosphoramidites and N4 acetyl deoxycytidine H-phosphonates. When used to prepare oligonucleotides the protected deoxycytidine compounds provide high quality oligonucleotide products with little side product from cleavage and deprotection reactions carried out with alkyl amine compounds.

专利号:US-2023119227-A1
优先权日:2020-02-24
标 题:Oligonucleotide synthesis on solid support
发明人：JI AN; MARVIN MICHAEL; MARKS KEVIN; ANDERSON DAVID
权利人:INTEGRATED DNA TECH INC
摘要:Functionalized solid supports are useful in the synthesis of oligonucleotides. The functionalized solid supports contain an extended linker to a terminal functional group or a first nucleotide or nucleoside moiety. The extended linker permits oligonucleotide synthesis to take place at a greater distance from the solid support with greater efficiency.

专利号:US-5428148-A
优先权日:1992-04-24
标 题 :N4 - acylated cytidinyl compounds useful in oligonucleotide synthesis
发明人：REDDY PARAMESWARA M; HANNA NAEEM B
权利人:BECKMAN INSTRUMENTS INC
摘要:Disclosed herein are protecting groups for exocyclic amino groups of the bases adenine, guanine and cytosine for use in the synthesis of oligonucleotides, the protecting groups being represented by the formula: -CO- (CH2)0-9-CH3. In a particularly preferred embodiment, the base cytosine is protected with acetyl (-CO-CH3), and the oligonucleotide incorporating said protected cytosine is subjected to a cleavage/deprotection reagent comprising at least one straight chain alkylamine having from 1 to about 10 carbon atoms.

专利号:US-11584772-B2
优先权日:2017-09-12
标 题 :N4-modified cytidine nucleotides and their use
发明人：MESKYS ROLANDAS; JAKUBOVSKA JEVGENIJA; TAURAITE DAIVA
权利人:UNIV VILNIUS
摘要:Disclosed are W-position modified cytidine nucleotides of formula (I). Provided herein are methods of chemical synthesis of AP-modified cytidine nucleoside triphosphates and their applications as well as uses of the cytidine analogues for the synthesis of modified nucleic acids. The nucleic acid molecule includes DNA, RNA or a combination of DNA/RNA. One of many applications of modified cytidine nucleotides described herein is enzyme selection, when an enzyme of interest bears an activity of an esterase, amidase, oxidoreductase, lyase, ligase or other enzymatic activity, formula (I) wherein the substituants are as defined in the appended claims.

专利号:US-11505815-B2
优先权日:2017-11-14
标题 :Compositions and methods related to non-templated enzymatic nucleic acid synthesis
发明人：CHEN MICHAEL C; MCINROY GORDON R
权利人:NUCLERA NUCLEICS LTD
摘要:The invention relates to the use of an amine masked moiety in a method of enzymatic nucleic acid synthesis. The invention also relates to said amine masked moieties per se and a process for preparing nucleotide triphosphates comprising said amine masked moieties.

专利号:US-12030911-B2
优先权日:2018-06-15
标 题:Synthesis and biological activity of phosphoramidimidate and phosphoramidate DNA
发明人：ALAWNEH AYMAN; CARUTHERS MARVIN
权利人:UNIV COLORADO REGENTS
摘要:Oligonucleotides comprising phosphoramidimidate internucleotide linkages, and methods of efficiently synthesizing these oligonucleotides with high yield are provided. These oligonucleotides form duplexes with complementary DNA or RNA that are more stable than natural DNA or DNA/RNA complexes, are active with RNAse H1, and may be transfected into cells using standard lipid reagents. These analogues are therefore useful for numerous therapeutic antisense applications.