CAS: 52809-07-1; (S)-2-Amino-3-(3,5-Dioxo-1,2,4-Oxadiazolidin-2-yl)Propanoic Acid

上下游产品

CAS号5147-00-2 O-乙酰-L-丝氨酸 | CAS号24603-68-7 1,2,4-噁二唑啉-3,5-二酮 | CAS号52-90-4 L-半胱氨酸 | CAS号56-45-1 L-丝氨酸 | CAS号1483-07-4 L-脲基丙氨酸

在 Dowex 50W-X8(H),三氟乙酸体系中,化学反应生成 使君子氨酸
参考文献:L-半胱氨酸的合成:对映体高效合成β-氨基丙氨酸衍生物的一般方法
标题:L-半胱氨酸的合成:对映体高效合成β-氨基丙氨酸衍生物的一般方法
摘要:描述了对映体高效合成β-氨基丙氨酸衍生物的一般方法,该方法涉及通过氮杂环丁酮将氨基取代基从α羧基分子内转移到β-碳原子,并将其应用于神经兴奋性喹喹酸的高效合成.光学上纯净的状态.
DOI:10.1039/c39850000256

专利信息

专利号:US-5338851-A
优先权日:1993-03-31
标 题:Synthesis of cis-decahydroisoquinoline-3-carboxylic acids
发明人：HUFF BRET E; KHAU VIEN V; MARTINELLI MICHAEL J; PETERSON BARRY C
权利人:LILLY CO ELI
摘要:This invention provides a process for the synthesis of cis-decahydroisoquinoline-3-carboxylic acids and provides intermediates in the synthesis thereof.

专利号:US-6362009-B1
优先权日:1997-11-21
标 题 :Solid phase synthesis of heterocycles
发明人：MUNOZ BENITO; CHEN CHIXU
权利人:MERCK & CO INC
摘要:Methods for solid phase and combinatorial synthesis using a resin activation/capture approach are provided. In particular, methods for the production of dihydropyridones, N-acyidihydropyridones, tetrahydropyridones, pyridines, aminopyridines, N-acyltetrahydropyridines and tetrahydropyridines compounds and libraries containing such compounds are provided. Methods for screening the libraries and compounds and pharmaceutical compositions containing compounds prepared by the methods are provided.

专利号:US-5591867-A
优先权日:1992-12-04
标 题 :Synthesis of kainic acid
发明人：MONN JAMES A
权利人:LILLY CO ELI
摘要:This invention provides a process for preparing kainic acid and provides intermediates in the synthesis thereof.

专利号:US-5200526-A
优先权日:1987-04-27
标题:Syntheses of optically pure α-amino acids from 3-amino-2-oxetanone salts
发明人：ARNOLD LEE D; VEDERAS JOHN C
权利人:UNIV ALBERTA
摘要:A process for the preparation of optically pure α-amino acids comprising the nucleophilic ring-opening of 3-amino-2-oxetanone salts. N-Protected serine β-lactones are deprotected to form heretofore unknown 3-amino-2-oxetanone and its corresponding salts. In turn these previously unknown 3-amino-2-oxetanone salts may be used in the synthesis of other novel or rare stereochemically-pure free amino acids.

专利号:US-6448412-B1
优先权日:1995-07-31
标题:Methods for the preparation and characterization of multi-substituted fullerenes
发明人：MURPHY RANDALL B; WILSON STEPHEN R; LU QUING
权利人:SPHERE BIOSYSTEMS INC
摘要:The invention is directed to multiply-substituted fullerene derivatives of novel configurations, and methods for their preparation and use. The methods involve the combinatorial synthesis of a library of fullerene derivatives and comprises the steps of forming a mixture of fullerene derivatives by reacting the C n fullerene with two or more reactive precursor compounds, and removing the unreacted compounds to yield the fullerene derivatives having the desired activity. Methods for the identification and screening of a combinatorial library of fullerenes by 3 He-nuclear magnetic resonance and electrospray mass spectrometry to define members with the optimal desired activity are also provided.

专利号:US-6245919-B1
优先权日:1996-06-28
标 题:Cyclopropylglycine derivatives and agonists for metabotronic L-glutamate receptors
发明人：SHINOZAKI HARUHIKO; TAGUCHI TAKEO; ISHIDA MICHIKO
权利人:SHINOZAKI HARUHIKO; TAGUSHI TAKEO; NIPPON CHEMIPHAR CO
摘要:A cyclopropylglycine derivative having the following formula:and an intermediate compound for the synthesis of the cyclopropylglycine derivative are novel compounds. The cyclopropylglycine derivative shows a selectivity higher than that of the known agonists to metabotropic L-glutamate receptors, and therefore is a metabotropic type agonist to L-glutamate which has excellent characteristics.