CAS: 586-89-0; 4-Acetylbenzoic Acid

上下游产品

4-(4-methylphenyl)pentan-2-one 4-methylisopropylbenzene 4-cyanophenyl methyl ketone 4-(prop-1-en-2-yl)benzoic acid methyl 4-acetylbenzoate 4-(1-hydroxyethyl)benzoic acid 4-(2-bromoacetyl)benzoic acid 4,4'-(1,2-Dihydroxy-1,2-dimethylethylen)dibenzoesaeure

4-乙酰基苯甲酸乙酯置于水,Lithium Hydroxide体系中,用 四氢呋喃,甲醇 作为反应溶剂,化学反应 2.0H,以76%的收率获得产物4-乙酰基苯甲酸
参考文献:Novel Gpr119 Agonist Compounds
标题:Novel Gpr119 Agonist Compounds
摘要:本发明涉及公式(i)的新化合物,其制备方法以及包含这些化合物的组合物.

专利信息

专利号:US-6753449-B2
优先权日:2001-10-09
标题 :Cleavable linker for solid phase synthesis
发明人：GUO MAOJUN
权利人:ARQULE INC
摘要:Cleavable alkene-containing linkers and supports useful for the solid phase synthesis of chemical compounds, and combinatorial libraries of compounds, are disclosed. Also disclosed are methods of making and using the linkers and supports.

专利号:US-6180830-B1
优先权日:1995-11-08
标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
发明人：JACQUOT ROLAND
权利人:RHODIA CHIMIE SA
摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

专利号:US-7737287-B2
优先权日:2002-03-28
标 题 :Anomeric derivatives of monosaccharides
发明人：MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI
权利人:ALCHEMIA LTD
摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.

专利号:US-8350042-B2
优先权日:2008-01-31
标题 :Antiviral compounds for the treatment of HCV infection
发明人：HERMANN THOMAS C; CARNEVALI MAIA
权利人:UNIV CALIFORNIA; HERMANN THOMAS C; CARNEVALI MAIA
摘要:Disclosed are compounds and methods of synthesis of Formula I for the development of antiviral drugs for the treatment of HCV infection.

专利号:WO-9815532-A1
优先权日:1996-10-09
标 题:Solid phase synthesis of heterocyclic compounds
发明人：MARZINZIK ANDREAS; FELDER EDUARD
权利人:CIBA GEIGY AG; MARZINZIK ANDREAS; FELDER EDUARD
摘要:Here we report a study on a reaction sequence on solid phase, suitable for the generation of molecular diversity on small heterocycles. For each reaction, suitable conditions on solid phase were worked out and a variety of reactive agents (building blocks) was utilized in an effort to grasp the system's breadth of applicability. The inventive reaction sequence can be applied, for example, to exploit by the combinatorial approaches of the split and mix concept. The reaction sequence comprises the following steps: a) a solid carrier having reactive surface groups is loaded directly or via a spacer group with a compound bearing an aldehyde or a methylketon function, b) said function is modified using the Witting reaction or the aldol condensation, c) the heterocyclic ring is closed using a compound comprising two nucleophiles, wherein at least one of the said nucleophiles is NH2.

专利号:US-6720439-B1
优先权日:2001-09-28
标题:Synthesis of ruthenium-hydride complexes and preparation procedures of chiral alcohols and ketones
发明人：OHKUMA TAKESHI; KOIZUMI MASATOSHI; MUNIZ KILIAN; NOYORI RYOJI
权利人:INST NAGOYA IND SCIENCE RES
摘要:trans-RuH(eta<1>-BH4)[(S)-xylbinap][(S,S)-dpen] (0.00125 mmol), acetophenone (5.0 mmol), and 2-propanol (2.5 mL) were placed in an autoclave, and the resulting solution was repeatedly subject 5 times to a procedure of performing pressure reduction and argon introduction while stirring the solution for deaeration. A hydrogen tank was then connected to the autoclave, and after replacing the air inside an introduction tube with hydrogen, the pressure inside the autoclave was adjusted to 5 atmospheres and then hydrogen was released until the pressure dropped to 1 atmosphere. After repeating this procedure 10 times, the hydrogen pressure was adjusted to 8 atmospheres and stirring at 25° C. was performed for 12 hours. By concentrating the solution obtained by depressurization and subjecting the crude product to simple distillation, (R)-1-phenylethanol (yield: 95%) in the form of a colorless oily substance was obtained at an ee of 99%.