CAS: 64700-15-8; 2-((4-Methyl-2-Oxo-2H-Chromen-7-yl)Oxy)Acetic Acid

上下游产品

1-oxo-1-phenylpropan-2-yl 2-(4-methylcoumarin-7-yloxy)acetate -4-methylcoumarin7-(chlor°Carbonyl)methoxy-4-methylcoumarin methyl 2-[(4-methyl-2-oxo-2H-chromen-7-yl)oxy]acetate 2-[N-(4-methyl-2-oxobenzo[b]pyran-7-yloxyacetyl)-2-methoxyphenylaminomethylene]-2,3-dihydrobenzo[b]thiophen-3-one 2-[N-(4-methyl-2-oxobenzo[b]pyran-7-yloxyacetyl)-N-(2-p-tolylsulfonylaminophenyl)aminomethylene]-2,3-dihydrobenzo[b]thiophen-3-one

羟甲香豆素置于水,四丁基碘化铵,Potassium Carbonate,Sodium Hydroxide体系中,用 乙醇,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 36.0H,反应生成 7-(羧基甲氧基)-4-甲基香豆素
参考文献:合成和评估双功能7-羟基香豆素铂(iv)复合物作为抗肿瘤剂.
标题:合成和评估双功能7-羟基香豆素铂(iv)复合物作为抗肿瘤剂.
摘要:合成,表征和评估一系列的双功能7-羟基香豆素铂(iv)的抗肿瘤活性.7-羟基香豆素铂(iv)配合物对测试的细胞系显示中等至有效的抗肿瘤活性,在克服铂(II)药物的耐药性方面显示出很大的潜力.在还原微环境中,标题化合物可还原为铂(II)配合物,并带有两个当量的香豆素单元.7-羟基香豆素铂(iv)配合物通过释放的铂(II)化合物攻击dna,同时还抑制香豆素片段的环氧合酶活性.在抑制肿瘤增殖和克服顺铂耐药性的过程中,这种作用机制对于减少肿瘤相关的炎症可能非常有益.7-羟基香豆素的掺入导致铂在整个肿瘤细胞和dna中的积累显着增强.hsa相互作用研究表明,所测试的香豆素铂(iv)化合物可以通过范德华力和氢键与hsa有效结合.
DOI:10.1016/j.Bmc.2019.04.009

专利信息

专利号:US-5419966-A
优先权日:1991-06-10
标 题 :Solid support for synthesis of 3'-tailed oligonucleotides
发明人：REED MICHAEL W; MEYER JR RICH B; PETRIE CHARLES R; TABONE JOHN C
权利人:MICROPROBE CORP
摘要:A solid support for oligonucleotide synthesis has the structure where CPG represents a controlled pore glass matrix, the wavy line represents a carbon chain covalently linking the NH group with the controlled pore glass matrix, X is 2,2'-dimethoxytrityl or H, and R is alkyl, aryl, arylalkyl, heteroalkyl, or heteroaryl. The dimethoxytrityl group is removed from the solid support by treatment with acid, and the oligonucleotide is built, step-by-step in a conventional synthesizer after attachment of the 3' end of the first oligonucleotide unit to the hydroxyl function connected to the R group.

专利号:WO-9203464-A1
优先权日:1990-08-28
标题 :Solid support synthesis of 3'-tailed oligonucleotides via a linking molecule

专利号:DD-291759-A5
优先权日:1990-01-25
标题:PROCESS FOR SYNTHESIS OF (4,7-DIALKYL-2-OXO-2H-1-BENZOPYRAN-6-YLOXY) CARBON ACES AND ETHERS

专利号:JP-3256539-B2
优先权日:1990-08-28
标 题:Solid support synthesis of 3'-tailed oligonucleotides via linking molecules

专利号:EP-0547142-A1
优先权日:1990-08-28
标题 :Solid support synthesis of 3'-tailed oligonucleotides via a linking molecule