CAS: 74840-34-9; 4-Chloro-2-(Methylthio)Pyrimidine-5-Carboxylic Acid

相似化合物

5909-24-0 33089-15-5 148256-82-0

上下游产品

CAS号5909-24-0 4-氯-2-甲硫基嘧啶-5-羧酸乙酯

4-氯-2-甲硫基嘧啶-5-羧酸乙酯置于lithium Hydrochloride Monohydrate体系中,用 四氢呋喃,水 作为反应溶剂,以85%的收率获得产物4-氯-2-甲硫基嘧啶-5-甲酸
参考文献:C5-Substituted Pyrido[2,3-D]Pyrimidin-7-Ones As Highly Specific Kinase Inhibitors Targeting The Clinical Resistance-Related Egfrt790M Mutant
标题:C5-Substituted Pyrido[2,3-D]Pyrimidin-7-Ones As Highly Specific Kinase Inhibitors Targeting The Clinical Resistance-Related Egfrt790M Mutant
摘要:C5-取代的吡啶并[2,3-D]嘧啶-7-酮被发现为高效且特异的抑制剂,针对临床耐药相关的egfr L858R/t790M突变体.
DOI:10.1039/c5Md00208G

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:CN-109789142-A
优先权日:2016-07-01
标题 :Synthesis of N- (heteroaryl) -pyrrolo [3,2-D ] pyrimidin-2-amines