CAS: 94-52-0; 5-Nitrobenzimidazole

上下游产品

CAS号51-17-2 苯并咪唑 | CAS号99-56-9 4-硝基邻苯二胺 | CAS号122-51-0 原甲酸三乙酯 | CAS号64-18-6 甲酸 | CAS号124-38-9 二氧化碳 | CAS号3724-43-4 (氯亚甲基)二甲基氯化铵 | CAS号107-21-1 乙二醇 | CAS号57-55-6 丙二醇 | CAS号95-54-5 邻苯二胺(OPD) | CAS号107786-78-7 cyclopentyl N-[... | CAS号103248-22-2 2-chloro-N-[(6-... | CAS号103248-25-5 4-methyl-N-[(6-... | CAS号103248-24-4 1H-Benzimidazol... | CAS号103248-23-3 2-methoxy-N-[(6... | CAS号5381-79-3 (9ci)-1-甲基-6-硝基... | CAS号5381-78-2 1-甲基-5-硝基-1H -苯... | CAS号15207-93-9 1-苯甲基-5-硝基-1H-苯... | CAS号27978-94-5 N3-benzyl-5-nit... | CAS号90000-54-7 1H-苯并[d]咪唑-5,6-...

1,1-二氯甲醚 以70%的收率获得产物
参考文献:Mathias L. J.; Overberger C. G.,Synth. Commun.,1975,5,No 6,461-469
标题:Mathias L. J.; Overberger C. G.,Synth. Commun.,1975,5,No 6,461-469

专利信息

专利号:US-8669356-B2
优先权日:2009-10-21
标 题 :Linker and support for solid phase synthesis of nucleic acid
发明人：HAYAKAWA YOSHIHIRO; TSUKAMOTO MASAKI; MORI KENJIRO; MINOMI KENJIRO; MAETA ERI; KONISHI TATSUYA
权利人:HAYAKAWA YOSHIHIRO; TSUKAMOTO MASAKI; MORI KENJIRO; MINOMI KENJIRO; MAETA ERI; KONISHI TATSUYA; NITTO DENKO CORP; UNIV NAGOYA NAT UNIV CORP
摘要:The invention provides a universal linker capable of synthesizing nucleic acid having a phosphate group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker for solid phase synthesis of nucleic acid contains a compound represented by at least one of the following formulae n nwherein each symbol is as defined in the specification.

专利号:US-7807821-B1
优先权日:2004-03-01
标题 :Method for the synthesis of nucleic acid without protecting base moiety
发明人：SEKINE MITSUO; SEIO KOHJI; OHKUBO AKIHIRO
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:A phosphoramidite method for the synthesis of a nucleic acid oligomer without protecting the base moiety characterized in that a 3′ or 5′ hydroxyl group of a nucleotide is reacted with a nucleoside phosphoramidite, a cyclonucleoside phosphoramidite, a 2′-substituted nucleoside phosphoramidite, a 4′-substituted nucleoside phosphoramidite, or a 2′,4′-di-substituted nucleoside phosphoramidite to produce a phosphodiester linkage. The phosphoramidite is contacted with an activator containing both a) hydroxybenzotriazole-1-ol (HOBt), a mono-substituted HOBt, a di-substituted HOBt, or a di-substituted phenol and b) imidazole, tetrazole, benzimidazoletriflate (BIT), 4-ethylthiotetrazole, imidazolium triflate(trifluoromethane sulfonate) or 4,5-dicyanoimidazole.

专利号:WO-2024185775-A1
优先权日:2023-03-06
标 题:Long-chain alkenyloxy–substituted benzoyl derivative and oligonucleotide synthesis method using same
发明人：OKADA YOHEI; INANAGA KAZATO; SHOJI Yukiya; MIZUFUNE HIDEYA; SUDO TATSUYA; ADACHI Sota; HOSOI Kazushi
权利人:SPERA PHARMA INC; TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY
摘要:The purpose of the present invention is to provide a novel pseudo–solid phase protecting group that can be used in liquid-phase oligonucleotide synthesis. The purpose of the present invention is also to provide an oligonucleotide synthesis method that uses a novel pseudo–solid phase protecting group.　The present invention provides a compound represented by formula (1) (in which R represents a C14–60 alkenyl group, n represents 2 or 3, m represents 0 or 1, p represents 1 or 2, X represents C, N, O, or S, Y represents a single bond or B(CH 2 ) t * or may form a ring with X, and Z represents a single bond or (CH 2 ) s (s being an integer from 1 to 5)). The present invention also provides an oligonucleotide production method that uses the compound.

专利号:WO-2025082632-A1
优先权日:2023-10-16
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU
权利人:BACHEM HOLDING AG
摘要:The invention pertains to a method for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises a step of subjecting a solution comprising a component (C-0)# to one or more aqueous extractions, wherein the organic phase comprises the component (C-0)#. Said component (C-0)# is a nucleoside or an oligonucleotide, which is covalently bonded to a pseudo solid-phase protecting group and comprises a free backbone hydroxyl group. The aqueous phase of each of said one or more aqueous extractions has a pH-value in the range of 4-7.

专利号:US-8835656-B2
优先权日:2012-01-30
标 题 :Linker and support for solid phase synthesis of nucleic acid
发明人：TSUKAMOTO MASAKI; SUZUKI NORITAKA; HAYAKAWA YOSHIHIRO; MAETA ERI; MORI KENJIRO; MINOMI KENJIRO
权利人:NITTO DENKO CORP; UNIV NAGOYA NAT UNIV CORP
摘要:The invention provides a universal linker capable of synthesizing nucleic acid having a hydroxy group at the 3′ terminal, a universal support carrying the linker, and a synthesis method of nucleic acid using the universal support. The linker contains a compound represented by the formula n nwherein each symbol is as defined in the specification.

专利号:EP-4605403-A1
优先权日:2022-10-17
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.