CAS: 120801-75-4; Trimethylsilyl 2,2-Difluoro-2-(Fluorosulfonyl)Acetate

相似化合物

680-15-9 1717-59-5 757203-27-3

上下游产品

CAS号107-46-0 六甲基二硅氧烷 | CAS号677-67-8 2-(氟磺酰基)二氟乙酰基氟化物 | CAS号75-77-4 三甲基氯硅烷 | CAS号1717-59-5 2,2-二氟-2-(氟磺酰基)乙酸 | CAS号1066-40-6 三甲基硅醇 | CAS号680-15-9 氟磺酰二氟乙酸甲酯 | CAS号608-34-4 3-甲基尿嘧啶 | CAS号138101-00-5 (9CI)-(3,3-二氟-1... | CAS号260352-79-2 2,2-二氟环丙烷甲酸丁酯 | CAS号1214374-09-0 3-Chloro-2-(dif... | CAS号712-79-8 2-(二氟甲氧基)萘 | CAS号84750-92-5 3-Bromo-beta,be... | CAS号84750-93-6 4-溴-β,β-二氟苯乙烯

三甲基氯硅烷,2-氟磺酰基二氟乙酸 以78%的收率获得三甲基硅烷基 2-(氟磺酰基)二氟乙酸酯
参考文献:(2,2-二氟环丙基)甲基甲苯磺酸盐的溶剂分解反应中的反应性和区域化学行为
标题:(2,2-二氟环丙基)甲基甲苯磺酸盐的溶剂分解反应中的反应性和区域化学行为
摘要:甲苯磺酸(2,2-二氟环丙基)甲基甲苯磺酸酯和甲苯磺酸(2,2-二氟-3-甲基环丙基)甲基甲苯磺酸酯在42oc的速率常数.报告了c,并讨论了这些系统的开环反应性和区域化学性质,并与基于计算结果的预期值进行了比较.就使用(2,2-二氟环丙基)甲基系统作为机械探针进行了讨论.
Doi:10.1016/s0022-1139(02)00248-8

专利信息

专利号:US-9242998-B2
优先权日:2013-02-07
标题 :Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis C
发明人：HE SHUWEN; DAI XING; PALANI ANANDAN; NARGUND RAVI; LAI ZHONG; ZORN NICOLAS; XIAO DONG; DANG QUN; MCCOMAS CASEY C; LI PENG; PENG XUANJIA; SOLL RICHARD
权利人:HE SHUWEN; DAI XING; PALANI ANANDAN; NARGUND RAVI; LAI ZHONG; ZORN NICOLAS; XIAO DONG; DANG QUN; MCCOMAS CASEY C; LI PENG; PENG XUANJIA; SOLL RICHARD; MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-2008176865-A1
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:US-2008108694-A1
优先权日:2003-12-19
标题 :Novel Macrocycles and Uses Thereof
发明人：DANISHEFSKY SAMUEL J; YANG ZHI-QIANG; GENG XUDONG; CHOU TING-CHAO; ROSEN NEAL
权利人:DANISHEFSKY SAMUEL J; YANG ZHI-QIANG; GENG XUDONG; CHOU TING-CHAO; ROSEN NEAL
摘要:The present invention relates to compounds having the structure (and pharmaceutically acceptable derivatives thereof) n n n n n n n n n n n n wherein R o -R 4 , Z, X, A-B, D-E, G-J, and K-L are as defined herein, the synthesis thereof and the use of these compounds as therapeutic agents.

专利号:US-7968584-B2
优先权日:2005-06-15
标 题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER; PFIZER PROD INC
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:WO-2006134459-A1
优先权日:2005-06-15
标题 :Substituted arylpyrazoles
发明人：CRITCHER DOUGLAS JAMES; KYNE GRAHAM MICHAEL
权利人:PFIZER LTD; CRITCHER DOUGLAS JAMES; KYNE GRAHAM MICHAEL
摘要:This invention relates to a range of C4 substituted aryl pyrazoles of Formula (I) including those 1-arylpyrazoles in which the 4-position is substituted with an acyclic substituent, a cycloalkyl ring structure or heterocyclic ring structure and which compounds are optionally further substituted at the position a to the pyrazole ring, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.

专利号:US-7645786-B2
优先权日:2005-06-15
标题:Substituted arylpyrazoles
发明人：BILLEN DENIS; BOYLE JESSICA; CRITCHER DOUGLAS JAMES; GETHIN DAVID MORRIS; HALL KIM THOMAS; KYNE GRAHAM MICHAEL
权利人:PFIZER
摘要:This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes to their synthesis and their use as parasiticides.