CAS: 122852-42-0; Alosetron

上下游产品

4-hydroxymethyl-5-methylimidazole hydr°Chloride sodium hydrogencarbonate 2,3,4,5-tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one 4-chloromethyl-5-methyl-1-tritylimidazole

2,3,4,5-Tetrahydro-2-Tosyl-1H-Pydrido[4,3-B]Indole-1-One置于甲烷磺酸,Sodium Anthracenide,Potassium Carbonate体系中,用 N-甲基吡咯烷酮,乙二醇二甲醚,N,N-二甲基甲酰胺 用作溶剂,化学反应 24.5H,反应生成阿洛司琼
参考文献:二氧化碳对2-炔基苯胺的环状抗氮杂羧化反应
标题:二氧化碳对2-炔基苯胺的环状抗氮杂羧化反应
摘要:直接抗2-Alkynylanilines用co-Azacarboxylation 2由znet介导2中观测到,得到吲哚-3-羧酸,一类用于许多生物活性化合物的合成中的重要化合物,有效地在1大气压的co 2.不同原料的容易获得的性质以及对各种官能团的耐受性为有效构建图1中列出的生物活性化合物的多样化文库提供了巨大的机会.例如,该方法已用于合成lotronex(一种药物)用于治疗肠易激综合症的分子.
Doi:10.1021/acs.Orglett.6B00884

专利信息

专利号:US-8889897-B2
优先权日:2011-12-23
标 题:Electrocarboxylation synthesis for obtaining intermediates useful for the synthesis of SPAN derivatives
发明人：OSSO J ORIOL; VEGA LOURDES F; GALLARDO ILLUMINADO; GUIRADO GONZALO; GOMEZ ANA BELEN; RECHE FRANCISCA IRENE
权利人:AIR PROD & CHEM
摘要:The present invention relates to a process for obtaining a compound of formula (1), (2) or (3) by means of a electrocarboxylation with CO 2 . The present invention also relates to the new intermediates (1) and (2). The present invention further relates to the use of intermediates (1) and (2) as starting materials for the synthesis of SPAN derivatives.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-7807349-B2
优先权日:2002-11-29
标 题 :Protein synthesis monitoring (PSM)
发明人：SMILANSKY ZEEV
权利人:ANIMA CELL METROLOGY
摘要:A method and a device are disclosed for monitoring the synthesis of proteins by the ribosome in real time, in vivo as well as in in-vitro. The ribosome is engineered to carry a donor fluorophore, and tRNA and/or amino acids and/or some other part of the ribosome are either engineered to carry acceptor fluorophores or else their natural fluorescent properties are utilized as acceptors. As the ribosomes mechanism processed the mRNA and tRNA molecules and synthesizes a polypeptide chain, a light source illuminates the ribosome, exciting the donor fluorophores and thereby the acceptor fluorophores whenever these are in sufficient proximity to a donor. The resulting signals are detected and used as a key for real-time database searching and identification of the protein being synthesized. The resulting data can be tabulated and interpreted in different ways. FIG. ( 1 ) describes the properties of a FRET pair and the dependence of FRET on pair distance.

专利号:US-8442773-B2
优先权日:2002-11-29
标题:Protein synthesis monitoring (PSM)
发明人：SMILANSKY ZEEV
权利人:SMILANSKY ZEEV; ANIMA CELL METROLOGY
摘要:A method and a device are disclosed for monitoring the synthesis of proteins by the ribosome, wherein the ribosome is bound to a first label, for example a donor fluorophore, and a tRNA and/or amino acid are is bound to a second label, for example an acceptor fluorophore, wherein the first and second labels together from a FRET pair. As the ribosome mechanism processes the mRNA and tRNA molecules and synthesizes a polypeptide chain, a light source illuminates the ribosome, exciting the donor fluorophores and thereby the acceptor fluorophores whenever these are in sufficient proximity to a donor. The resulting signals are detected and used as a key for database searching and identification of the protein being synthesized.

专利号:US-2008280855-A1
优先权日:2005-06-22
标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles
发明人：CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH
摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:US-2013165684-A1
优先权日:2011-12-23
标题:Electrocarboxylation Synthesis for Obtaining Intermediates Useful for the Synthesis of SPAN Derivatives