CAS: 250220-36-1; (3-Phenyl-1H-Inden-1-Ylidene)Bis(Tricyclohexylphosphine)Ruthenium(Ii)Dichloride

上下游产品

tricyclohexylphosphine 1,1-diphenyl-2-propyn-1-ol carbonylchlorohydridobis(tricyclohexylphosphine)ruthenium(II)

Dichloro(3-Phenyl-1H-Inden-1-Ylidene)Bis(Triphenylphosphine)Ruthenium(II),三环己基膦 以 四氢呋喃 用作溶剂,化学反应 1.0H,以88%的收率获得双(三环己基磷)-3-苯基-1H-茚二氯化钌
参考文献:Method For Preparation Of A Ruthenium Indenylidene Complex
标题:Method For Preparation Of A Ruthenium Indenylidene Complex

专利信息

专利号:US-10384987-B2
优先权日:2014-12-16
标 题 :1,3-butadiene synthesis
发明人：DREISBACH CLAUS; SCHLENK STEFAN; HOFFMANN MARTINA; LARCHER CHRISTOPH; FOELLINGER THOMAS
权利人:ARLANXEO DEUTSCHLAND GMBH
摘要:The invention relates to a process for preparing 1,3-butadiene by means of ene-yne metathesis over at least one transition metal catalyst of the element ruthenium.

专利号:US-12202782-B2
优先权日:2020-11-19
标 题:Processes and intermediates for preparing MCL1 inhibitors
发明人：DIXON DARRYL D; ISCHAY MICHAEL A; JOHNSON TREVOR C; MERIT JEFFREY E; REGENS CHRISTOPHER S; STANDLEY ERIC A; STEINHUEBEL DIETRICH P
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.

专利号:US-9328108-B2
优先权日:2011-10-28
标 题 :Process for preparing an intermediate of the macrocyclic protease inhibitor TMC 435
发明人：HORVATH ANDRAS; WUYTS STIJN; DEPRÉ DOMINIQUE PAUL MICHEL; COUCK WOUTER LOUIS J; CUYPERS JOZEF LUDO JAN; HARUTYUNYAN SYUZANNA; BINOT GREGORY FABIEN SEBASTIAN
权利人:JANSSEN PHARMACEUTICALS INC
摘要:The present invention relates to an improved process for preparing (2R,3aR,10Z,11aS,12aR,14aR)-cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxylic acid, 2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, ethyl ester. This compound is an intermediate in the overall synthesis route of the macrocyclic compound TMC 435. TMC 435 is an inhibitor of NS3/4A protease which plays an important role in the replication of the hepatitis C virus.

专利号:US-12173015-B2
优先权日:2015-09-30
标 题:Process for producing ruthenium complexes and intermediates thereof and their use in olefin metathesis
发明人：SKOWERSKI KRZYSZTOF; GAWIN RAFAL
权利人:APEIRON SYNTHESIS SA
摘要:The invention provides a new process for producing ruthenium complexes represented by the Formula 1. Invention provides also the use of ruthenium complexes represented by the Formula 1 as precatalysts and/or catalysts in olefin metathesis reactions.

专利号:US-10017481-B2
优先权日:2012-03-17
标 题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; PIETTRE ARNAUD; GOSALBES JEAN-FRANÇOIS; THOMMEN MARC
权利人:POLYPHOR AG
摘要:The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.

专利号:US-8278322-B2
优先权日:2005-08-01
标题 :HCV NS3 protease inhibitors
发明人：HOLLOWAY M KATHARINE; LIVERTON NIGEL J; MCCAULEY JOHN A; RUDD MICHAEL T; VACCA JOSEPH P; LUDMERER STEVEN W; OLSEN DAVID B
权利人:HOLLOWAY M KATHARINE; LIVERTON NIGEL J; MCCAULEY JOHN A; RUDD MICHAEL T; VACCA JOSEPH P; LUDMERER STEVEN W; OLSEN DAVID B; MERCK SHARP & DOHME
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.