CAS: 3287-99-8; Benzylamine Hydrochloride

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CAS号100-47-0 苯甲腈 | CAS号55-21-0 苯甲酰胺 | CAS号100-46-9 苄胺 | CAS号932-90-1 苯甲醛肟 | CAS号104-54-1 肉桂醇； beta-苯丙烯醇 | CAS号103-81-1 2-苯乙酰胺 | CAS号588-46-5 N-乙酰苄胺 | CAS号17377-95-6 N-苄基对甲氧基苯胺 | CAS号85231-92-1 diethyl N-tert-... | CAS号112375-05-0 2-苄基-2-氮杂双环[2.2... | CAS号538-32-9 苄脲 | CAS号3173-56-6 异氰酸苄酯 | CAS号32018-56-7 1-苄基-4-甲基-1,2,3... | CAS号4294-16-0 N6-苄基腺苷 | CAS号1421-23-4 Imidodicarbonim... | CAS号17136-36-6 N-苄基甘氨酸 | CAS号3987-53-9 N-苄基亚胺二乙酸 | CAS号23097-87-2 1-benzyl-1,3,5-... | CAS号580-35-8 2,4,6-三苯基吡啶

苯甲醛置于ammonium Hydroxide,氢气,盐酸体系中,用 乙醚 作为反应溶剂,80.0 °C,1.0 Mpa 条件下,反应 20.0H,以92%的收率获得产物苯甲胺盐酸盐
参考文献:在非常温和的条件下使用氢气通过还原胺化共催化合成伯胺
标题:在非常温和的条件下使用氢气通过还原胺化共催化合成伯胺
摘要:在重要的化学反应中具有高活性和选择性的纳米结构和可重复使用的 3D 金属催化剂是非常需要的.在这里,开发了一种钴催化剂,用于通过还原胺化反应合成伯胺,使用氢气作为还原剂,易处理的氨水溶解在水中,作为氮源.催化剂在非常温和的条件下运行(1.5 Mol% 催化剂负载,50 oc 和 10 Bar H 2压力)并优于市售的贵金属催化剂(pd,Pt,Ru,Rh,Ir).观测到广泛的范围和非常好的官能团耐受性.高活性的关键似乎是使用的载体:一种 N 掺杂的无定形碳材料,具有小的和乱层无序的石墨域,它是微孔的,具有双峰尺寸分布,并且在孔中具有基本的 Nh 官能团.
DOI:10.1002/cssc.202100553

专利信息

专利号:US-8822702-B2
优先权日:2002-12-20
标 题 :Synthesis of amines and intermediates for the synthesis thereof
发明人：BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL
权利人:BERENS ULRICH; DOSENBACH OLIVER; SPRENGER DANIEL; BASF SE
摘要:The invention relates in a first embodiment to a method for the manufacture of esters of the formula I, n nor especially of amides of the formula II,n n nwherein the symbols have the meanings given in the specification, as well as other intermediates and compounds useful in the synthesis of tryptamines and other substances mentioned in the title. The synthesis methods and intermediates are useful in the synthesis of pharmaceuticals.

专利号:US-5225591-A
优先权日:1992-07-28
标题 :Process for making 1-cyclopentylalyl amines useful for the synthesis of sweeteners
发明人：SWEENY JAMES G; D ANGELO LIHONG L
权利人:COCA COLA CO
摘要:The disclosed process relates to a method for preparing 1-cyclopentylalkyl amines, useful in the synthesis of artificial sweeteners, by reducing an azanorbornene in a high-yield one-step reduction of an azanorbornene, wherein the method involves use of a solvent reductant system with catalyst that is compatible with the production of edible food compositions.

专利号:US-2014228554-A1
优先权日:2011-03-18
标 题:Synthesis of new fucose-containing carbohydrate derivatives
发明人：CHAMPION ELISE; DEKANY GYULA; HEDEROS MARKUS; AGOSTON KAROLY
权利人:GLYCOM AS; GLYCOM AS
摘要:A method for the synthesis of a fucooligosaccharide glycosides by reacting a fucosyl donor with H-A-R 1 or a salt thereof, wherein A and R 1 are as defined herein, under the catalysis of an enzyme capable of transferring fucose is provided. The fucooligosaccharid glycoside compounds, or derivatives thereof, their use in the manufacture of human milk oligosaccharides, and a method of manufacture of human milk oligosaccharides, are also provided.

专利号:US-7786156-B2
优先权日:2004-01-28
标 题 :Synthesis methods and intermediates for the manufacture of Rizatriptan
发明人：MARTIN PIERRE; BERENS ULRICH; BOUDIER ANDREAS; DOSENBACH OLIVER
权利人:RATIOPHARM GMBH
摘要:The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], n nor a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B]n n nwherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent.n n In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

专利号:US-2004053355-A1
优先权日:2000-05-26
标题:Modular approach to on-line synthesis, drug discovery and biochemical transformations using immobilized enzyme reactors
发明人：WAINER IRVING; MARKOGLOU NEKTARIA
摘要:A coupled system using extremely different enzymes with incompatible cofactors and reaction conditions has been constructed using standard liquid chromatographic formats and open tubular formats. One of the significant aspects of the present invention lies in the development of the liquid chromatographic on-line enzyme cascade. This has been illustrated by the biosynthetic pathway involving dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase which encompass the synthesis of the key neurotransmitters, norepinephrine and epinephrine. The results demonstrate for the first time the immobilization of dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase. The IMERs are active and can be used in a liquid chromatographic format for qualitative and quantitative determinations. The IMER-HPLC system can be used to carry out standard Michaelis-Menten enzyme kinetic studies and to quantitatively determine enzyme kinetic constants, identify specific enzyme inhibitors, provide information regarding the mode of inhibition and the inhibitor constants (K i ). A second significant aspect of the present invention lies in the ability of the immobilized enzyme reactors to be used independently or as a combination, thus providing a unique opportunity to explore the interrelationships between these enzymes, to investigate the source of diseases and to design new drug entities for identified clinical syndromes.

专利号:US-7153960-B2
优先权日:2001-12-10
标 题:Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
发明人：ZHOU JIACHENG; OH LYNETTE M; MA PHILIP; LI HUI-YIN; CONFALONE PASQUALE
权利人:BRISTOL MYERS SQUIBB CO
摘要:A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. n nThese compounds are useful as factor Xa inhibitors.