CAS: 3397-16-8; (S)-2-Stearamidopentanedioic Acid

该化合物是甲基酸的衍生物,其特点是附着一种长链脂肪酸,是一种脂酸,是一种脂酸,通常是一种白色至白色粉末,溶于有机溶剂,但水中的溶解性有限,反映了其二手性,因为含有盐酸和氢丁酸成分,因此,N-Stearoyl-L-glutamic酸经常用于制药配方,并作为一种乳化剂,因为它能够稳定油水混合物.此外,N-stearoyl-L-glutamic酸可以在药物输送系统中发挥作用,提高低溶液药物的生物利用率,其安全性一般是有利的,但与许多化学物质一样,应当按照适当的安全准则加以谨慎处理.化合物的独特结构允许它与生物膜相互作用,使其在各种生物化学应用中引起兴趣,包括在化妆品配制和作为表面活性工业工艺中的潜在用途.

结构式图片

上下游产品

N-stearoyl-L-glutamic acid dimethyl ester stearic acid L-glutamic acid Stearoyl chloride

合成工艺路线路线简述

    硬脂酸置于sodium Hydroxide体系中,用 甲醇 作为反应溶剂,化学反应生成 硬脂酰谷氨酸
    参考文献:Inter-And Intra-Molecular H-Bonds Induced Different Nanostructures From A Multi-H-Bonding (Mhb) Amphiphile: Nanofibers And Nanodiskselectronic Supplementary Information (Esi) Available: Experimental Data,Afm,Sem Images,Xrd,Ft-Ir And Cd Spectra Of Gels I And Ii,And Molecular Models. See Http://www.Rsc.Org/suppdata/cc/b4/b402956A/
    标题:Inter-And Intra-Molecular H-Bonds Induced Different Nanostructures From A Multi-H-Bonding (Mhb) Amphiphile: Nanofibers And Nanodiskselectronic Supplementary Information (Esi) Available: Experimental Data,Afm,Sem Images,Xrd,Ft-Ir And Cd Spectra Of Gels I And Ii,And Molecular Models. See Http://www.Rsc.Org/suppdata/cc/b4/b402956A/
    摘要:N-Stearoyl-L-Glutamic Acid(c18-Glu)是一种 Mhb 两性化合物,由于分子间和分子内的 H 键作用,可在亲水和疏水环境中分别形成盘状和纤维状纳米结构.
    DOI:10.1039/b402956A

    海关参考信息

    专利信息


    专利号:US-2006141078-A1
    优先权日:2004-11-10
    标题:Composition comprising a rice protein hydrolysate and an agent for increasing glycosaminoglycan synthesis
    发明人:GUILLOU VERONIQUE; THIRY ANNABELLE
    权利人:OREAL
    摘要:The present invention relates to a process for preventing and/or reducing the signs of ageing of the skin, in particular for remodelling the face and/or limiting the age-related hollowing of the face, by applying to facial skin a composition containing, in a physiologically acceptable medium, at least one rice protein hydrolysate and at least one agent for increasing glycosaminoglycan synthesis.

    专利号:US-12226379-B2
    优先权日:2022-02-08
    标 题 :Highly sustainable compositions for modulation of gene expression in human skin, and methods of production thereof
    发明人:DUGAR DEEPAK
    权利人:VISOLIS TECH INC; VISOLIS INC
    摘要:Formulations containing biologically-produced, high-purity R-mevalonolactone are provided for modulating the expression of genes and metabolism related to epidermal turnover, hyaluronic acid synthesis, barrier function, anti-aging elasticity, extracellular matrix degradation, inflammation, stress, and pigmentation in human skin. The biologically-produced, high-purity R-mevalonolactone may be used as an ingredient in pharmaceutical, food, or cosmetic products and may be applied topically or ingested for modulation of gene expression and metabolism.

    专利号:WO-2024121506-A1
    优先权日:2022-12-05
    标题:Zinc sulfide interference pigments, synthesis method and cosmetic composition
    发明人:SALEK GUILLAUME; LE BEULZE AURÉLIE; MAJIMEL JÉRÔME; GOMBART DE MATOS EMILIE; ALARD VALÉRIE
    权利人:LVMH RECH; UGIEL
    摘要:The present invention relates to interference pigments comprising a layer of a zinc sulfide material. The pigments advantageously comprise a low-refractive-index core and at least one high-refractive-index layer comprising zinc sulfide. The invention also proposes a method for synthesizing these pigments by heterogeneous precipitation of zinc sulfide on a pulverulent support, the precipitation being obtained by titration of a sodium sulfide solution at a fixed pH, during the addition of a zinc saline solution in a reaction medium containing a dispersion of the pulverulent support, at moderate temperature. The invention also relates to cosmetic compositions comprising these interference pigments which are free of titanium dioxide, wherein the titanium dioxide is generally introduced as a filler or by providing a cosmetic ingredient containing it.

    专利号:WO-2006053688-A1
    优先权日:2004-11-17
    标 题:Cosmetic and dermatological preparations for the treatment of mature skin
    发明人:DOERING THOMAS
    权利人:HENKEL KGAA; DOERING THOMAS
    摘要:The invention relates to topical cosmetic or dermatological compositions for the treatment of mature or intrinsically or extrinsically aged skin, in particular, for anti-wrinkle treatment, containing a combination of at least two selected peptides in a suitable cosmetic or dermatological vehicle, which have an effect at differing points of the process of collagen and/or fibronectin synthesis.

    专利号:WO-2006042625-A2
    优先权日:2004-10-15
    标 题 :Compositions with inhibitors of the synthesis of prostaglandin and/or of leukotriene in conjunction with stimulators of the release of cutaneous neuromediators

    专利号:EP-1799311-A2
    优先权日:2004-10-15
    标 题:Compositions with inhibitors of the synthesis of prostaglandin and/or of leukotriene in conjunction with stimulators of the release of cutaneous neuromediators
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    主要参考文献


    1: Zhu G, Yao S, Zhai H, Liu Z, Li Y, Pan H, Tang R. Evolution from Classical to Non-classical Aggregation-Based Crystal Growth of Calcite by Organic Additive Control. Langmuir. 2016 Sep 6;32(35):8999-9004. doi: 10.1021/acs.langmuir.6b01594. Epub 2016 Aug 24. doi: 10.1016/j.jcis.2013.07.020. Epub 2013 Jul 20. doi: 10.1021/ja200683t. Epub 2011 Jul 8. Epub 2004 Apr 27.

    合成参考文献


    摘要:Alimentation et la Vie., 50(77), 1962
    摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
    摘要:International Journal of Toxicology 36(Suppl. 1):17-56, 2017
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