专利号:EP-2097079-B1 优先权日:2006-11-30 标题:Modulation of prostaglandin/cyclooxygenase metabolic pathways 发明人:WUELFERT ERNST 权利人:HUNTER FLEMING LTD 摘要:A variety of diseases and disorders associated with the metabolic pathways involved in the activities of cyclooxygenase and the synthesis of prostaglandins, for example type 2 diabetes mellitus and its sequelae, ischemic vascular diseases, pain associated with inflammation, inflammatory skin conditions, spinal cord injury, peripheral neuropathy, multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis, as well as various types of cancer may be treated or prevented by the use of an agent which selectively enhances production of 15-deoxy-prostaglandin J2. The compounds are 7-hydroxy-steroids or condensed indoles.
专利号:US-6441189-B1 优先权日:2000-03-31 标 题 :Process for the preparation of matrix metalloproteinase inhibitors 发明人:BAILEY ANNE E; HILL DAVID R; HSIAO CHI-NUNG W; KURUKULASURIYA RAVI; WITTENBERGER STEVE; MCDERMOTT TODD; MCLAUGHLIN MAUREEN A 权利人:ABBOTT LAB 摘要:The instant invention provides a process for the synthesis of matrix metalloproteinase inhibitors.
专利号:WO-2008012852-A1 优先权日:2006-07-27 标 题:Intermediate compounds for the preparation of angiotensin ii antagonists 发明人:GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO 权利人:S I M S S R L SOC IT MEDICINAL; GUANDALINI LUCA; MARTINI ELISABETTA; ROMANELLI MARIA NOVELLA; DALLATOMASINA FRANCO 摘要:The present invention relates to novel substituted biphenyltetrazole compounds useful as intermediates in the preparation of angiotensin II antagonists, to a process for the synthesis of them and to a process for the conversion thereof to said molecules.
专利号:US-2016312261-A1 优先权日:2015-04-24 标 题 :Enzymatic production of cytosinic nucleoside analogues 发明人:PASCUAL GILABERT MARTA; DERONCELÉ THOMAS VICTOR M; MONTILLA ARÉVALO RAFAEL 权利人:PLASMIA BIOTECH S L 摘要:The invention relates to the enzymatic production of cytosinic nucleoside analogues. In particular it relates to a new synthesis process of cytosine nucleoside analogues by using nucleoside phosphorylase enzymes, particularly Pyrimidin Nucleoside Phosphorylases (PyNPs) or mixtures of Purine Nucleoside Phosphorylases (PNPs) and PyNPs.
专利号:EP-3070087-A1 优先权日:2011-08-05 标 题 :Intermediates for the synthesis of cyclic p1 linkers as factor xia inhibitors
专利号:US-5827855-A 优先权日:1992-12-28 标题 :Hexahydronaphthalene ester derivatives their preparation and their therapeutic uses 发明人:KOGEN HIROSHI; ISHIHARA SADAO; KOGA TEIICHIRO; KITAZAWA EIICHI; SERIZAWA NOBUFUSA; HAMANO KIYOSHI 权利人:SANKYO CO 摘要:Compounds of formula (I): (I) wherein R1 represents a group of formula (II) or (III): (II) (III) R2 is alkyl, alkenyl or alkynyl; R3 and R4 are each hydrogen, alkyl, alkenyl or alkynyl; R5 is hydrogen or a carboxy-protecting group; Ra is a group of formula -OR6; R6 is hydrogen; R6a and R6b are each hydrogen, a hydroxy-protecting group, alkyl, alkanesulfonyl, halogenated alkanesulfonyl or arysulfonyl, and their salts and esters. Such compounds inhibit the synthesis of cholesterol, and can be used for the treatment and prophylaxis of hypercholesterolemia and of various cardiac disorders.