CAS: 5119-48-2; Withaferin A

上下游产品

CAS号81345-21-3 (6R)-6-((1S)-1-... | CAS号81874-42-2 (6R)-6-((1S)-1-... | CAS号81426-86-0 (6R)-6-((1S)-1-... | CAS号85427-87-8 (3R,4aR,5aS,6aS... | CAS号81426-85-9 (6R)-6-((1S)-1-... | CAS号1214886-35-7 27-O-Acetyl-wit... | CAS号22848-79-9 Ergosta-2,24-di...

2,3-Dihydro-3β-O-Sulfate Withaferin A置于吡啶,Potassium Carbonate体系中,化学反应 1.0H,以93%的收率获得产物醉茄素 A
参考文献:2,3-二氢withaferina-3β-O-硫酸盐,是通过气生生长的withania Somnifera获得的withaferin A的新潜在前药
标题:2,3-二氢withaferina-3β-O-硫酸盐,是通过气生生长的withania Somnifera获得的withaferin A的新潜在前药
摘要:药用植物withania Somnifera(l.)dunal的根的制剂在印度的阿育吠陀医学传统中已被使用了数千年,作为缓解紧张和增强健康的一般补品,特别是在老年人中.在现代,人们已经证明,非洲醉茄具有抗血管反应生成和抗癌活性,这在很大程度上归因于甾体内酯,其中aferin A是主要成分.但是,当使用航空技术进行培养时,发现该植物会产生一种新的天然产物2,3-二氢枯草菌素a-3β-O-硫酸盐(1),它是从气生组织中提取的甲醇提取物的主要成分.1显示出的特征生物活性包括抑制癌细胞的增殖/存活,破坏细胞骨架组织和诱导细胞热休克反应,这与枯草杆菌素a(2)相似.细胞培养中1的起效延迟和1的效力降低,以及先前的观察结果表明,Withanolides中的2(3)-双键具有生物活性的要求,这表明在细胞培养基中1可能转化为2,这一点得到了证实. HPLC分析.通过气培植物获得的1的丰富产量,非常好的水溶性和
DOI:10.1016/j.Bmc.2008.10.091

专利信息

专利号:US-2025171493-A1
优先权日:2022-03-05
标题 :Processes for synthesis of withanolides and withaferins and analogs thereof
发明人：LOPCHUK JUSTIN MATTHEW
权利人:H LEE MOFFITT CANCER CT & RES
摘要:The present disclosure provides processes for the synthesis of withanolides such as Withanolide A and Withanolide D.

专利号:WO-2024105420-A3
优先权日:2022-11-15
标 题 :Cyclic designer scaffolds for the covalent targeting of proteins via michael addition
发明人：REMÉNYI ATTILA; SOÓS Tibor; PÓTI Ã?DÃ?M LEVENTE; BÃ?LINT DÃ?NIEL; ALEXA ANITA; SOK PÉTER DÃ?NIEL; TORDA LILI; VARGA SZILÃ?RD; OZSVÃ?TH KRISTÓF; ALBERT KRISZTIÃ?N; PALKÓ ROBERTA; EMBER ORSOLYA; KÃ?LLAINÉ SZARKA ESZTER; IMRE TÃ?MEA
权利人:HUN REN TERMESZETTUDOMANYI KUTATOKOEZPONT
摘要:Many biologically active natural products contain electrophilic Michael acceptor fragments. For example, curcumin and 4-hydroxyderricin contain an acyclic α,β-unsaturated ketone that alkylates cysteines. Other antitumor or anti-inflammatory herbal compounds such as Withaferin A or zerumbone contain cyclic α,β-unsaturated ketones and react with nucleophilic residues of proteins. These observations contributed to a paradigm shift in drug design and development in the last two decades: various drugs with covalent warhead have been developed and approved. Despite the apparent importance and success of covalent warheads in current drug design and developments, the applied warheads display a rather limited structural variance and complexity which automatically limits the attainable chemical space. Furthermore, to minimize possible side-reactions during the synthesis of drugs, the applied warheads are added appendages in the late-stage of the synthetic route, thus a warhead scaffold that can be synthetically easily varied using orthogonal chemistry and used as a tunable covalent warhead is still missing. Such a structurally more complex scaffold would be much more like the warheads of the natural products and is expected to be more selective in targeting nucleophiles found on the proteins. Moreover, owing to a larger contact surface, it might be more suitable for targeting shallow protein surfaces involved in protein-protein interactions.

专利号:US-2014274978-A1
优先权日:2013-03-15
标题 :Phytosterol spirostane and spirostene derivatives having a wide variety of utilities in humans and other animals
发明人：FASCIOLA ANDRE ARMEL
权利人:FASCIOLA ANDRE ARMEL
摘要:The present invention utilizes phytosterol, phytoecdysteroid, sapogenin, triterpene, terpene, spirostane, spirostene and androstene derivative compounds to provide a wide variety of utilities to humans and other animals. The compounds and methods provide numerous and wide-ranging benefits including biochemical and constructive metabolic benefits including increases in protein synthesis and synthesis efficiency, ergogenic, adaptogenic, cosmetic and medicinal skin agents and veterinary utilities. The compounds provide agents that increase physical endurance and work output, act as a general tonic for increasing health and vigor, increase sleep time and sleep efficiency and act as rejuvenating agents to reverse the effects of fatigue and stress. Novel utilities for pet, farm, zoo and companion animals are also provided.

专利号:US-12187735-B2
优先权日:2018-09-17
标 题:Matter of composition, synthesis, formulation and application of FL118 platform positions 7 and 9-derived analogues for treatment of human disease
发明人：LING XIANG; LI QINGYONG; LI FENGZHI
权利人:CANGET BIOTEKPHARMA LLC
摘要:Described herein, are the chemical synthesis, matter of compositions, formulation, function, methods and uses of the FL118 platform Positions 7 and/or 9-derived analogues for treating cancer or other human diseases. Compounds derived from chemical modifications of the FL118 platform are employed alone or in combination with other anti-cancer agents to preclude, eliminate or reverse cancer phenotypes. This invention intends to realize unique personalized cancer treatment (personalized precision medicine) through application of a series of structural relevant individual FL118 platform-derived analogues, which target multiple cellular human disease-relevant proteins and their signaling pathways.

专利号:US-2025092058-A1
优先权日:2018-09-17
标 题 :Matter of composition, synthesis, formulation and application of fl 118 platform positions 7 and 9-derived analogues for treatment of human disease
发明人：LING XIANG; LI QINGYONG; LI FENGZHI
权利人:CANGET BIOTEKPHARMA LLC
摘要:Described herein, are the chemical synthesis, compounds, methods and uses of the fluoroaryl-substituted derivatives at the FL118 position 7, which target multiple cellular human disease-relevant proteins and their signaling pathways.

专利号:WO-2011011384-A9
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates