专利号:WO-2006079916-A1 优先权日:2005-01-26 标 题 :Thieno [2,3-d] pyrimidine compounds as inhibitors of adp-mediated platelets aggregation 发明人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; RAHMAN HAYAT; SCHWEITZER BARBARA ANN; TENBRINK RUTH ELIZABETH 权利人:PHARMACIA & UPJOHN CO LLC; ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; RAHMAN HAYAT; SCHWEITZER BARBARA ANN; TENBRINK RUTH ELIZABETH 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula (I): wherein A1, A2, A3, A4, A5, A6, A7, A8, X4, X6, R2, R4, R5, and R6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:US-9217012-B2 优先权日:2009-04-08 标题 :Inhibitors of protein tyrosine phosphatases 发明人:ZHANG ZHONG-YIN; ZHANG SHENG 权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP 摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.
专利号:US-7671085-B2 优先权日:2002-11-15 标 题 :Non-steroidal farnesoid X receptor modulators and methods for the use thereof 发明人:DOWNES MICHAEL R; EVANS RONALD M 权利人:SALK INST FOR BIOLOGICAL STUDI 摘要:The efficient regulation of cholesterol synthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accordingly, the development of potent, selective, small molecule agonists, partial agonists, and antagonists of FXR would be an important step in further deconvoluting FXR physiology. In accordance with the present invention, the identification of novel potent FXR activators is described. Two derivatives of invention compounds, bearing stilbene or biaryl moieties, contain members that are the most potent FXR agonists reported to date in cell-based assays. These compounds are useful as chemical tools to further define the physiological role of FXR as well as therapeutic leads for the treatment of diseases linked to cholesterol, bile acids and their metabolism and homeostasis.
专利号:CN-102850263-B 优先权日:2012-10-10 标题 :A kind of photomagnetically controllable liquid crystal compound containing Schiff base structure in the terminal group of alkyl biphenyl and its synthesis method
专利号:CN-102850263-A 优先权日:2012-10-10 标 题 :A kind of photomagnetically controllable liquid crystal compound containing Schiff base structure in the terminal group of alkyl biphenyl and its synthesis method
参考文献:10.2116/analsci.20.717 摘要:Zhang T, Liang Y, Li B, Cui H, Gong F. Systemic analysis of structures and contents of nitrogen-containing compounds and other non-hydrocarbons in crude oils in conjunction with chemometric resolution technique. Anal Sci. 2004 Apr;20(4):717–24. doi: 10.2116/analsci.20.717.