专利号:US-8513417-B2 优先权日:2007-01-31 标题 :Method for synthesis of nitroxyl radical 发明人:UTSUMI HIDEO; SAKAI KIYOSHI; YAMADA KENICHI 权利人:UTSUMI HIDEO; SAKAI KIYOSHI; YAMADA KENICHI; UNIV KYUSHU NAT UNIV CORP 摘要:The problem to be solved by the present invention is to provide a highly-versatile method for producing a nitroxyl radical derivative, in which position-2 and position-6 in a TEMPO-based compound can be easily substituted, and further, a method for producing a nitroxyl radical derivative, in which a nitrogen nucleus is labeled with 15 N. The above-described problem can be solved by reacting a triacetoneamine derivative with ketone or aldehyde in the presence of ammonium salt or a 15 N-labeled compound thereof to obtain a 2,6-substituted-4-piperidone derivative.
专利号:WO-2025010390-A1 优先权日:2023-07-05 标题 :Synthesis of pyruvate kinase activators 发明人:FANDRICK DANIEL; LEUNG CHUN YUEN; CRANE SHELDON; LACHANCE NICOLAS; LE ROUX ANTOINE; PATEL JIGNESH; VALAMALE ASHALATHA 权利人:AGIOS PHARMACEUTICALS INC 摘要:Provided herein are methods for preparing activators of Pyruvate Kinase (PK) or a salt or a hydrate thereof.
专利号:US-2009069470-A1 优先权日:2004-11-02 标 题 :Process for the synthesis of n-alkoxyamines
专利号:US-2010076190-A1 优先权日:2007-01-31 标 题:Method for synthesis of nitroxyl radical
专利号:WO-2008093881-A1 优先权日:2007-01-31 标题:Method for synthesis of nitroxyl radical
专利号:JP-2025513294-A 优先权日:2022-04-18 标 题:Processes and intermediates for the synthesis of adagrasib
[参考文献]: Kazuhiko Sato, Et Al. A Practical Method For Epoxidation Of Terminal Olefins With 30 Hydrogen Peroxide Under Halide-Free Conditions. J Org Chem. 1996 Nov 15;61(23):8310-8311.