CAS: 60456-23-7; (S)-Oxiran-2-Ylmethanol

相似化合物

556-52-5 113826-06-5 123237-62-7

上下游产品

CAS号107-18-6 烯丙醇 | CAS号556-52-5 缩水甘油 | CAS号96-24-2 3-氯-1,2-丙二醇 | CAS号60827-45-4 |S|-(+)-3-氯-1,2-丙二醇 | CAS号2461-40-7 丁酸缩水甘油酯 | CAS号50765-70-3 (S)-1-对甲苯磺酰氧基-2... | CAS号60456-26-0 (R)-(-)-缩水甘油丁酯 | CAS号24553-03-5 phenylacetate o... | CAS号4704-77-2 3-溴-1,2-并二酚 | CAS号60456-26-0 (R)-(-)-缩水甘油丁酯 | CAS号4254-14-2 (|R|)-(-)-1,2-丙二醇 | CAS号123750-60-7 (R)-(-)-对硝基苯磺酸缩水甘油酯 | CAS号118712-60-0 (S)-(+)-对硝基苯磺酸缩水甘油酯 | CAS号66211-46-9 (R)-3-氨基-1,2-丙二醇 | CAS号70987-78-9 (S)-(+)-对甲苯磺酸缩水甘油酯 | CAS号65291-30-7 三苯甲基-(R)-缩水甘油醚 | CAS号64491-70-9 (R)-缩水甘油基甲醚 | CAS号107381-31-7 (R)-普罗帕酮 | CAS号14618-80-5 (-)-苯甲基-(R)-环氧丙基醚

3-溴-1,2-并二酚置于氢氧化钾体系中,化学反应生成 (S)-缩水甘油
参考文献:Abderhalden; Eichwald,Chemische Berichte,1915,Vol. 48,P. 1854
标题:Abderhalden; Eichwald,Chemische Berichte,1915,Vol. 48,P. 1854

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-6239313-B1
优先权日:2000-02-16
标 题 :Process for the solid state synthesis of enantiopure B-aminoalcohols from racemic epoxides
发明人：KAKULAPATI RAMA RAO; NANDURI BHANUMATHI; ELETI RAJENDER REDDY
权利人:COUNCIL SCIENT IND RES
摘要:The invention relates to a process for the solid state synthesis of enantiopure β-aminoalcohols by preparing inclusion complexes of aryloxyepoxide with cyclodextrin by adding an epoxide in equimolar ratio in an organic solvent to an aqueous solution of cyclodextrin, reacting the cyclodextrin complex of aryloxyepoxide with a nucleophile in solid state by intimately grinding the mixture using a mortar and pestle, continuing the mixing till the starting epoxide disappeared on tic, removing excess amines under vacuum, extracting the β-aminoalcohols produced with a solvent with yields of more than 50% and enantioselectivity of upto 100%.

专利号:US-5591852-A
优先权日:1990-08-10
标题 :Process for the preparation of nucleotides
发明人：VEMISHETTI PURUSHOTHAM; BRODFUEHRER PAUL R; HOWELL HENRY G; SAPINO JR CHESTER
权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING
摘要:The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.

专利号:US-2018111938-A1
优先权日:2015-05-05
标 题:Synthesis of Intermediates Used in the Manufacture of Anti-HIV Agents
发明人：PRADHAN BRAJA SUNDAR; AMARNATH KOMMIREDDY; VEMPALA NARESH; RAHMAN MD ATAUR
权利人:CBZ INVEST LTD
摘要:The present invention relates to a process of preparing intermediates of Formula (I). The process comprises of reacting compound of Formula (III) with compound of Formula (V) in the presence of a solvent selected from an alcohol, ether or water to form compound of Formula (I) wherein, R 1 is selected from —NH 2 , Cl, Br, NHCOR″, wherein R″ is alkyl, aryl, Schiff's base of formula Nâ• CHR′, wherein R′ is alkyl or aryl; R 2 is selected from H, alkyl; R 3 and R 4 , each independently is H; R 5 and R 6 , each independently is H, alkyl; R 7 is H, alkyl; and R 8 is H, alkyl.

专利号:RU-2185379-C2
优先权日:1996-01-25
标 题:Method of stereoselective synthesis of heterobicyclic alcohol enantiomer, intermediate compounds and methods of their synthesis

专利号:US-5935946-A
优先权日:1997-07-25
标 题 :Nucleotide analog composition and synthesis method
发明人：MUNGER JR JOHN D; ROHLOFF JOHN C; SCHULTZE LISA M
权利人:GILEAD SCIENCES INC
摘要:The invention provides a composition comprising bis(POC)PMPA and fumaric acid (1:1). The composition is useful as an intermediate for the preparation of antiviral compounds, or is useful for administration to patients for antiviral therapy or prophylaxis. The composition is particularly useful when administered orally. The invention also provides methods to make PMPA and intermediates in PMPA synthesis. Embodiments include lithium t-butoxide, 9-(2-hydroxypropyl) adenine and diethyl p-toluenesulfonylmethoxyphosphonate in an organic solvent such as DMF. The reaction results in diethyl PMPA preparations containing an improved by-product profile compared to diethyl PMPA made by prior methods.