CAS: 739-58-2; 4-(Diphenylphosphino)-N,N-Dimethylaniline

上下游产品

(4-dimethylamino-phenyl)-phosphonous acid dichloride N,N-dimethyl-anilineN,N-dimethyl-aniline chloro-diphenylphosphine 4-bromo-N,N-dimethylaniline [4-(dimethylamino)phenyl]diphenylphosphane oxide N,N-dimethyl-aniline4-diphenylthiophosphinoyl-N,N-dimethyl-aniline -phosphoniumbromidDiphenyl-benzyl-4-dimethylaminophenyl-phosphoniumbromid -anilinN--anilin

(4-(Dimethylamino)Phenyl)Diphenylphosphine Oxide置于草酰氯,四甲基乙二胺,Sodium Iodide体系中,用 乙腈 作为反应溶剂,以83 %的收率获得产物4-(二甲氨基)三苯基膦
参考文献:叔胺介导的氧化膦还原为膦
标题:叔胺介导的氧化膦还原为膦
摘要:在不使用高活性还原剂的情况下还原氧化膦代表了一种更安全,更可持续的有机磷化合物回收解决方案.在此,我们公开了通过不寻常的分子间氢化物转移进行的n,N,N ',N'-四甲基乙二胺(tmeda)介导的还原.机理研究表明tmeda充当氢化物供体,而p(V)卤代鏻盐充当氢化物受体.该方法提供了一种可扩展且高效的方案,可在温和条件下减少氧化膦.
DOI:10.1021/acs.Orglett.3C01690

专利信息

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:US-7884128-B2
优先权日:2005-10-13
标题:Process for total synthesis of pladienolide B and pladienolide D
发明人：KANADA REGINA MIKIE; ITO DAISUKE; SAKAI TAKASHI; ASAI NAOKI; KOTAKE YOSHIHIKO; NIIJIMA JUN
权利人:EISAI R&D MAN CO LTD
摘要:Process for producing compound of Formula: n nwherein P 2 , P 3 and R 2 are the same as defined below, characterized by comprising reacting a compound represented by Formula (7):n n nwherein P 3 means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8):n n nwherein P 2 means a protecting group for hydroxy group; and R 2 means a phenyl group which may be substituted, in the presence of a base.

专利号:US-9045520-B2
优先权日:2008-12-23
标题:Synthesis of purine nucleosides
发明人：CHUN BYOUNG-KWON; DU JINFA; RACHAKONDA SUGUNA; ROSS BRUCE; SOFIA MICHAEL JOSEPH; PAMULAPATI GANAPATI REDDY; CHANG WONSUK; ZHANG HAI-REN; NAGARATHNAM DHANPALAN
权利人:CHUN BYOUNG-KWON; DU JINFA; RACHAKONDA SUGUNA; ROSS BRUCE; SOFIA MICHAEL JOSEPH; PAMULAPATI GANAPATI REDDY; CHANG WONSUK; ZHANG HAI-REN; NAGARATHNAM DHANPALAN; GILEAD PHARMASSET LLC
摘要:A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.

专利号:WO-2023276983-A1
优先权日:2021-06-28
标题 :Synthesis intermediate for beraprost or optically active form thereof, and method for producing same
发明人：AOYAGI SHIGENOBU; YAMADA RYO
权利人:OUCHI SHINKO CHEMICAL IND CO LTD
摘要:The present disclosure provides: a novel synthesis intermediate for beraprost or an optically active form thereof; and a production method using the synthesis intermediate. More specifically, in the present disclosure, a compound represented by general formula (I) or (II) or an optically active form thereof is used as a synthesis intermediate in the production of beraprost or an optically active form thereof.

专利号:US-5600017-A
优先权日:1995-01-18
标题 :Direct hydroformylation of a multi-component synthesis gas containing carbon monoxide hydrogen ethylene and acetylene-(LAW072)
发明人：KISS GABOR; MATTURRO MICHAEL G; DECKMAN HARRY W; HORVATH ISTVAN T; DEAN ANTHONY M; HERSHKOWITZ FRANK; COOK RAYMOND A
权利人:EXXON RESEARCH ENGINEERING CO
摘要:The invention is a process for hydroformylating multicomponent syngas feed streams containing CO, H 2 , C 2 to C 5 olefins and mixtures thereof and C 2 to C 5 alkynes and mixtures thereof by contacting the multicomponent syngas feed stream with a solution of an oil soluble rhodium complex catalyst produced by complexing in solution a low valence Rh and an oil soluble triorganophoshorous compound wherein the catalyst has a P/Rh ratio of at least 30, a concentration of Rh in solution from about 1 to about 1000 ppm by weight, a total concentration of coordinatively active P of at least about 0.01 mol/l, and a ratio of [P]/p co of at least 0.1 mmol/l/kPa, wherein [P] is the total concentration of coordinatively active phosphorous in the solution, and p co is the partial pressure of CO, to produce the corresponding C 3 to C 6 aldehydes. The process has utility for the hydroformylation of streams that contain olefins and alkynes.

专利号:WO-2013065066-A1
优先权日:2011-11-02
标 题 :Processes for preparing 4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro [l,2,41-triazolo[43-a]pyrazin-7(8h)-yl]-l-(2,4,5- trifluorophenyl)butan-2-amine
发明人：PANDEY BIPIN; DAVE MAYANK GHANSHYAMBHAI; KOTHARI HIMANSHU M; SHUKLA BHAVIN SHRIPRASAD; MENDIRATTA SANJEEV KUMAR; JOSHI RUPAL; TRIVEDI UMANG
权利人:CADILA HEALTHCARE LTD; PANDEY BIPIN; DAVE MAYANK GHANSHYAMBHAI; KOTHARI HIMANSHU M; SHUKLA BHAVIN SHRIPRASAD; MENDIRATTA SANJEEV KUMAR; JOSHI RUPAL; TRIVEDI UMANG
摘要:The present invention relates to synthesis of 4-oxo-4-[3-(trifluoromethyl)-5,6- dihydro [l,2,4]-triazolo[4,3-a]pyrazin-7(8H)-yl]-l-(2,4,5-trifluorophenyl)butan-2- amine of Formula (I) either in its racemic (R/S) form or any of its optically active (S) or (R) forms or enantiomeric excess mixture of any of the forms by novel processes. The invention further relates to certain novel intermediates useful in the preparation of compound of Formula (I) and processes for their preparation.