CAS: 93777-26-5; 5-Bromo-2-Fluorobenzaldehyde

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CAS号107-31-3 甲酸甲酯 | CAS号460-00-4 对氟溴苯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号99725-12-9 2-氟-5-溴溴苄 | CAS号1015068-76-4 3-甲基-1H-吲唑-5-甲酸甲酯 | CAS号446-52-6 邻氟苯甲醛 | CAS号374538-01-9 4-氟-3-甲酰基苯硼酸 | CAS号51437-00-4 5-溴-2-氟甲苯 | CAS号53857-57-1 5-溴吲唑 | CAS号465529-57-1 1-甲基-5-溴-1H-吲唑 | CAS号465529-56-0 5-溴-2-甲基-2H-吲唑 | CAS号445303-69-5 4-溴-2-二氟甲基-1-氟苯 | CAS号202865-65-4 5-溴-2-氟苯甲醛肟 | CAS号189107-45-7 1-甲基-1H-吲唑-5-甲腈

2-氟-5-溴苄溴置于盐酸,乌洛托品,溶剂黄146体系中,用 水 作为反应溶剂,化学反应生成 5-溴-2-氟苯甲醛
参考文献:3,4-Dihydro-4-Oxo-3-(2-Propenyl)-1-Phthalazineacetic Acids And
标题:3,4-Dihydro-4-Oxo-3-(2-Propenyl)-1-Phthalazineacetic Acids And
摘要:新颖的3,4-二氢-4-氧基-3(丙-2-烯基)-1-邻苯二甲酸和式(I)的衍生物##str1##其中r.Sub.1,R.Sub.2和r.Sub.3相同或不同,代表h,卤素或线性或支链脂肪饱和或不饱和基团,该基团至少被一个卤素或r.Sub.4残基取代,R.Sub.4不为h时,除非r.Sub.4为h;r.Sub.4和r.Sub.5相同或不同,代表h,线性或支链脂肪基团,饱和或不饱和基团,芳基或杂环芳基,这些基团至少被氟,氯,溴,甲基或三氟甲基等基团取代或不取代,其中r.Sub.4和r.Sub.5不同时代表h;r.Sub.6代表羟基或烷氧基基团;r.Sub.7代表h,卤素,线性或支链脂肪饱和或不饱和基团,烷氧基基团,该基团被脂肪基或卤素基团取代或不取代,硝基基团,取代或未取代的氨基基团,S(O)Nr.Sub.8或氰基团;n等于0,1或2;r.Sub.8是线性或支链脂肪基团,芳基或杂环芳基,氨基基团,这些基团被脂肪基或卤素基团取代或不取代.本发明还涉及所述酸的可选互变异构体形式及其药学上可接受的碱盐.还描述了制备所述化合物和含有相同化合物的药物的方法.

专利信息

专利号:US-2012077802-A1
优先权日:2009-06-10
标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are spiro-cyclic compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

专利号:US-11034695-B2
优先权日:2016-09-23
标 题:Dopamine-β-hydroxylase inhibitors
发明人：SOARES DA SILVA PATRÃ?CIO; ROSSI TINO; KISS LASZLO ERNO; BELIAEV ALEXANDER; LEAL PALMA PEDRO NUNO
权利人:BIAL—PORTELA & CA S A; BIAL—PORTELA & Cᵃ S A
摘要:This invention relates to: (a) compounds of Formula Ia (with R1, R4, R5, R6, n and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-β-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds.

专利号:US-2008096883-A1
优先权日:2004-08-11
标题 :Trifluoromethyl substituted benzamides as kinase inhibitors
发明人：CARAVATTI GIORGIO; FURET PASCAL; IMBACH PATRICIA; MARTINY-BARON GEORG; PEREZ LAWRENCE BLAS; SHENG TAO
权利人:CARAVATTI GIORGIO; FURET PASCAL; IMBACH PATRICIA; MARTINY-BARON GEORG; PEREZ LAWRENCE BLAS; SHENG TAO
摘要:The invention relates to trifluoromethyl substituted benzamide compounds of the formula (I), pharmaceuticals comprising these compounds, their use as or for the manufacture of pharmaceuticals, particularly as inhibitors of protein kinases and/or the treatment of a condition, disorder or disease state mediated by a protein kinase activity and/or a proliferative disease, methods of treatment comprising administering the compounds, especially of therapeutic and prophylactic treatment, methods for the manufacture of the compounds and novel intermediates and partial steps for their synthesis.

专利号:EA-020243-B1
优先权日:2009-05-29
标题:SPYROEPOXIDES AS INTERMEDIATE PRODUCTS OF SYNTHESIS