CAS: 10160-87-9; 3,3-Diethoxyprop-1-Yne

上下游产品

Propargylic aldehyde ethanol 2,2-dibromo-propionaldehyde diethylacetal 6,6-diethoxy-3-methyl-hex-4-yn-3-ol1,3,3-triethoxypropene 4'-(pyrimidin-2-ylsulfamoyl)acetanilide 2-methylpyrimidine 1-phenylpyrazole

Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于氢氧化钾体系中,化学反应生成丙醛二乙基乙缩醛
参考文献:Sheehan; Robinson,Journal Of The American Chemical Society,1949,Vol. 71,P. 1436,1438
标题:Sheehan; Robinson,Journal Of The American Chemical Society,1949,Vol. 71,P. 1436,1438

专利信息

专利号:US-2016257688-A1
优先权日:2013-10-24
标 题 :Process for Synthesis of Lactams
发明人：TAVARES FRANCIS XAVIER
权利人:TAVARES FRANCIS XAVIER
摘要:Methods for the synthesis of lactams are presented whereby a carboxylic acid of the formula HOOC—OR—NH-LG, wherein OR is an organic moiety and LG is a leaving group, is reacted with an acid, such as an organic acid, in particular a strong acid, and a dehydrating agent, which may be one in the same such as a strong acid anhydride, such that the amount of acid added allows for the desired transformation to take place without the loss of the leaving group (LG) before the cyclization, and recovering the lactam such as that of the formula (a), provided herein, wherein G represents the atom(s) needed to form a closed ring.

专利号:US-7109377-B2
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products
发明人：SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R
权利人:HARVARD COLLEGE
摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.

专利号:WO-2024116069-A1
优先权日:2022-11-28
标题 :Novel trilaciclib intermediates, method of preparation and use thereof
发明人：KADU Rushikesh Vilasrao; RENGASAMY VADIVELANV; SINGH SATNAM; SHARMA SUBRAMANYA; DAUND VAIBHAV SURESH; KUSHWAHA SANDEEP; LAL KANHAIYA; YAZALI VENKATA SUBBARAO
权利人:ASSIA CHEM IND LTD
摘要:Aspects of the present disclosure provide novel intermediates that may be used for synthesis of Trilaciclib, pharmaceutically acceptable salts or derivatives thereof. Aspects of the present disclosure also relate to a method for preparation of Trilaciclib intermediates. Further aspects of the present disclosure relate to method for preparation of Trilaciclib, pharmaceutically acceptable salts and derivatives thereof. Still further aspects of the present disclosure are drawn towards use of the Trilaciclib intermediates for the production of Trilaciclib, pharmaceutically acceptable salts or derivatives thereof.

专利号:US-11465997-B2
优先权日:2017-06-22
标 题 :Synthesis of disorazoles and analogs thereof as potent anticancer agents
发明人：NICOLAOU KYRIACOS C; BELLAVANCE GABRIEL; BUCHMAN MAREK; PULUKURI KIRAN KUMAR; RIGOL STEPHAN
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.

专利号:US-2003082830-A1
优先权日:1996-10-16
标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products

专利号:WO-0006525-A9
优先权日:1998-07-25
标题:Synthesis of combinatorial libraries of compounds reminiscent of natural products