CAS: 19235-88-2; 4-Nitro-2-Pyridinecarbonitrile

相似化合物

13509-19-8 98139-15-2 13508-96-8

上下游产品

CAS号1124-33-0 4-硝基吡啶-N-氧化物 | CAS号77-78-1 硫酸二甲酯 | CAS号694-59-7 吡啶-N-氧化物 | CAS号29082-91-5 4-甲氧基吡啶-2-甲酸 | CAS号13509-19-8 4-硝基-2-吡啶甲酸

4-硝基吡啶-N-氧化物 以 水 用作溶剂,化学反应 2.0H,反应生成2-氰基-4-硝基吡啶
参考文献:单组分no螯合的芳基镍(II)络合物作为乙烯聚合和co /乙烯共聚催化剂.配体引起的反应途径变化的例子
标题:单组分no螯合的芳基镍(II)络合物作为乙烯聚合和co /乙烯共聚催化剂.配体引起的反应途径变化的例子
摘要:[nir(no)l] [no = 4-硝基吡啶-2-羧酸(4-No 2-Pyca)类型,R =邻甲苯基,L = Pph 3;No = 2-吡嗪羧酸酯(pyzca),R =邻甲苯基,L = Pph 3 ; 制备并表征了no = 4-甲氧基吡啶-2-羧酸酯(4-Meo-Pyca),R =邻甲苯基,L = Pph 3 ].配合物[ni(邻甲苯基)(pyca)pph 3 ],1和同构类似物[ni(邻甲苯基)(4-No 2-Pyca)pph 3 ],3的单晶x射线研究,显示有关镍中心预期正方平面配位,与吡啶氮是反式,为两种化合物的膦配体.两种络合物的配位域非常相似,对于包含4-No 2-Pyca配体的络合物3,Ni-N键没有伸长.在复杂的3所述ø甲苯基配体是无序在两个位点指示的存在下,在固体状态中,两个构象异构体,其中ò的甲基团ö-Tolyl位于协调平面的任一侧.具有取代的pyca配体的配合物
Doi:10.1016/s0022-328X(96)06953-7

专利信息

专利号:EP-1875239-B1
优先权日:2005-04-27
标题 :A method for the preparation of imaging probes using click chemistry
发明人：KOLB HARTMUTH C; MOCHARLA VANI P; WALSH JOSEPH C
权利人:SIEMENS MEDICAL SOLUTIONS
摘要:The invention provides a method for identifying a candidate imaging probe, the method comprising: a) contacting a first library of candidate compounds with a target biomacromolecule, b) identifying a first member from the first library exhibiting affinity for the first binding site; c) contacting the first member identified from the first library affinity for the first binding site with the target biomacromolecule; d) contacting a second library of candidate compounds with the first member and the target biomacromolecule, e) reacting the complementary first functional group with the second functional group via a biomacromolecule induced click chemistry reaction to form the candidate imaging probe; f) isolating and identifying the candidate imaging probe; g) preparing the candidate imaging probe by chemical synthesis; and h) for imaging applications, converting the candidate imaging probe into an imaging probe.