CAS: 20357-24-8; 5-Methoxy-2-Nitrobenzaldehyde

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CAS号42454-06-8 5-羟基-2-硝基苯甲醛 | CAS号74-88-4 碘甲烷 | CAS号879-55-0 (5-甲氧基-2-硝基苯基)甲醇 | CAS号77-78-1 硫酸二甲酯 | CAS号96042-30-7 2-[2-[(E)-2-[4-... | CAS号1882-69-5 5-甲氧基-2-硝基苯甲酸 | CAS号591-31-1 3-甲氧基苯甲醛 | CAS号63932-00-3 5-methoxy-2-nit... | CAS号100-83-4 间羟基苯甲醛 | CAS号39755-95-8 5-甲氧基靛红 | CAS号38469-84-0 2-硝基-5-甲氧基苯腈 | CAS号26831-52-7 Benzaldehyde,2-... | CAS号850424-11-2 2-氯-6-甲氧基喹唑啉 | CAS号1882-69-5 5-甲氧基-2-硝基苯甲酸 | CAS号86210-92-6 6-甲氧基-2-甲基喹啉-3-羧酸乙酯 | CAS号59292-36-3 5-甲氧基-3-吲哚甲酸乙酯 | CAS号54197-64-7 6-甲氧基-3,4-二氢-2(... | CAS号7507-86-0 2-溴-5-甲氧基苯甲醛

5-甲氧基-2-硝基苯甲酸置于dimethyl Sulfide Borane,2-碘酰基苯甲酸体系中,用 四氢呋喃,二甲基亚砜 用作溶剂,化学反应 16.0H,反应生成5-甲氧基-2-硝基苯甲醛
参考文献:水镁化作用下的铁催化还原环化:一种针对 N-杂环的模块化策略
标题:水镁化作用下的铁催化还原环化:一种针对 N-杂环的模块化策略
摘要:通过使用邻位还原环化制备各种n-杂环-乙烯基苯胺,据报道.该反应由廉价且稳定的铁络合物催化,通常在环境温度下发生.转化可能是通过乙烯基的水镁化作用进行的,并通过分子内亲电试剂捕获原位生成的苄基阴离子以形成杂环.这种铁催化的策略被证明具有广泛的适用性,并被用于合成取代的吲哚,羟吲哚和四氢苯并氮杂吲哚酮衍生物.机理研究表明,氢化物转移步骤的可逆性取决于束缚的亲电试剂的反应性.通过正式合成已报道的生物活性化合物和一系列天然产物,进一步证明了我们方法的合成效用.
Doi:10.1002/anie.202106996

专利信息

专利号:US-6683205-B2
优先权日:2001-02-15
标 题 :Synthesis of 2-aryl propenoic acid esters for the production of non-steroidal anti-inflammatory drugs
发明人：HOSSAIN M MAHMUN
权利人:WISYS TECHNOLOGY FOUND INC
摘要:A method of producing a compound of the formula: n and its pharmaceutically acceptable salts, wherein Ar is a substituted or unsubstituted aromatic or heteroaromatic group; comprising: n (1) reacting a compound of the formula: n wherein Ar is as described above, with N 2 CHCOOR, wherein R is alkyl, in the presence of a catalytic amount of a Bronsted acid or Lewis acid to form a compound of the formula: n wherein Ar and R are as described above; and n (2) reacting the compound of formula (II) with a reducing agent in the presence of an alkyl amine to form a compound of the formula: n wherein Ar and R are as described above.

专利号:US-2002120153-A1
优先权日:2001-02-15
标题 :Synthesis of 2-aryl propenoic acid esters for the production of non-steroidal anti-inflammatory drugs