1,7-辛二烯置于氧气,三异丁基铝,三溴化磷体系中,用 苯 用作溶剂,化学反应 15.0H,反应生成8-溴-1-辛烯 参考文献:Pheromones Of Insects And Their Analogs. V. A New Approach To The Synthesis Of The Sex Pheromones Of Insects Of The Orderlepidoptera Which Is Based On The Selective Ozonolysis Of 1-Methylcycloocta-1Z,5Z-Diene 标题:Pheromones Of Insects And Their Analogs. V. A New Approach To The Synthesis Of The Sex Pheromones Of Insects Of The Orderlepidoptera Which Is Based On The Selective Ozonolysis Of 1-Methylcycloocta-1Z,5Z-Diene 摘要: Doi:10.1007/bf00577199
专利号:WO-2009152051-A1 优先权日:2008-06-12 标题:Synthesis of a macrocyclic hcv protease inhibitor 发明人:WANG PENG 权利人:PHENOMIX CORP; WANG PENG 摘要:The present invention provides a method of synthesis of a macrocyclic compound known as a potent inhibitor of a protease produced by the hepatitis C virus (HCV). Inhibition of the viral protease blocks assembly of mature viral particles in an infected mammalian host. The method of synthesis involves a ring-closing metathesis step using a ruthenium catalyst. Hydrogenation and boronate deprotection provide the HCV protease-inhibitory product.
专利号:US-6946533-B2 优先权日:2002-08-01 标 题 :Synthesis of macrocyclic polymers by ring insertion polymerization of cyclic olefin monomers 发明人:GRUBBS ROBERT; BIELAWSKI CHRIS; BENITEZ DIEGO 权利人:CALIFORNIA INST OF TECHN 摘要:A method for synthesizing cyclic polymers using transition metal alkylidene complexes as reaction catalysts is provided, wherein the complexes contain a cyclic group. Polymerization is carried out on the catalyst, using cyclic olefin monomers that undergo ring insertion polymerization, and no linear intermediates are generated. Following completion of polymerization, the cyclic polymer detaches from the complex via an intramolecular chain transfer reaction and the catalytic complex is regenerated. The invention also provides novel transition metal alkylidene complexes useful as catalysts in the aforementioned process, as well as novel cyclic hydrocarbons.
专利号:US-5319113-A 优先权日:1992-08-28 标题 :Preparation of liquid crystalline di(alkoxyglycidyl) compounds, and their use in curable epoxide mixtures 发明人:MALLON JOSEPH J; ADAMS PAUL M 权利人:AEROSPACE CORP 摘要:The invention relates to new, liquid crystalline di(alkoxyglycidyl) compounds of optionally ring substituted 1,4-dibenzoyloxybenzenes in which an alkoxy group consisting of 2 to 8 carbon atoms is incorporated between the glycidyl groups and the 1,4-dibenzoyloxybenzene, a synthesis of 4,4'-di(hexoxyglycidyl)-(1,4-dibenzoyloxybenzene), furthermore epoxy resin mixtures containing the new dialkoxyglycidyl compounds and the epoxy resin mixtures thereof in curable mixtures.
专利号:EP-1636294-B1 优先权日:2003-06-20 标 题 :Synthesis method for a compound used to form a self-assembled monolayer, compound for forming a self-assembled monolayer, and layer structure for a semiconductor component 发明人:EFFENBERGER FRANZ; SCHUETZ MARKUS; MAISCH STEFFEN; SEIFRITZ STEFFEN; SCHMID GUENTER; HALIK MARCUS; KLAUK HAGEN; ZSCHIESCHANG UTE; HOLBERG STEFAN 权利人:QIMONDA AG 摘要:The invention relates to a synthesis method for a compound used to form a self-assembled monolayer, especially a monolayer for a semiconductor component, said method being characterised in that: a) it comprises a first synthesis step wherein a terminal nucleophile substitution of the halogen with a group able to perform a Î -Î interaction, especially a group having at least one aromatic group (Ar), is carried out on a ?-halogen-alk-1-ene (I), and b) the product of the first synthesis step is hydrolysed in a second synthesis step. The invention also relates to compounds for forming a self-assembled monolayer, and a layer structure. The inventive synthesis method thus enables compounds to be efficiently produced, generating a high yield and simple cleaning requirements.
专利号:US-2010298504-A1 优先权日:2007-09-19 标题 :Amphiphilic polymer and processes of forming the same 发明人:Janczewski Dominik; TOMCZAK NIKODEM; KHIN YIN WIN; HAN MINGYONG; VANCSO JULIUS 权利人:AGENCY SCIENCE TECH & RES 摘要:Disclosed are an amphiphilic polymer, its synthesis and uses thereof. The polymer has a hydrocarbon backbone with —COOH side groups. It further has first aliphatic moieties with a main chain of about 3 to about 20 carbon atoms and 0 to about 3 heteroatoms, and second aliphatic moieties that have a main chain of about 3 to about 80 carbon atoms and about 2 to about 40 heteroatoms. The second aliphatic moieties have a copolymerisable group. In the synthesis a maleic anhydride polymer of formula (I) where n is an integer from about 10 to about 10000 and R1 is H or methyl, is reacted with a monofunctional compound with an alkyl chain of about 3 to about 20 carbon atoms and 0 to about 2 heteroatoms, and with an at least bifunctional compound with an alkyl chain of about 3 to about 80 carbon atoms and 0 to about 40 heteroatoms. The functional group of the monofunctional compound and one functional group of the at least bifunctional compound can form a linkage with an anhydride. Another functional group of the at least bifunctional compound, which is not allowed to react with the maleic anhydride polymer, is copolymerisable.
专利号:US-2004132934-A1 优先权日:2002-08-01 标题 :Synthesis of macrocyclic polymers by ring insertion polymerization of cyclic olefin monomers
[参考文献]: Carolyn A Leverett, Et Al. Application Of The Aza-Achmatowicz Oxidative Rearrangement For The Stereoselective Synthesis Of The Cassia And Prosopis Alkaloid Family. J Org Chem. 2006 Oct 27;71(22):8591-601. [参考文献]: Christophe Dubost, Et Al. A Concise Total Synthesis Of The Lichen Macrolide (+)-Aspicilin. Org Lett. 2006 Oct 26;8(22):5137-40.
合成参考文献
摘要:Bartels, F.; Zimmer, R.; Christmann, M., Science of Synthesis Knowledge Updates, (2017) 3, 271. 摘要:Liu, G.; Chen, P., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 31. 摘要:Ouyang, Y.; Shou, J.-Y.; Qing, F.-L., Science of Synthesis: Special Topics, (2022) 1, 309. 摘要:Ouyang, Y.; Shou, J.-Y.; Qing, F.-L., Science of Synthesis: Special Topics, (2022) 1, 296. 摘要:Wu, S.; Song, H.; Hu, M., Science of Synthesis: Modern Strategies in Organofluorine Chemistry , (2024) 1, 76.