CAS: 36357-38-7; 5-Acetyl-2-Methylpyridine

该化合物是有机化合物,其特点是具有螺旋环结构,有助于其芳香特性.该化合物具有一个可喜功能组,特别是乙酮杂音,附于一个在6点有甲基组的环上.该甲基组的存在增强了其脂性,有可能影响其在有机溶剂中的溶解性.分子结构表明它可能展示生物活动,引起对药用化学和药剂学的兴趣.其物理特性,如沸点,熔点和溶性,可能因环境条件和其他物质的存在而不同.此外,该化合物的再活性可能涉及典型的氯酮反应,如核素添加和氧化.

结构式图片

相似化合物

100189-16-0 249583-84-4 221615-71-0

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

acetylacetaldehyde dimethyl acetal 1-amino-1-buten-3-one (E)-4-chloro-3-buten-2-one ethyl 3-(2-methyl-5-pyridinyl)-3-oxopropanoate 1-(6-methyl-[3]pyridyl)-1-phenyl-ethanol 5-(1-hydroxyethyl)-2-methylpyridine 6-methylnicotinic acid 2-(6-methylpyridin-3-yl) ethan-1-ol

合成工艺路线路线简述

    5-乙基-2-甲基-吡啶置于chromium(Vi) Oxide,硫酸,乙酸酐,Sodium Carbonate体系中,用 溶剂黄146,水 作为反应溶剂,化学反应 24.0H,反应生成 5-乙酰基-2-甲基吡啶
    参考文献: Pyridazin-3 (2H)-One Derivatives And Their Use As Pde4 Inhibitors[fr] Derives De Pyridazine-3(2H)-Ones Et Utilisation En Tant Qu'Inhibiteurs De Pde4
    标题: Pyridazin-3 (2H)-One Derivatives And Their Use As Pde4 Inhibitors[fr] Derives De Pyridazine-3(2H)-Ones Et Utilisation En Tant Qu'Inhibiteurs De Pde4
    摘要:新吡啶唑-E-(2H)-酮衍生物,具有通用公式(I)的化学结构被公开;以及它们的制备过程,包含它们的药物组合物以及它们作为磷酸二酯酶4抑制剂的疗法使用.

    海关参考信息

    专利信息


    专利号:US-8703952-B2
    优先权日:2008-12-12
    标题:Synthesis of 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline and analogues and intermediates
    发明人:WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID
    权利人:WILLIAMSON CRAIG; STOREY JOHN MERVYN DAVID; WISTA LAB LTD
    摘要:The present invention pertains generally to methods of preparing certain 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds and their analogues, and especially to methods of preparing dimebon. The present invention also pertains to methods of preparing certain intermediate compounds which find use in the synthesis of the 9-(arylalkyl)-1,2,3,4-tetrahydro-γ-carboline compounds.

    专利号:US-8664402-B2
    优先权日:2011-03-09
    标题:Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib
    发明人:CASTELLIN ANDREA; STABILE PAOLO; FONTANA FRANCESCO; DE LUCCHI OTTORINO; CAPORALE ANDREA; TARTAGGIA STEFANO
    权利人:CASTELLIN ANDREA; STABILE PAOLO; FONTANA FRANCESCO; DE LUCCHI OTTORINO; CAPORALE ANDREA; TARTAGGIA STEFANO; ITALIANA SINT SPA
    摘要:A process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methyl sulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. The synthesis of the intermediates useful for such preparation is also described.

    专利号:US-8501941-B2
    优先权日:2005-02-25
    标题 :Methods for the synthesis of unsymmetrical cycloakyl substituted xanthines
    发明人:WANG GUOQUAN; RIEGER JAYSON M; THOMPSON ROBERT D
    权利人:WANG GUOQUAN; RIEGER JAYSON M; THOMPSON ROBERT D; DOGWOOD PHARMACEUTICALS INC
    摘要:The present invention provides compounds and pharmaceutical compositions that are selective antagonists of A 2B adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents. Also provided are processes for the preparation of the compounds and their intermediates.

    专利号:US-8765962-B1
    优先权日:2013-01-22
    标题:Very efficient process for preparing an intermediate of etoricoxib
    发明人:STABILE PAOLO; GALVAGNI MARCO
    权利人:F I S —FABBRICA ITALIANA SINT S P A; F I S —FABRICA ITALIANA SINT S P A
    摘要:The present invention relates to an efficient process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. Water is employed as reaction medium.

    专利号:US-10906888-B2
    优先权日:2016-07-14
    标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
    发明人:CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
    权利人:PFIZER
    摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-2007105821-A1
    优先权日:2005-02-25
    标 题 :Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines
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    合成参考文献


    摘要:Elie, M.; Renaud, J.-L.; Gaillard, S., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 205.
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